Genomic analysis of
            <i>Drosophila</i>
            chromosome underreplication reveals a link between replication control and transcriptional territories

Belyakin, Stepan N.; Christophides, George K.; Alekseyenko, Artyom A.; Kriventseva, Evgenia V.; Belyaeva, E. S.; Nanayev, Roman A.; Makunin, Igor V.; Kafatos, Fotis C.; Жимулев, И. Ф.

doi:10.1073/pnas.0502702102

Cited by 79 publications

(140 citation statements)

References 29 publications

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“…Global analyses revealed that there is a correlation between replication timing and transcription activity. However, this correlation is not absolute (Schubeler et al 2002;MacAlpine et al 2004;Belyakin et al 2005). Furthermore, similar replication timing profiles were obtained in two human cell types as different as fibroblasts and lymphoblasts, expected to show quite different gene expression profiles (White et al 2004).…”

Section: Role Of the Msl Complex In Transcription Activation And Dosamentioning

confidence: 63%

X-chromosome-wide profiling of MSL-1 distribution and dosage compensation inDrosophila

et al. 2006

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In Drosophila, dosage compensation is achieved by a twofold up-regulation of the male X-linked genes and requires the association of the male-specific lethal complex (MSL) on the X chromosome. How the MSL complex is targeted to X-linked genes and whether its recruitment at a local level is necessary and sufficient to ensure dosage compensation remain poorly understood. Here we report the MSL-1-binding profile along the male X chromosome in embryos and male salivary glands isolated from third instar larvae using chromatin immunoprecipitation ( [Keywords: MSL; X chromosome; chromatin; dosage compensation; transcription] Supplemental material is available at http://www.genesdev.org.

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Section: Role Of the Msl Complex In Transcription Activation And Dosamentioning

confidence: 63%

X-chromosome-wide profiling of MSL-1 distribution and dosage compensation inDrosophila

et al. 2006

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“…The single-cluster embryo low/pupa low (EOpo) program shows reduced expression in pupae, whereas EOpm (four clusters) is highly expressed in pupae and adult males, the latter suggesting expression in the testis (9). EOlh (one cluster) is different in showing high expression in larvae continuing into the pupa.…”

Section: Resultsmentioning

confidence: 93%

Life cycle transcriptome of the malaria mosquito Anopheles gambiae and comparison with the fruitfly Drosophila melanogaster

Koutsos

Blass

Meister

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

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The African mosquito Anopheles gambiae is the major vector of human malaria. We report a genome-wide survey of mosquito gene expression profiles clustered temporally into developmental programs and spatially into adult tissue-specific patterns. Global expression analysis shows that genes that belong to related functional categories or that encode the same or functionally linked protein domains are associated with characteristic developmental programs or tissue patterns. Comparative analysis of our data together with data published from Drosophila melanogaster reveal an overall strong and positive correlation of developmental expression between orthologous genes. The degree of correlation varies, depending on association of orthologs with certain developmental programs or functional groups. Interestingly, the similarity of gene expression is not correlated with the coding sequence similarity of orthologs, indicating that expression profiles and coding sequences evolve independently. In addition to providing a comprehensive view of temporal and spatial gene expression during the A. gambiae life cycle, this large-scale comparative transcriptomic analysis has detected important evolutionary features of insect transcriptomes.comparative transcriptomics ͉ insect development ͉ insect evolution ͉ microarrays A nopheles gambiae is the major vector of human malaria in subSaharan Africa, a secondary vector of filariasis, and the key vector of O'nyong-nyong viral fever outbreaks. Effective transmission of pathogens results from extreme anthropophilic behavior and repeated bloodfeeding of A. gambiae adult females. Indeed, female mosquitoes are found typically around human habitations and bloodfeed largely on humans rather than animals. Therefore, successful malaria control campaigns to date have coincided largely with local control of Anopheles populations.A substantial bloodmeal is required for A. gambiae egg development, the start of the next life cycle. Eggs are fertilized while traversing the genital chamber and begin embryonic development, which normally lasts 2-3 days and is similar to that of Drosophila melanogaster despite notable morphological (1) and molecular (2) differences. Four larval stages (instars) ensue, as compared with three in Drosophila, accompanied by continuous growth. In that period, larval organs are functional and adult organs incipient or slowly developing. During metamorphosis (from larva to pupa and adult) most larval organs are histolyzed, whereas others persist or grow.To date, molecular and cell biological research on A. gambiae has used D. melanogaster as the model system. These dipterans have diverged from a common ancestor Ϸ250 mya.

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“…IH encompasses mostly unique genes and in contrast to PH is repeat-poor. 7 The common theme is IH and PH organization is repressed chromatin state, which is apparently brought about by specific protein complexes. The interplay of HP1-SU(VAR)3-9 core has been shown to be important for PH formation, whereas other protein complexes, including but not limited to Pc-G proteins, contribute to chromatin silencing within IH.…”

confidence: 99%

“…At the DNA sequence level, IH regions are formed by clusters of unique co-late-replicating genes, spanning 100-600 kb. 7 These genes are silent in salivary glands. In polytene chromosome squashes, the chromosomes are frequently observed to break at the IH sites, due to their incomplete polytenization, with every IH region displaying a distinct frequency of breaks.…”

Section: Introductionmentioning

confidence: 99%

Induced decondensation of heterochromatin inDrosophila melanogasterpolytene chromosomes under condition of ectopic expression of theSupressor of underreplicationgene

Колесникова

Semeshin

Andreyeva

et al. 2011

Fly

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Genomic analysis of Drosophila chromosome underreplication reveals a link between replication control and transcriptional territories

Cited by 79 publications

References 29 publications

X-chromosome-wide profiling of MSL-1 distribution and dosage compensation inDrosophila

X-chromosome-wide profiling of MSL-1 distribution and dosage compensation inDrosophila

Life cycle transcriptome of the malaria mosquito Anopheles gambiae and comparison with the fruitfly Drosophila melanogaster

Induced decondensation of heterochromatin inDrosophila melanogasterpolytene chromosomes under condition of ectopic expression of theSupressor of underreplicationgene

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