Genogroup I picobirnavirus in diarrhoeic foals: Can the horse serve as a natural reservoir for human infection?

Ganesh, Balasubramanian; Bányai, Krisztiàn; Masachessi, Gisela; Mladenova, Z.; Nagashima, Shigeo; Ghosh, Souvik; Nataraju, Seegekote Mariyappa; Pativada, Madhusudhan; Kumar, Rahul; Kobayashi, Nobumichi

doi:10.1186/1297-9716-42-52

Cited by 30 publications

(37 citation statements)

References 28 publications

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“…The PBV strains detected among children in Kolkata, India were reported to be closely related to porcine PBV strains [28,29]. Similarly, the equine PBV strains detected and sequenced from feces of domestic foals in Kolkata, India [30] showed genetic relationship with earlier reported human PBV strains of the same region [28] as well as PBV strains of environmental samples (raw sewage, treated effluent and river water/surface water) reported from the USA [72].…”

Section: Discovery Of Picobirnavirusmentioning

confidence: 58%

“…Later, PBVs have been identified in faecal specimens of humans practically worldwide [3, 6, 7, 14, 26-29, 51, 55, 56, 61, 68, 76]. PBVs were also detected in faeces of a wide variety of farm mammals, birds, wild animals and birds kept in captivity, etc., viz., pigs [2,4,16,31,34,50,56,67], calves [10,15,35,53,54,61,77,79], rabbits and guinea pigs [25,43,52,65], bats [86], red fox [8], avian such as chickens & poults [1,49,59,69,73], and other wild animals kept in captivity like Giant Anteaters [45]; giant cats like Lion, Puma, Jaguar and Geoffroy's cat [37], sea lion [84], human primates such as Orangutan, wild birds such as American Ostrich, gloomy pheasant, Chinese goose [57], goat kids and lambs [60], donkeys [57,58], foals [9,30], laboratory non-human primates such as rhesus, pigtailed macaques and cynomolgus monkeys [83] and dogs [17,23,81], rats [23,64], snakes [23] and turkeys …”

Section: Discovery Of Picobirnavirusmentioning

confidence: 99%

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Animal Picobirnavirus

2014

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Picobirnavirus (PBV) is a small, non-enveloped, bisegmented double-stranded RNA (dsRNA) virus of vertebrate hosts. The name 'Picobirnavirus' derives from the prefix 'pico' (latin for 'small') in reference to the small virion size, plus the prefix 'bi' (latin for 'two') and the word 'RNA' to indicate the nature of the viral genome. The serendipitous discovery of PBV dates back to 1988 from Brazil, when human fecal samples collected during the acute gastroenteritis outbreaks were subjected for routine rotavirus surveillance by polyacrylamide gel electrophoresis (PAGE) and silver straining (S/S). The PAGE gels after silver staining showed a typical 'two RNA band' pattern, and it was identified as Picobirnavirus. Likewise, the feces of wild black-footed pigmy rice rats (Oryzomys nigripes) subjected for PAGE assay by the same research group in Brazil reported the presence of PBV (Pereira et al., J Gen Virol 69:2749-2754. PBVs have been detected in faeces of humans and wide range of animal species with or without diarrhoea, worldwide. The probable role of PBV as either a 'primary diarrhoeal agent' in 'immunocompetent children'; or a 'potential pathogen' in 'immunocompromised individuals' or an 'innocuous virus' in the intestine remains elusive and needs to be investigated despite the numerous reports of the presence of PBV in fecal samples of various species of domestic mammals, wild animals, birds and snakes; our current knowledge of their biology, etiology, pathogenicity or their transmission characteristics remains subtle. This review aims to analyse the veterinary and zoonotic aspects of animal Picobirnavirus infections since its discovery.

