Genome-wide association study for poor sperm motility in Holstein-Friesian bulls

Hering, Dorota; Oleński, Kamil; Kamiński, Stanisław

doi:10.1016/j.anireprosci.2014.01.012

Cited by 87 publications

(67 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Genes underlying the volume of semen and total number of sperm in ejaculate of fertile bulls were not studied. In our earlier work (Hering et al, 2014) we found SNP markers associated with extremely poor sperm motility and suggest some candidate genes involved in this undesirable trait. The aim of this work is to identify markers and candidate genes associated with the variation in semen volume and total number of sperm -traits of high importance for AI stations.…”

Section: Introductionmentioning

confidence: 75%

Genome-wide association study for semen volume and total number of sperm in Holstein-Friesian bulls

Hering

Oleński

Ruść

et al. 2014

Animal Reproduction Science

Self Cite

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 75%

Genome-wide association study for semen volume and total number of sperm in Holstein-Friesian bulls

Hering

Oleński

Ruść

et al. 2014

Animal Reproduction Science

Self Cite

View full text Add to dashboard Cite

“…Based on the Genome-Wise Association Study in bulls we found that the genetic marker rs29011704 located at a distance of 807 214 bp from the SOX5 gene is significantly associated with sperm motility in bulls (Hering et al 2014). As previously noted (Kiselak et al 2010) S-SOX5 (48-kDa SOX5 protein) plays a key role in the formation and function of motile cilia.…”

Section: Introductionmentioning

confidence: 75%

Association between SOX5 Genotypes and Semen Quality in Polish Holstein-Friesian Bulls

Hering¹,

Kamiński²

2016

Polish Journal of Veterinary Sciences

Self Cite

View full text Add to dashboard Cite

The aim of this study was to evaluate the effect of C/T missense mutation (SOX5) gene on selected parameters of non-frozen semen in Polish Holstein -Friesian bulls. Three hundred and sixty eight bulls were genotyped by the PCR-Rsa I technique. Semen was collected and evaluated by standardized procedure used in an AI station. Significant associations were found between SOX5 genotypes and sperm concentrations (p=0.020) and sperm motility (p=0.014). Bulls with TT genotype had the lowest values of both traits. Our results demonstrate that C/T missense mutation within the SOX5 gene is involved in bull sperm quality.

show abstract

“…ksk Within these 25 STRs, we indeed found seven genes which may involve in selection signature: FAM171B, INHBB, TFCP2L1, RPRD2, KLHL1, SP2, and WRN. Three of these loci are of particular interest: INHBB has an important role of inhibin in reproduction (Chu et al 2011;Lee et al 2013); KLHL1 is involved in poor sperm motility in Holstein-Friesian bulls (Shin et al 2014;Hering et al 2014); and WRN gene is related to Werner syndrome (WS), also known as "adult progeria", a rare and autosomal recessive progeroid syndrome (PS), which was characterized by the appearance of premature aging (Doan et al 2012).…”

Section: Selection and Population Genetic Analyses Of Microsatellitesmentioning

confidence: 99%

0309 Systematic profiling of short tandem repeats in the cattle genome

Liu

Haasl

et al. 2016

Journal of Animal Science

View full text Add to dashboard Cite

Short tandem repeats (STRs), or microsatellites, are genetic variants with repetitive 2-6 base pair motifs in many mammalian genomes. Using high-throughput sequencing and experimental validations, we systematically profiled STRs in five Holsteins. We identified a total of 60,106 microsatellites and generated the first high-resolution STR map, representing a substantial pool of polymorphism in dairy cattle. We observed significant STRs overlap with functional genes and quantitative trait loci (QTL). We performed evolutionary and population genetic analyses using over 20,000 common dinucleotide STRs. Besides corroborating the well-established positive correlation between allele size and variance in allele size, these analyses also identified dozens of outlier STRs based on two anomalous relationships that counter expected characteristics of neutral evolution. And one STR locus overlaps with a significant region of a summary statistic designed to detect STR-related selection. Additionally, our results showed that only 57.1% of STRs located within SNP-based linkage disequilibrium (LD) blocks whereas the other 42.9% were out of blocks. Therefore, a substantial number of STRs are not tagged by SNPs in the cattle genome, likely due to STR's distinct mutation mechanism and elevated polymorphism. This study provides the foundation for future STR-based studies of cattle genome evolution and selection.

show abstract

Genome-wide association study for poor sperm motility in Holstein-Friesian bulls

Cited by 87 publications

References 53 publications

Genome-wide association study for semen volume and total number of sperm in Holstein-Friesian bulls

Genome-wide association study for semen volume and total number of sperm in Holstein-Friesian bulls

Association between SOX5 Genotypes and Semen Quality in Polish Holstein-Friesian Bulls

0309 Systematic profiling of short tandem repeats in the cattle genome

Contact Info

Product

Resources

About