2009
DOI: 10.1038/jhg.2009.58
|View full text |Cite
|
Sign up to set email alerts
|

Genetic variation of genes for xenobiotic-metabolizing enzymes and risk of bronchial asthma: the importance of gene–gene and gene–environment interactions for disease susceptibility

Abstract: The aim of our pilot study was to evaluate the contribution of genes for xenobiotic-metabolizing enzymes (XMEs) for the development of bronchial asthma. We have genotyped 25 polymorphic variants of 18 key XME genes in 429 Russians, including 215 asthmatics and 214 healthy controls by a polymerase chain reaction, followed by restriction fragment length polymorphism analyses. We found for the first time significant associations of CYP1B1 V432L (P¼0.045), PON1 Q192R (P¼0.039) and UGT1A6 T181A (P¼0.025) gene polym… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2

Citation Types

3
20
1
3

Year Published

2010
2010
2022
2022

Publication Types

Select...
6
1

Relationship

1
6

Authors

Journals

citations
Cited by 37 publications
(27 citation statements)
references
References 51 publications
3
20
1
3
Order By: Relevance
“…The distribution of null genotypes of GSTM1 and GSTT1 genes among patients with idiopathic male infertility and healthy control subjects are presented in Table 1. The frequencies of GSTM1 and GSTT1 null genotypes in the control group were similar to those we described earlier in a Russian population of the Kursk region (12). As can be seen from Table 1, there was no difference in the frequency of GSTM1 null genotype between patients with idiopathic infertility and fertile men.…”
supporting
confidence: 84%
“…The distribution of null genotypes of GSTM1 and GSTT1 genes among patients with idiopathic male infertility and healthy control subjects are presented in Table 1. The frequencies of GSTM1 and GSTT1 null genotypes in the control group were similar to those we described earlier in a Russian population of the Kursk region (12). As can be seen from Table 1, there was no difference in the frequency of GSTM1 null genotype between patients with idiopathic infertility and fertile men.…”
supporting
confidence: 84%
“…The allele and genotype frequencies of the NAT2 polymorphisms in each study group satisfied the HardyWeinberg equilibrium law. The frequencies of alleles and genotypes of both SNP were comparable to those previously reported in Kursk population (Polonikov et al, 2009b). As can be seen from Table 1, no significant difference in allele and genotype frequencies of NAT2 were found between idiopathic male infertility patients and healthy men.…”
Section: Discussionsupporting
confidence: 75%
“…Power calculations were based on the NAT2 allele and genotype frequencies previously investigated in Kursk population (Polonikov et al, 2009b). This work was able to detect a difference of 10-18% between groups with power of 75% and a 5% type I error on the basis of sample sizes for each subgroup analysis.…”
Section: Discussionmentioning
confidence: 99%
“…They report that apart from lowering enzyme activity, the T113C variant also upregulates another gene (ORMDL3), which has been associated with risk of childhood asthma [42]. A recent pilot study also emphasises the multifactorial nature of bronchial asthma, reporting that gene-gene and gene-environment interactions involving EPHX1 are important determinants of asthma susceptibility [38]. We were not able to evaluate as many interactions as were in that study.…”
Section: Asthmamentioning
confidence: 45%
“…Although the clinical manifestations of asthma and COPD are different, some of the same environmental factors may trigger both disease states [6,38]. Genetic variations in xenobioticmetabolising enzymes such as EPHX1 have been found to modify asthma susceptibility [39,40].…”
Section: Asthmamentioning
confidence: 99%