Genetic Susceptibility to Cancer

Dong, Linda M.; Potter, John D.; White, Emily; Ulrich, Cornelia M.; Cardon, Lon R.; Peters, Ulrike

doi:10.1001/jama.299.20.2423

Cited by 366 publications

(103 citation statements)

References 126 publications

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“…In addition to the well-defined, highly penetrant modifications to genes such as BRCA1 and BRCA2, which are only observed in a limited number of cases, certain common, low-penetrance variations have been identified in other genes potentially implicated in BC (Dong et al, 2008). Recently, several genome-wide association studies (GWAS; Antoniou et al, 2008;Garcia-Closas et al, 2008;Mcinerney et al, 2009;Latif et al, 2010) have revealed multiple BC-associated loci, of which the majority are single nucleotide polymorphisms (SNPs).…”

Section: Introductionmentioning

confidence: 99%

Increased risk of breast cancer in individuals carrying the TNRC9 rs3803662 C>T polymorphism: a meta-analysis of case-control studies

Wang

Cao

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Currently, the relationship between the trinucleotide repeat containing 9 (TNRC9) rs3803662 C>T polymorphism and risk of breast cancer (BC) is uncertain. Here, we attempted to obtain a more accurate assessment of this association by conducting a meta-analysis of all eligible case-control investigations, comprising 44,820 cases and 58,316 controls. A comprehensive search was performed to identify all suitable studies involving the TNRC9 rs3803662 polymorphism and BC risk. Pooled odds ratios (ORs) and 95% confidence intervals (95%CIs) were estimated using fixed-or random-effect models. Heterogeneity, publication bias, and sensitivity analyses were also carried out. We found that the variant T allele of rs3803662 C>T greatly increases BC risk (CT vs CC: OR = 1.14, 95%CI = 1.07-1.22, P < 0.001; TT vs CC: OR = 1.38, 95%CI = 1.25-1.53, P < 0.001; CT/TT vs CC: OR = 1.19, 95%CI = 1.11-1.28, P < 0.001; TT vs CT/CC: OR = 1.28, 95%CI = 1.19-1.38, P < 0.001). Stratified analysis based on ethnicity also revealed a markedly increased risk in Asian and Caucasian populations. Moreover, studies with hospital-based control groups showed elevated risk under the four genetic models employed, as did those using population-based controls, except under heterozygote comparison. The TNRC9 rs3803662 C>T polymorphism is greatly related to increased risk of BC, in both Asian and Caucasian populations.

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Section: Introductionmentioning

confidence: 99%

Increased risk of breast cancer in individuals carrying the TNRC9 rs3803662 C>T polymorphism: a meta-analysis of case-control studies

Wang

Cao

et al. 2016

Genet. Mol. Res.

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“…Previous studies reported that the IL-17 gene is expressed by Th17 cells and modifies chronic inflammation, and SNPs in IL-17 may alter gene expression, thus changing protein function and contributing to cancer risk (Park et al, 2005;Dong et al, 2008). Here, we performed a hospital-based case-control study to assess whether the IL-17 rs2275913 genetic variation could influence susceptibility to gastric cancer, and we found that IL-17 rs2275913 genetic variations appear to be associated with an elevated risk of gastric cancer in a Chinese population.…”

Section: Discussionmentioning

confidence: 99%

IL-17 rs2275913 genetic variation contributes to the development of gastric cancer in a Chinese population

Dong

et al. 2016

Genet. Mol. Res.

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ABSTRACT. The purpose of this hospital-based case-control study was to assess whether the interleukin (IL)-17 rs2275913 genetic variation can influence susceptibility to gastric cancer. Samples from a total of 202 gastric cancer patients and 237 controls were collected from the Linyi People's Hospital between March 2013 and March 2015. The IL-17 rs2275913 gene polymorphism was identified by polymerase chain reaction and restriction fragment length polymorphism. When compared with control subjects, gastric cancer patients were older in age (OR = 3.89, 95%CI = 2.55-5.95), male (OR = 2.08, 95%CI = 1.39-3.10), had a habit of alcohol consumption (OR = 1.71, 95%CI = 1.15-2.55), and were more likely to be infected with Helicobacter pylori (OR = 2.76, 95%CI = 1.83-4.16). We observed that the AA genotype of the IL-17 rs2275913 polymorphism resulted in a 2.32-fold risk of gastric cancer compared to the GG genotype (OR = 2.32, 95%CI = 1.20-4.54; P = 0.01). The AG combined with AA genotype of the IL-17 rs2275913 polymorphism had more risk of developing gastric cancer than the GG genotype (OR = 1.50, 95%CI = 1.01-2.23; P = 0.04). Moreover, the AA genotype of the IL-17 rs2275913 polymorphism was correlated with a higher risk of developing gastric cancer than the GG and AG genotypes combined (OR = 2.01, 95%CI = 1.08-3.79; P = 0.02). In conclusion, the results of our study suggest that the IL-17 rs2275913 polymorphism could contribute to the risk of gastric cancer.

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“…Wacholder et al (2004) suggested that the statistical power be estimated based on the ability to detect an OR of 1.5, when the alpha level was equal to the observed P value. Dong et al (2008) found that for small ORs, an OR of 1.5 could be too conservative; so both ORs of 1.5 and 1.2 were used. FPRP values less than 0.2 indicate that the association is still significant for a given level of prior probability.…”

Section: Methodsmentioning

confidence: 99%

Role and diagnostic value of gene variants in assessing the risk of chronic obstructive pulmonary disease

et al. 2016

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ABSTRACT. Meta-analyses have revealed many positive associations between gene variants and susceptibility to chronic obstructive pulmonary disease (COPD). However, some of those positive results may be false positives. Therefore, we investigated the genetic polymorphisms associated with COPD risk and determined their diagnostic value. We extracted the odds ratio (OR) and 95% confidence interval for each polymorphism from published meta-analyses concerning gene variants and COPD susceptibility in October 2014, subsequently we calculated false-positive report probabilities (FPRPs) for statistically significant associations (P value < 0.05). We determined the diagnostic value of the true positive polymorphisms of COPD using the Meta-DiSc software. Twenty-five gene polymorphisms were significantly associated with COPD risk. The FPRP test results were as follows: 1) when the prior probability was 0.001 and the OR was 1.5, ADAM33 rs612709, CHRNA3/5 rs1051730, CHRNA3/5 rs8034191, CHRNA3/5 rs16969968, and TGFB1 rs1800470 were truly associated with COPD risk (FPRP < 0.2); 2) when the prior probability was 0.000001 and the OR was 1.5, all the variants except TGFB1 rs1800470 remained noteworthy; and 3) when the probability was 0.000001 and the OR was 1.2, ADAM33 rs612709 and CHRNA3/5 rs1051730 remained true positives. Unfortunately, the results of the diagnostic accuracy meta-analyses suggested that none of the variants had high value for COPD diagnosis.

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Genetic Susceptibility to Cancer

Cited by 366 publications

References 126 publications

Increased risk of breast cancer in individuals carrying the TNRC9 rs3803662 C>T polymorphism: a meta-analysis of case-control studies

Increased risk of breast cancer in individuals carrying the TNRC9 rs3803662 C>T polymorphism: a meta-analysis of case-control studies

IL-17 rs2275913 genetic variation contributes to the development of gastric cancer in a Chinese population

Role and diagnostic value of gene variants in assessing the risk of chronic obstructive pulmonary disease

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