Genetic Variation of BCL2 (rs2279115), NEIL2 (rs804270), LTA (rs909253), PSCA (rs2294008) and PLCE1 (rs3765524, rs10509670) Genes and Their Correlation to Gastric Cancer Risk Based on Universal Tagged Arrays and Fe&lt;SUB&gt;3&lt;/SUB&gt;O&lt;SUB&gt;4&lt;/SUB&gt; Magnetic Nanoparticles

Mou, Xianbo; Li, Taotao; Wang, Jiuhai; Ali, Zeeshan; Zhang, Yuanying; Chen, Zhu; Deng, Yan; Song, Li; Su, Enben; Jia, Qiongying; He, Nongyue; Ni, Jian; Cui, Daxiang

doi:10.1166/jbn.2015.2113

Cited by 53 publications

(26 citation statements)

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“…We also detected a strong LD(r 2 =1) between rs2274223 and rs3765524 in the CHB population and Chinese HBV-related HCC patients. A genome-wide association pathway analysis found that rs3765524 contributed to GC susceptibility [81, 82], while a case-control study of the Chinese population showed that rs3765524 was associated with disease risk in GC and ESCC [58, 67, 83]. Investigations of South Asian patients showed similar results for GC [72] but not for ESCC [78, 84].…”

Section: Discussionmentioning

confidence: 99%

PLCE1 polymorphisms and expression combined with serum AFP level predicts survival of HBV-related hepatocellular carcinoma patients after hepatectomy

et al. 2017

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Polymorphisms in the phospholipase C epsilon (PLCE) 1 gene play a crucial role in the development and progression of several types of cancer. The present study investigated the prognostic significance of PLCE1 gene polymorphisms and expression combined with serum α-fetoprotein (AFP) level in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Single nucleotide polymorphisms were genotyped by sequencing DNA isolated from surgically resected tumor samples of 421 HBV-related HCC patients, and expression profiles were generated based on the GSE14520 dataset. A joint-effects analysis of PLCE1 haplotypes (Ars2274223Crs3765524; Grs2274223Trs3765524) with AFP level stratified at 20 ng/ml showed a significant association with overall survival(OS) of HBV-related HCC patients(log-rank P=0.0003). Patients with AC and GT haplotypes with AFP level ≥ 20 ng/ml had an increased risk of death as compared to those with the AC haplotype and AFP level < 20 ng/ml (adjusted P=0.029 and 0.041, respectively). Patients with the GT haplotype and AFP level < 20 ng/ml also had an increased risk of death, although with a non-significant P value (adjusted P=0.092). Joint-effects analysis of PLCE1 mRNA expression with serum AFP level stratified at 300 ng/ml was significantly associated with HBV-related HCC recurrence and OS. Our results demonstrate that PLCE1 haplotypes (including rs2274223 and rs3765524) and expression combined with serum AFP level may predict postoperative outcome of HBV-related HCC patients.

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Section: Discussionmentioning

confidence: 99%

PLCE1 polymorphisms and expression combined with serum AFP level predicts survival of HBV-related hepatocellular carcinoma patients after hepatectomy

et al. 2017

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“…The application of magnetic nanoparticles for DNA and RNA isolation, also known Copyright: American Scientific Publishers as magnetic nucleic acids separation technology, has been widely accepted as a reliable method. [23][24][25][26][27][28][29][30][31][32] Automations based on this method had gained much attention. 17 20 33-35 However, those existing robotic solutions based on this technology are still far from perfect.…”

Section: Discussionmentioning

confidence: 99%

Multifunctional Device for Nucleic Acid Extraction Based on Magnetic Separation and Its Co-Working with Liquid Handling System for High Throughput Sample Preparation

Wu¹,

Hui²,

Zhu³

et al. 2016

j nanosci nanotechnol

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The use of magnetic nanoparticles (MNPs) in sample preparation has gained much attention. Easyto-handle property of MNPs has provided a great promising solution for lab automation. Laboratory robotics and workstations based on magnetic separation are in rapid development process, and increasing efforts are debited for their practical applications in clinical methods. To increase the processing throughput and reduce the risk of cross contamination, we developed a multifunctional module to optimize the workflow of magnetic nucleic acid separation in automated workstation. Three functions (magnetic separation, heating, and shaking) were elaborately combined into this device, by which the 96-well plate-based sample preparation can be completed on site without transferring the plate to other auxiliary modules. Test experiments were carried out on this platform. It was shown that this multifunctional device could cooperate well with our pipetting system, and this new platform exhibited its ability to meet the demands for high-throughput sample preparation.

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“…Totally 200 pathological samples and 134 normal control subjects were collected. The results demonstrated that four SNP loci (rs2279115, rs804270, rs909253 and rs3765524) showed a potential association with gastric cancer risk, and the other two (rs2294008, rs10509670) possessed no difference/association among cases and controls [16]. The four SNP sites own potential in applications such as gastric cancer risk predication.…”

Section: Pre-warning Gastric Cancer Patients By Snps Arraysmentioning

confidence: 93%

Advance and Prospects of Nanotheranostic Technology for Gastric Cancer

Cui¹,

Ma²,

Zhi³

et al. 2016

Nano BioMed ENG

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Over the past few years, gastric cancer prewarning and early theranostic system have achieved great advances. Gastric cancer theranostic strategies still focus on prediction and prewarning of early gastric cancer, early diagnosis and molecular imaging directed operation therapy, enhanced immunotherapy and killing gastric cancer stem cells to overcome multidrug resistance (MDR). Here we review the main advances in this field over the past few years, explore the clinical translational prospects, and discuss the concepts, issues, approaches, and challenges, with the aim of stimulating a broader interest in developing gastric cancer prewarning and early theranostic system and promoting clinical translation.

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Genetic Variation of BCL2 (rs2279115), NEIL2 (rs804270), LTA (rs909253), PSCA (rs2294008) and PLCE1 (rs3765524, rs10509670) Genes and Their Correlation to Gastric Cancer Risk Based on Universal Tagged Arrays and Fe<SUB>3</SUB>O<SUB>4</SUB> Magnetic Nanoparticles

Cited by 53 publications

References 0 publications

PLCE1 polymorphisms and expression combined with serum AFP level predicts survival of HBV-related hepatocellular carcinoma patients after hepatectomy

PLCE1 polymorphisms and expression combined with serum AFP level predicts survival of HBV-related hepatocellular carcinoma patients after hepatectomy

Multifunctional Device for Nucleic Acid Extraction Based on Magnetic Separation and Its Co-Working with Liquid Handling System for High Throughput Sample Preparation

Advance and Prospects of Nanotheranostic Technology for Gastric Cancer

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