Genitourinary complications of systemic lupus erythematosus

Meyers, Kevin; Pfieffer, S.; Lu, Theresa; Kaplan, Bernard S.

doi:10.1007/s004670050786

Cited by 23 publications

(17 citation statements)

References 26 publications

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“…Some human SLE patients have been reported to develop bilateral hydronephrosis with concomitant inflammation along the urinary tract ( 15 ). Interstitial cystitis is also one of the main complications in SLE and Sjogren's syndrome ( 16 , 17 ). BALB/c- Fcgr2b −/− Pdcd1 −/− mice may thus serve as a good animal model of such complications.…”

Section: Resultsmentioning

confidence: 99%

Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b −/− Pdcd1 −/− mice

Okazaki

Otaka

Wang

et al. 2005

The Journal of Experimental Medicine

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Because most autoimmune diseases are polygenic, analysis of the synergistic involvement of various immune regulators is essential for a complete understanding of the molecular pathology of these diseases. We report the regulation of autoimmune diseases by epistatic effects of two immunoinhibitory receptors, low affinity type IIb Fc receptor for IgG (FcγRIIB) and programmed cell death 1 (PD-1). Approximately one third of the BALB/c-Fcgr2b −/− Pdcd1 −/− mice developed autoimmune hydronephrosis, which is not observed in either BALB/c-Fcgr2b −/− or BALB/c-Pdcd1 −/− mice. Hydronephrotic mice produced autoantibodies (autoAbs) against urothelial antigens, including uroplakin IIIa, and these antibodies were deposited on the urothelial cells of the urinary bladder. In addition, ∼15% of the BALB/c-Fcgr2b −/− Pdcd1 −/− mice produced antinuclear autoAbs. In contrast, the frequency of the autoimmune cardiomyopathy and the production of anti–parietal cell autoAb, which were observed in BALB/c-Pdcd1 −/− mice, were not affected by the additional FcγRIIB deficiency. These observations suggest cross talk between two immunoinhibitory receptors, FcγRIIB and PD-1, on the regulation of autoimmune diseases.

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Section: Resultsmentioning

confidence: 99%

Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b −/− Pdcd1 −/− mice

Okazaki

Otaka

Wang

et al. 2005

The Journal of Experimental Medicine

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“…Affected vessels were said to be the arterial vessels in 1 of the 2 patients and small vessels in the other, whereas there was no mention of the ovarian veins. Ovarian vasculitis has been described in a young patient with aCL‐positive SLE (12). However, clinical, imaging, and pathologic features of these cases were clearly distinct from those of the present report .…”

Section: Discussionmentioning

confidence: 99%

Total RNA yield and microarray gene expression profiles from fine‐needle aspiration biopsy and core‐needle biopsy samples of breast carcinoma

