2023
DOI: 10.1186/s13148-023-01510-z
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Genome-wide DNA methylation profiling of HPV-negative leukoplakia and gingivobuccal complex cancers

Abstract: Background Gingivobuccal complex oral squamous cell carcinoma (GBC-OSCC) is an aggressive malignancy with high mortality often preceded by premalignant lesions, including leukoplakia. Previous studies have reported genomic drivers in OSCC, but much remains to be elucidated about DNA methylation patterns across different stages of oral carcinogenesis. Results There is a serious lack of biomarkers and clinical application of biomarkers for early dete… Show more

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Cited by 4 publications
(1 citation statement)
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“…The single‐base extension using labelled oligos was detected using Illumina iScan System, and the initial quality review was done using GenomeStudio software. The raw DNA methylation data obtained after scanning the slides have been submitted to the Gene Expression Omnibus (GEO) repository with accession number (Inchanalkar et al., 2023).…”
Section: Methodsmentioning
confidence: 99%
“…The single‐base extension using labelled oligos was detected using Illumina iScan System, and the initial quality review was done using GenomeStudio software. The raw DNA methylation data obtained after scanning the slides have been submitted to the Gene Expression Omnibus (GEO) repository with accession number (Inchanalkar et al., 2023).…”
Section: Methodsmentioning
confidence: 99%