Genotoxicity of aloeemodin in vitro and in vivo

Heidemann, A.; Völkner, W.; Mengs, U.

doi:10.1016/0165-1218(95)00084-4

Cited by 60 publications

(41 citation statements)

References 13 publications

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“…Several compounds were shown to produce SCE but were negative in the mutation assay. This phenomenon has been reported for other chemical series (25,83) (84); however, for the most part, these tests remain prohibitively expensive (85).…”

Section: Discussionmentioning

confidence: 86%

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Chemical and toxicological characterization of slurry reactor biotreatment of explosives-contaminated soils

Griest¹,

Stewart²,

Vass³

et al. 1998

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Section: Discussionmentioning

confidence: 86%

“…This system is used particularly to identify the types of mutations caused by specific agents (20,21). A wealth of data on the activity of a variety of compounds in this assay is available for comparison (20,(22)(23)(24)(25)(26).…”

Section: The Chinese Hamster Ovary (Cho) Assaymentioning

confidence: 99%

Chemical and toxicological characterization of slurry reactor biotreatment of explosives-contaminated soils

Griest¹,

Stewart²,

Vass³

et al. 1998

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“…1A). The cellular growth was inhibited dose-dependently and IC 50 was observed at 24 h of 37.7 Amol/L. Incubation with 50 Amol/L of emodin for up to 120 h resulted in the growth suppression in a time-dependent manner (Fig.…”

Section: Emodin Inhibits the Cellular Growth And Promotes Apoptosis Imentioning

confidence: 96%

“…Even under condition of a long-term diet of emodin, no evidence of carcinogenic activity in rats and mice was observed (48). In the case of rats or mice given emodin during pregnancy period, neither prenatal mortality nor morphologic development was affected, and genotoxicity of emodin would be unlikely (49,50). Therefore, emodin should be a safe therapeutic agent for MM.…”

Section: Discussionmentioning

confidence: 99%

Emodin has a cytotoxic activity against human multiple myeloma as a Janus-activated kinase 2 inhibitor

Muto

Hori

Sasaki

et al. 2007

Molecular Cancer Therapeutics

118

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Emodin is an active component of a traditional Chinese and Japanese medicine isolated from the root and rhizomes of Rheum palmatum L. Here, we show that emodin significantly induces cytotoxicity in the human myeloma cells through the elimination of myeloid cell leukemia 1 (Mcl-1). Emodin inhibited interleukin-6 -induced activation of Janus-activated kinase 2 (JAK2) and phosphorylation of signal transducer and activator of transcription 3 (STAT3), followed by the decreased expression of Mcl-1. Activation of caspase-3 and caspase-9 was triggered by emodin, but the expression of other antiapoptotic Bcl-2 family members, except Mcl-1, did not change in the presence of emodin. To clarify the importance of Mcl-1 in emodininduced apoptosis, the Mcl-1 expression vector was introduced into the human myeloma cells by electroporation. Induction of apoptosis by emodin was almost abrogated in Mcl-1 -overexpressing myeloma cells as the same level as in parental cells, which were not treated with emodin. In conclusion, emodin inhibits interleukin-6 -induced JAK2/ STAT3 pathway selectively and induces apoptosis in myeloma cells via down-regulation of Mcl-1, which is a good target for treating myeloma. Taken together, our results show emodin as a new potent anticancer agent for the treatment of multiple myeloma patients. [Mol Cancer Ther 2007;6(3):987 -94]

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“…In the latter case, the induced number of mutants should be at least three fold as compared to the negative control (Heidemann et al 1996).…”

Section: Sperm-shape Abnormalitiesmentioning

confidence: 99%

In vivo Genotoxicity Studies of Cefotaxime

Fahmy¹,

Diab²

2009

cytologia

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Summary Cefotaxime is a semisynthetic broad-spectrum bactericidal antibiotic derived from cephalosporin C. The aim of this work is to evaluate the genotoxic effect induced by intraperitoneal (i.p.) administration of cefotaxime at different doses (260, 520 and 1040 mg/kg b.wt.). The induction of sister chromatid exchanges "SCE's" in mouse bone marrow cells, chromosomal aberrations in mouse primary spermatocytes after repeated treatment (4, 7 and 10 d), and morphological sperm abnormalities were determined. The 3 tested doses of cefotaxime induced significant increase in the frequency of sister chromatid exchanges with dose-dependent relationship. A significant increase in the percentage of structural and numerical chromosomal aberrations in mouse spermatocytes was observed after treatment with the doses 520 and 1040 mg/kg b.wt. Cefotaxime also induced different types of head and tail sperm abnormalities. The results showed that cefotaxime has clastogenic and aneugenic effect.

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Genotoxicity of aloeemodin in vitro and in vivo

Cited by 60 publications

References 13 publications

Chemical and toxicological characterization of slurry reactor biotreatment of explosives-contaminated soils

Chemical and toxicological characterization of slurry reactor biotreatment of explosives-contaminated soils

Emodin has a cytotoxic activity against human multiple myeloma as a Janus-activated kinase 2 inhibitor

In vivo Genotoxicity Studies of Cefotaxime

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