Symmans

Ayers

Clark

et al. 2003

Cancer

164

118

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BACKGROUNDGene expression profiling should be applicable to needle biopsy samples if microarray technology is to become practically useful for clinical research or management of breast carcinoma. This study compared gene expression profiles derived from fine‐needle aspiration biopsy (FNAB) and from core needle biopsy (CBX).METHODSTotal RNA was extracted from single FNAB and CBX samples. Corresponding pairs of FNAB and CBX were analyzed for similarity of gene expression profiles using cDNA microarrays that contain 30,721 human sequences. A subset of genes that distinguished CBX samples from FNAB samples was evaluated in a larger group of needle biopsy samples and in a published genomic database derived from 78 sporadic breast carcinomas with known clinical outcome.RESULTSSixty‐eight patients with newly diagnosed breast carcinoma were included in the current study. Sixty‐five patients underwent FNAB (17 had both FNAB and CBX) and 3 underwent CBX only. Extracted RNA was of suitable quality for hybridization in 46 (71%) FNABs and 15 (75%) CBXs. Total RNA yield in those samples was similar for single‐pass FNAB (mean = 3.6 μg and median = 2.2 μg; n = 46) and CBX (mean = 2.8 μg and median = 2.0 μg; n = 15), with 1 μg or more of total RNA in all cases. Transcriptional profiling was performed successfully in all cases when it was attempted, in a total of 50 samples (38 FNABs and 12 CBXs), including matched FNAB and CBX samples from 10 patients. There were differences in gene expression profiles in 10 matched FNAB and CBX sample pairs. Genes that were expressed differently in CBX samples, compared with FNAB samples, were recognized as being predominantly from the endothelium, fibroblasts, myofibroblasts or smooth muscle, and histiocytes. Corresponding microscopic cell counts from FNABs demonstrated means of 80% tumor cells, 15% lymphocytes, and 5% stromal cells, whereas CBXs contained 50% tumor cells, 20% lymphocytes, and 30% stromal cells. Considering that CBXs are approximately six‐fold richer in nonlymphoid stromal cells than FNABs and that CBXs differentially express a set of recognized stromal genes, the authors used these biopsies to define a transcriptional profile of breast carcinoma stroma. A set of 120 genes differentially expressed in CBXs was assessed independently in a published breast carcinoma genomic database to classify breast carcinomas based on stromal gene expression. Subgroups of tumors with low or high stromal signal were identified, but there was no correlation with the development of systemic metastases within 5 years.CONCLUSIONSBoth FNAB and CBX yield a similar quality and quantity of total RNA and are suitable for cDNA microarray analyses in approximately 70–75% of single‐pass samples. Transcriptional profiles from FNAB and CBX of the same tumor generally are similar and are driven by the tumor cell population. The authors concluded that each technique has relative advantages. The FNABs provide transcriptional profiles that are a purer representation of the tumor cell population, whereas transcriptional profiles from CBXs include more repre sentation from nonlymphoid stromal elements. Selection of the preferred needle biopsy sampling technique for genomic studies of breast carcinomas should depend on whether variable stromal gene expression is desirable in the samples. Cancer 2003;97:2960–71. © 2003 American Cancer Society.DOI 10.1002/cncr.11435

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“…There have been a few reports of genitourinary symptoms, such as pericapsular renal bleeding, adrenal hemorrhage, or hemorrhagic cystitis with secondary APS [6, 7]. Various renal complications, including renal artery or venous thrombosis, renal infarct, hypertension, renal failure, and various glomerular lesions, have been reported as APS nephropathy [8].…”

Section: Discussionmentioning

confidence: 99%

Severe Renal Hemorrhage in a Pregnant Woman Complicated with Antiphospholipid Syndrome: A Case Report

Kawaguchi

Izumi

Nohara

et al. 2011

Advances in Urology

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Antiphospholipid syndrome is a systemic autoimmune disease with thrombotic tendency. Consensus guidelines for pregnancy with antiphospholipid syndrome recommend low-dose aspirin combined with unfractionated or low-molecular-weight heparin because antiphospholipid syndrome causes habitual abortion. We report a 36-year-old pregnant woman diagnosed with antiphospholipid syndrome receiving anticoagulation treatment. The patient developed left abdominal pain and gross hematuria at week 20 of pregnancy. An initial diagnosis of left ureteral calculus was made. Subsequently abdominal-pelvic computed tomography was required for diagnosis because of the appearance of severe contralateral pain. Computed tomography revealed serious renal hemorrhage, and ureteral stent placement and pain control by patient-controlled analgesia were required. After treatment, continuance of pregnancy was possible and vaginal delivery was performed safely. This is the first case report of serious renal hemorrhage in a pregnant woman with antiphospholipid syndrome receiving anticoagulation treatment and is an instructive case for urological and obstetrical practitioners.

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Genitourinary complications of systemic lupus erythematosus

Cited by 23 publications

References 26 publications

Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b −/− Pdcd1 −/− mice

Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b −/− Pdcd1 −/− mice

Total RNA yield and microarray gene expression profiles from fine‐needle aspiration biopsy and core‐needle biopsy samples of breast carcinoma

Severe Renal Hemorrhage in a Pregnant Woman Complicated with Antiphospholipid Syndrome: A Case Report

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