Geniposide Ameliorated Dexamethasone-Induced Cholesterol Accumulation in Osteoblasts by Mediating the GLP-1R/ABCA1 Axis

Zheng, Yizhou; Xiao, Yaosheng; Zhang, Di; Zhang, Shanshan; Ouyang, J.; Li, Linfu; Shi, Weimei; Zhang, Rui; Liu, Hai; Qi, Jin; Chen, Zhixi; Xu, Daohua; Wu, Longhuo

doi:10.3390/cells10123424

Cited by 20 publications

(12 citation statements)

References 51 publications

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“…Studies have also confirmed that wogonin may have beneficial effects in ameliorating dyslipidemia via PPAR α activation. Furthermore, other compounds of HLJDD also have the function of regulating dyslipidemia, such as crocetin [ 30 ], baicalein [ 31 ], and geniposide [ 32 ]. Together, they form a network that embodies the multicompound role of the TCM decoction in regulating dyslipidemia.…”

Section: Discussionmentioning

confidence: 99%

Study on the Mechanism of Huanglian Jiedu Decoction in Treating Dyslipidemia Based on Network Pharmacology

Gong

Chen

et al. 2022

Journal of Healthcare Engineering

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Objective. This study aimed to determine the active ingredients of Huanglian Jiedu decoction (HLJDD) and the targets for treating dyslipidemia through network pharmacology to facilitate further application of HJJDD in the treatment of dyslipidemia. Methods. Potential drug targets for dyslipidemia were identified with a protein-protein interaction network. Gene ontology (GO) enrichment analysis and KEGG pathway analysis were performed to elucidate the biological function and major pathways involved in the HLJDD-mediated treatment of dyslipidemia. Results. This approach revealed 22 components, 234 targets of HLJDD, and 221 targets of dyslipidemia. There were 14 components and 31 common targets between HLJDD and dyslipidemia treatment. GO enrichment analysis showed that these targets were mainly associated with the response to DNA-binding transcription factor activity, lipid localization and storage, reactive oxygen species metabolic process, and inflammatory response. The results of KEGG analysis indicated that the AGE-RAGE, NF-κB, HIF-1, IL-17, TNF, FoxO, and PPAR signalling pathways were enriched in the antidyslipidemic action of HLJDD. Conclusion. This study expounded the pharmacological actions and molecular mechanisms of HLJDD in treating dyslipidemia from a holistic perspective, which may provide a scientific basis for the clinical application of HLJDD.

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Section: Discussionmentioning

confidence: 99%

Study on the Mechanism of Huanglian Jiedu Decoction in Treating Dyslipidemia Based on Network Pharmacology

Gong

Chen

et al. 2022

Journal of Healthcare Engineering

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“…Both osteoblasts and adipocytes are differentiated from BMSCs. Glucocorticoid-induced lipid accumulation has been demonstrated to be negative to bone mass ( Zheng et al, 2021 ). It is evident that bone loss increases with ageing.…”

Section: The Protective Activity Of Genistein Against Bone and Cartil...mentioning

confidence: 99%

The protective activity of genistein against bone and cartilage diseases

Liu

2022

Front. Pharmacol.

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Genistein, a natural isoflavone rich in soybean and leguminous plants, has been shown various biological effects, such as anti-inflammation, anti-oxidation, anti-cancer, and bone/cartilage protection. Due to the structural similarity to estrogen, genistein exhibits estrogen-like activity in protecting against osteoporosis and osteoarthritis. Furthermore, genistein has been considered as an inhibitor of tyrosine kinase, which has been found to be dysregulated in the pathological development of osteoporosis, osteoarthritis, and intervertebral disc degeneration (IDD). Many signaling pathways, such as MAPK, NF-κB, and NRF2/HO-1, are involved in the regulatory activity of genistein in protecting against bone and cartilage diseases. The potential molecular mechanisms of genistein in therapeutic management of bone and cartilage diseases have been investigated, but remain to be fully understood. In this article, we mainly discuss the current knowledge of genistein in protecting against bone and cartilage diseases, such as osteoporosis, osteoarthritis, rheumatoid arthritis (RA), and IDD.

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“…In addition, geniposide ameliorated DEX-induced cholesterol accumulation in MC3T3-E1 cells and inhibited cell differentiation through modulating the GLP-1R/ABCA1 axis. Moreover, geniposide improved DEX-induced OP by activating GLP-1R expression in vivo and in vitro [ 35 ]. In addition, geniposide has the function of anti-skeletal muscle fibrosis.…”

Section: Effect Of Geniposide On Osteoporosismentioning

confidence: 99%

Updated Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of Natural Product Geniposide

Liu

Chen

et al. 2022

Molecules

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At present, the potential of natural products in new drug development has attracted more and more scientists’ attention, and natural products have become an important source for the treatment of various diseases or important lead compounds. Geniposide, as a novel iridoid glycoside compound, is an active natural product isolated from the herb Gardenia jasminoides Ellis (GJ) for the first time; it is also the main active component of GJ. Recent studies have found that geniposide has multiple pharmacological effects and biological activities, including hepatoprotective activity, an anti-osteoporosis effect, an antitumor effect, an anti-diabetic effect, ananti-myocardial dysfunction effect, a neuroprotective effect, and other protective effects. In this study, the latest research progress of the natural product geniposide is systematically described, and the pharmacological effects, pharmacokinetics, and toxicity of geniposide are also summarized and discussed comprehensively. We also emphasize the major pathways modulated by geniposide, offering new insights into the pharmacological effects of geniposide as a promising drug candidate for multiple disorders.

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Geniposide Ameliorated Dexamethasone-Induced Cholesterol Accumulation in Osteoblasts by Mediating the GLP-1R/ABCA1 Axis

Cited by 20 publications

References 51 publications

Study on the Mechanism of Huanglian Jiedu Decoction in Treating Dyslipidemia Based on Network Pharmacology

Study on the Mechanism of Huanglian Jiedu Decoction in Treating Dyslipidemia Based on Network Pharmacology

The protective activity of genistein against bone and cartilage diseases

Updated Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of Natural Product Geniposide

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