Genetic variants in the tryptophan hydroxylase 2 gene (TPH2) and depression during and after pregnancy

Fasching, Peter A.; Faschingbauer, Florian; Goecke, Tamme W.; Engel, Anne; Häberle, Lothar; Seifert, Anna; Voigt, F; Amann, Manuela; Rebhan, Dirk; Burger, Peter; Kornhuber, Johannes; Ekici, Arif B.; Beckmann, Matthias W.; Binder, Elisabeth B.

doi:10.1016/j.jpsychires.2012.05.011

Cited by 47 publications

(17 citation statements)

References 71 publications

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“…We observed differences regarding the influence of genetic factors according to the time of onset of depressive symptoms. These findings were replicated in studies using both population (Forty et al, 2006;Murphy-Eberenz et al, 2006) and molecular approaches (Binder et al, 2010;Comasco et al, 2011a;Comasco et al, 2011b;Doornbos et al, 2009;Fasching et al, 2012;Lewis et al, 2012;Pinsonneault et al, 2013;Xie and Innis, 2009). Furthermore, we found that the influence of genetic factors became more consistent when methodological variations among studies were considered, such as the assessment period, interactions with environmental factors, and the tools used to detect depressive symptoms.…”

Section: Discussionsupporting

confidence: 81%

The Influence of genetic factors on peripartum depression: A systematic review

Figueiredo

Parada

Araújo

et al. 2015

Journal of Affective Disorders

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Section: Discussionsupporting

confidence: 81%

The Influence of genetic factors on peripartum depression: A systematic review

Figueiredo

Parada

Araújo

et al. 2015

Journal of Affective Disorders

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“…One of these studies (Fasching et al 2012) documented in 361 women that a haplotype block in the promoter region of the tryptophan hydroxylase type 2 isoform, but not a haplotype block in intron 8, was associated with PPD symptoms at 6 to 8 months post partum but not immediately after birth. In contrast, the absence of a link for the tryptophan hydroxylase type 1 (Khabour et al 2013) and type 2 (Khabour et al 2013, Pinsonneault et al 2013) isoforms was reported in studies with similar sample sizes.…”

Section: Biological Predictors Of Postpartum Depressionmentioning

confidence: 99%

Biological and Psychosocial Predictors of Postpartum Depression: Systematic Review and Call for Integration

Yim

Stapleton

Guardino

et al. 2015

Annu. Rev. Clin. Psychol.

513

396

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Postpartum depression (PPD) adversely affects the health and well being of many new mothers, their infants, and their families. A comprehensive understanding of biopsychosocial precursors to PPD is needed to solidify the current evidence base for best practices in translation. We conducted a systematic review of research published from 2000 through 2013 on biological and psychosocial factors associated with PPD and postpartum depressive symptoms. Two hundred fourteen publications based on 199 investigations of 151,651 women in the first postpartum year met inclusion criteria. The biological and psychosocial literatures are largely distinct, and few studies provide integrative analyses. The strongest PPD risk predictors among biological processes are hypothalamic-pituitary-adrenal dysregulation, inflammatory processes, and genetic vulnerabilities. Among psychosocial factors, the strongest predictors are severe life events, some forms of chronic strain, relationship quality, and support from partner and mother. Fully integrated biopsychosocial investigations with large samples are needed to advance our knowledge of PPD etiology.

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“…The driving of the precursor tryptophan down the kyn pathway and away from serotonin and melatonin production is crucial to lowering serotonin in MDD. Single nucleotide polymorphisms (SNPs) in the serotonin rate-limiting enzyme tryptophan hydroxylase 2 (TPH2) gene are linked to increased depression during pregnancy as well as postnatally 28. Depressive and anxiety symptoms in the early postnatal period are also linked to a rise in the kyn/tryptophan ratio,29 with increases in the proinflammatory cytokines interleukin (IL)-6 and tumor necrosis factor (TNF)-á in the cerebral spinal fluid at delivery also evident, indicative of elevated central immuno-inflammatory activity 30.…”

Section: Immunological Conceptualizations Of Depressionmentioning

confidence: 99%

Postpartum depression: psychoneuroimmunological underpinnings and treatment

Anderson¹,

Maes²

2013

NDT

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Postpartum depression (PPD) is common, occurring in 10%–15% of women. Due to concerns about teratogenicity of medications in the suckling infant, the treatment of PPD has often been restricted to psychotherapy. We review here the biological underpinnings to PPD, suggesting a powerful role for the tryptophan catabolites, indoleamine 2,3-dixoygenase, serotonin, and autoimmunity in mediating the consequences of immuno-inflammation and oxidative and nitrosative stress. It is suggested that the increased inflammatory potential, the decreases in endogenous anti-inflammatory compounds together with decreased omega-3 poly-unsaturated fatty acids, in the postnatal period cause an inflammatory environment. The latter may result in the utilization of peripheral inflammatory products, especially kynurenine, in driving the central processes producing postnatal depression. The pharmacological treatment of PPD is placed in this context, and recommendations for more refined and safer treatments are made, including the better utilization of the antidepressant, and the anti-inflammatory and antioxidant effects of melatonin.

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Genetic variants in the tryptophan hydroxylase 2 gene (TPH2) and depression during and after pregnancy

Cited by 47 publications

References 71 publications

The Influence of genetic factors on peripartum depression: A systematic review

The Influence of genetic factors on peripartum depression: A systematic review

Biological and Psychosocial Predictors of Postpartum Depression: Systematic Review and Call for Integration

Postpartum depression: psychoneuroimmunological underpinnings and treatment

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