Genetic variations of ND5 gene of mtDNA in populations of Anopheles sinensis (Diptera: Culicidae) malaria vector in China

Makhawi, Abdelrafie M.; Liu, Xiaobo; Yang, Shuran; Liu, Qiyong

doi:10.1186/1756-3305-6-290

Cited by 24 publications

(21 citation statements)

References 46 publications

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“…It was obvious that the YN population of An. sinensis was relatively unique in this study as in other reports [16, 46]. The finding also reported that there was a great difference between YN and other populations in the pyrethroid resistance mechanism [47, 50].…”

Section: Discussionsupporting

confidence: 68%

Genetic diversity and population structure of the primary malaria vector Anopheles sinensis (Diptera: Culicidae) in China inferred by cox1 gene

et al. 2017

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Background Anopheles sinensis is a primary vector for Plasmodium vivax malaria in most regions of China. A comprehensive understanding of genetic variation and structure of the mosquito would be of benefit to the vector control and in a further attempt to contribute to malaria elimination in China. However, there is only inadequate population genetic data pertaining to An. sinensis currently.MethodsGenetic variations and structure among populations of An. sinensis was examined and analyzed based on the nucleotide sequences of a 662 nt variable region of the mitochondrial cox1 gene among 15 populations from 20 collection sites in China.ResultsA total of 453 individuals in 15 populations were analyzed. The cox1 gene sequences were aligned, and 247 haplotypes were detected, 41 of these shared between populations. The range of haplotype diversity was from 0.709 (Yunnan) to 0.998 (Anhui). The genealogic network showed that the haplotypes were divided into two clusters, cluster I was at a high level of homoplasy, while cluster II included almost all individuals from the Yunnan population. The Yunnan population displayed a significantly high level of genetic differentiation (0.452−0.622) and a restricted gene flow with other populations. The pairwise F ST values among other populations were lower. The AMOVA result showed that the percentage of variation within populations (83.83%) was higher than that among populations (16.17%). Mantel test suggested that geographical distance did not significantly contribute to the genetic differentiation (R 2 = 0.0125, P = 0.59). Neutral test and mismatch analysis results showed that the An. sinensis population has undergone demographic expansions.Conclusions Anopheles sinensis populations showed high genetic polymorphism by cox1 gene. The weak genetic structure may be a consequence of low genetic differentiation and high gene flow among populations, except the Yunnan samples. The Yunnan population was isolated from the other populations, gene flow limited by geographical distance and barriers. These findings will provide a theoretical basis for vector surveillance and vector control in China.Electronic supplementary materialThe online version of this article (doi:10.1186/s13071-017-2013-z) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 68%

Genetic diversity and population structure of the primary malaria vector Anopheles sinensis (Diptera: Culicidae) in China inferred by cox1 gene

et al. 2017

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“…The genetic diversity results, with all Pi values being less than 0.01, indicate that S. erinaceieuropaei isolates in eastern China have low genetic variation (Neigel and Avise, 1993). Generally, the results of pairwise F ST values showed that there is moderate-to-high genetic differentiation within different populations (F ST > 0.15), indicating that the gene flow among these S. erinaceieuropaei populations has probably been interrupted over the long term (Balloux and Lugon-Moulin, 2002;Makhawi et al, 2013;Zhao et al, 2013). Under the assumption of neutrality, a population expansion produces a negative value of Tajima's D and Fu's F S tests (Tajima, 1989;Fu, 1997); therefore, the results of neutrality tests support the possible population expansion in S. erinaceieuropaei from eastern China.…”

Section: Discussionmentioning

confidence: 96%

Characterisation of the relationship between Spirometra erinaceieuropaei and Diphyllobothrium species using complete cytb and cox1 genes

Zhang

Wang

Cui

et al. 2015

Infection, Genetics and Evolution

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“…However, the main vector for P. vivax is An. sinensis in mainland China [ 43 ]. It is evident that the development of An.…”

Section: Discussionmentioning

confidence: 99%

Malaria incidence from 2005–2013 and its associations with meteorological factors in Guangdong, China

Guo

Yang

et al. 2015

Malar J

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BackgroundThe temporal variation of malaria incidence has been linked to meteorological factors in many studies, but key factors observed and corresponding effect estimates were not consistent. Furthermore, the potential effect modification by individual characteristics is not well documented. This study intends to examine the delayed effects of meteorological factors and the sub-population’s susceptibility in Guangdong, China.MethodsThe Granger causality Wald test and Spearman correlation analysis were employed to select climatic variables influencing malaria. The distributed lag non-linear model (DLNM) was used to estimate the non-linear and delayed effects of weekly temperature, duration of sunshine, and precipitation on the weekly number of malaria cases after controlling for other confounders. Stratified analyses were conducted to identify the sub-population’s susceptibility to meteorological effects by malaria type, gender, and age group.ResultsAn incidence rate of 1.1 cases per 1,000,000 people was detected in Guangdong from 2005–2013. High temperature was associated with an observed increase in malaria incidence, with the effect lasting for four weeks and a maximum relative risk (RR) of 1.57 (95% confidence interval (CI): 1.06-2.33) by comparing 30°C to the median temperature. The effect of sunshine duration peaked at lag five and the maximum RR was 1.36 (95% CI: 1.08-1.72) by comparing 24 hours/week to 0 hours/week. A J-shaped relationship was found between malaria incidence and precipitation with a threshold of 150 mm/week. Over the threshold, precipitation increased malaria incidence after four weeks with the effect lasting for 15 weeks, and the maximum RR of 1.55 (95% CI: 1.18-2.03) occurring at lag eight by comparing 225 mm/week to 0 mm/week. Plasmodium falciparum was more sensitive to temperature and precipitation than Plasmodium vivax. Females had a higher susceptibility to the effects of sunshine and precipitation, and children and the elderly were more sensitive to the change of temperature, sunshine duration, and precipitation.ConclusionTemperature, duration of sunshine and precipitation played important roles in malaria incidence with effects delayed and varied across lags. Climatic effects were distinct among sub-groups. This study provided helpful information for predicting malaria incidence and developing the future warning system.Electronic supplementary materialThe online version of this article (doi:10.1186/s12936-015-0630-6) contains supplementary material, which is available to authorized users.

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Genetic variations of ND5 gene of mtDNA in populations of Anopheles sinensis (Diptera: Culicidae) malaria vector in China

Cited by 24 publications

References 46 publications

Genetic diversity and population structure of the primary malaria vector Anopheles sinensis (Diptera: Culicidae) in China inferred by cox1 gene

Genetic diversity and population structure of the primary malaria vector Anopheles sinensis (Diptera: Culicidae) in China inferred by cox1 gene

Characterisation of the relationship between Spirometra erinaceieuropaei and Diphyllobothrium species using complete cytb and cox1 genes

Malaria incidence from 2005–2013 and its associations with meteorological factors in Guangdong, China

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