2014
DOI: 10.1681/asn.2013070786
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Genetic Susceptibility and Loss of Nr4a1 Enhances Macrophage-Mediated Renal Injury in CKD

Abstract: Nuclear hormone receptors of the NR4A subgroup have been implicated in cancer, atherosclerosis, and metabolic disease. However, little is known about the role of these receptors in kidney health or disease. Nr4a1-deficient rats (Nr4a1 The incidence of CKD has increased over the last 2 decades. 1 Current estimates suggest that approximately 10% of adults in the United States have CKD. 2 Considering only federal Medicare spending, the direct economic effect of CKD is staggering. The cost to treat CKD (predialysi… Show more

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Cited by 37 publications
(35 citation statements)
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“…57,58 At 10 months, MAP was measured by indwelling catheter, and animals were euthanized for collection of serum, organ weights, and histologic analysis. 57,58 Careful animal dissections were performed to investigate the nature and type of other urogenital abnormalities that occurred along with unilateral renal agenesis. Animals from three generations (n=487 animals) were analyzed to determine the frequency of unilateral renal agenesis in both female and male animals.…”
Section: Protocol 1: Kidney-specific Phenotypes and Other Urogenital mentioning
confidence: 99%
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“…57,58 At 10 months, MAP was measured by indwelling catheter, and animals were euthanized for collection of serum, organ weights, and histologic analysis. 57,58 Careful animal dissections were performed to investigate the nature and type of other urogenital abnormalities that occurred along with unilateral renal agenesis. Animals from three generations (n=487 animals) were analyzed to determine the frequency of unilateral renal agenesis in both female and male animals.…”
Section: Protocol 1: Kidney-specific Phenotypes and Other Urogenital mentioning
confidence: 99%
“…At month 5, MAP and RBF were measured as previously described. 57,58 Protocol 5: Temporal Study of Renal Injury in HSRA-S, HSRA-C, and Uninephrectomized HSRA-C Rats Four groups of male animals were established to study the time course development of proteinuria: (1) HSRA-S, (2) HSRA-C, (3) HSRA-UNX3 (uninephrectomized at 3 weeks of age), and (4) HSRA-UNX8 (uninephrectomized at 8 weeks of age). Uninephrectomy was performed using two-kidney (HSRA-C) animals, and sham operations were performed on littermate HSRA-S animals.…”
Section: Protocol 3: Micro-ct Of Kidney Vasculaturementioning
confidence: 99%
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