Genotoxic effects of wastewater from an oncological ward

Degradation of the cytostatic etoposide in chlorinated water by liquid chromatography coupled to quadrupole-Orbitrap mass spectrometry: Identification and quantification of by-products in real water samples

“…However, concern about the occurrence of these compounds in the environment increased during recent years because of their cytotoxic, mutagenic and/or teratogenic properties (Zounkova et al, 2010;Ferk et al, 2009). These compounds are considered as one of the most hazardous contaminants in the water cycle (Seira et al, 2013) and are supposed to be harmful for human and wildlife even at very low doses (Mahnik et al, 2004).…”

Occurrence, Ecotoxicology, and Treatment of Anticancer Agents as Water Contaminants

“…Using adsorptive voltammetry, Kümmerer et al [30] determined the platinum concentration in hospital effluent ranging from 38 to176 ng/L, which was consistent with the annual consumption data. Kiffmeyer et al [6] estimated the biodegradability of cisplatinum using a standard 21 day The potential genotoxicity of cisplatin and carboplatin was evaluated by Ferk et al [31] they used Salmonella/microsome assay and single-cell gel electrophoresis with rat hepatocytes to assess the induction of DNA damage caused by platinum compounds in hospital sewage. The results revealed that cisplatin and carboplatin only caused significant DNA damage in the single-cell gel electrophoresis assay when the concentration is > 1 mg/L.…”

“…Lenz et al [33] subjected cisplatin and carboplatin in hospital wastewater to a membrane bioreactor system simulating WWTP and achieved 51-63% elimination efficiency. Similarly, membrane filtration method provided a 62-77% reduction in genotoxicity of cisplatin and carboplatin [31].…”

99mTc-Trimethoprim’in Radyosentezi ve Biyodağılımı: Deney Hayvanları Kullanılarak Bakteriyel Enfeksiyon Görüntüleme Için Yeni Bir Radyoişaretli Antibiyotik

“…1 is frequently used as human medicines to treat bronchitis and urinary tract infections. In most circumstance, they are used in combination as chemical therapy agents and growth promoters in veterinary [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] .…”