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Section: Discovery Of Picobirnavirusmentioning

confidence: 58%

Section: Discovery Of Picobirnavirusmentioning

confidence: 99%

Animal Picobirnavirus

2014

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“…With the advancement of molecular diagnostic techniques such as RT-PCR (Ganesh et al, 2012;Malik et al, 2013;Takiuchi et al, 2016) and qRT-PCR (Malik, unpublished data) for picobirnaviruses, they have been detected in faecal and respiratory samples from over 20 animal species including rodents, aves and large animals like rats, hamsters, guinea pigs, giant ant eater, dogs, pigs, bovine calves, buffalo calves, foals camels, snakes worldwide and exhibit vast genetic diversity (Ganesh et al, 2011;Malik et al, 2011;Smits et al, 2011;Gillman et al, 2013;Malik et al, 2013;Malik et al, 2014;Ng et al, 2014;Ribeiro et al, 2014;Woo et al, 2014, Verma et al, 2015Takiuchi et al, 2016). Despite the broad host range, pathogenicity of PBVs alone or as co-infecting agents remains unclear.…”

Section: Picobirnavirusmentioning

confidence: 99%

“…In equines, PBVs have been reported for the first time in the year 1991 in foals in Ireland and Britain (Browning et al, 1991b), followed by the RT-PCR detection in a female foal from Kolkata, India (Ganesh et al, 2011). Recently, equine PBVs co-infections were detected in plasma of a horse showing depression, loss of appetite (Li et al, 2015).…”

Section: Picobirnavirusmentioning

confidence: 99%

Evolving views on enteric viral infections of equines: an appraisal of key pathogens

Sircar¹,

Saurabh²,

Kattoor³

et al. 2016

JEBAS

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Equines, the earliest known mammalian species, have been found highly susceptible to several enteric pathogens including viruses, fungi, parasites and bacteria. This review conserves with the key viral pathogens that affects foals and horses such as rotavirus, adenovirus, coronavirus, parvovirus, picobirnavirus etc. With the advent of next generation sequencing approaches the list of new enteric viruses has expanded. Viruses like Cyclovirus, Kirkovirus and Anellovirus are the new members identified in equines recently. Close proximity of horses to human settlements and/or other domestic animals pretense the threat of infectious diseases spread to humans/animals and vice-versa. Therefore, horse diseases are not only of veterinary importance but also are among important factors for public health. Herein, we intend to appraise current status of key enteric viruses that cause diarrheic disorders in foals and horses.

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“…Evidence for genetic relatedness was reported between human and animal PBVs or vice versa [2,5,[16][17][18]22] from around the globe. Genogroup I PBVs detected and sequenced from pigs in Hungary [2] and Venezuela and Argentina [5,22], were observed to be closely related to human genogroup I PBVs.…”

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confidence: 99%

Detection and Molecular Characterization of Porcine Picobirnavirus in Feces of Domestic Pigs from Kolkata, India

et al. 2012

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Picobirnaviruses (PBVs) are small, non-enveloped, 35-41 nm virion with bisegmented double-stranded RNA genome. PBVs are widespread and were detected in feces of humans and a wide variety of animals. Domestic pig, one of the ubiquitous farm animal reported incessant association with a variety of viral zoonoses. The objective of our study is to find out the incidence of PBV infection in healthy domestic pigs. The study was conducted by collecting feces of healthy/asymptomatic pigs from a piggery located in an urban slum at Kolkata, India to detect PBV infections. All the 11 fecal samples were tested by polyacrylamide gel electrophoresis and reverse transcriptionpolymerase chain reaction assay. In this study, we report the first incidence of detection and molecular characterization of porcine PBV (BG-Por-2/2010 and BG-Por-7/ 2010) in feces of domestic pigs from India using the human PBV genogroup I specific primer pair: PicoB25(?) and PicoB43(-). Sequence comparison and phylogenetic analysis of partial RNA-dependent RNA polymerase gene of genome segment 2 revealed genetic relatedness to hitherto reported porcine, murine and human genogroup I PBVs from different geographical regions. This warrants a stringent global surveillance to study the potential zoonotic and emerging PBV infections.

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Genogroup I picobirnavirus in diarrhoeic foals: Can the horse serve as a natural reservoir for human infection?

Cited by 30 publications

References 28 publications

Animal Picobirnavirus

Animal Picobirnavirus

Evolving views on enteric viral infections of equines: an appraisal of key pathogens

Detection and Molecular Characterization of Porcine Picobirnavirus in Feces of Domestic Pigs from Kolkata, India

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