Genotoxicity of copper oxide and silver nanoparticles in the mussel Mytilus galloprovincialis

Gomes, Tânia; Araújo, Olinda; Pereira, Rui Pedro Gomes; Almeida, Ana Catarina; Cravo, Alexandra; Bebianno, Maria João

doi:10.1016/j.marenvres.2012.11.009

Cited by 180 publications

(81 citation statements)

References 45 publications

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“…The condition index (CI) was calculated as the percentage (%) of the ratio between drained weight of the soft tissues (g) and total weight (g) according to Gomes et al (2013).…”

Section: Condition Indexmentioning

confidence: 99%

Toxicokinetics and tissue distribution of cadmium-based Quantum Dots in the marine mussel Mytilus galloprovincialis

Rocha

Gomes

Pinheiro

et al. 2015

Environmental Pollution

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“…The condition index (CI) was calculated as the percentage (%) of the ratio between drained weight of the soft tissues (g) and total weight (g) according to Gomes et al (2013).…”

Section: Condition Indexmentioning

confidence: 99%

Toxicokinetics and tissue distribution of cadmium-based Quantum Dots in the marine mussel Mytilus galloprovincialis

Rocha

Gomes

Pinheiro

et al. 2015

Environmental Pollution

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“…Most of the works found in the literature uses high total metal concentrations and in the absence of other critical relevant environmental components (Chandurvelan et al, 2013;Liu and Wang, 2011;Long et al, 2010;Yap et al, 2003). Additionally, and to the best of our knowledge, only five studies with the aim to evaluate the uptake and toxic effects of NPs-only on bivalves are available: pristine nAg (Gomes et al, 2013), nAu (Hull et al, 2011), nCuO (Buffet et al, 2011;Gomes et al, 2013) and Cd-containing quantum dots (Peyrot et al, 2009). The only published work on the effect of NPs on the toxicity of trace metals using bivalves was performed by Balbi et al (Balbi et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Bioavailability of cadmium and biochemical responses on the freshwater bivalve Corbicula fluminea – the role of TiO2 nanoparticles

Vale

Franco

Diniz

et al. 2014

Ecotoxicology and Environmental Safety

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“…[1][2][3][4][5][6][7][8][9][10] Although in the vast nanotoxicological literature of the last decade studies concerned with the assessment of metal or metal-oxide NP toxicity are not at the top of the list, such publications are nevertheless quite numerous. To illustrate this, we may refer to several works devoted to NPs of the metals that were the subject-matter of our own studies considered below: iron oxide, [11][12][13][14][15][16][17][18][19][20] silver, gold, 24,[45][46][47][48][49][50][51][52][53][54][55][56][57][58] copper and copper oxide, 43,[59][60][61][62][63][64][65][66][67][68] nickel oxide, 65,[69]…”

mentioning

confidence: 99%

Some inferences from in vivo experiments with metal and metal oxide nanoparticles: the pulmonary phagocytosis response, subchronic systemic toxicity and genotoxicity, regulatory proposals, searching for bioprotectors (a self-overview)

Katsnelson¹,

Privalova²,

Sutunkova³

et al. 2015

IJN

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The purpose of this paper is to overview and summarize previously published results of our experiments on white rats exposed to either a single intratracheal instillation or repeated intraperitoneal injections of silver, gold, iron oxide, copper oxide, nickel oxide, and manganese oxide nanoparticles (NPs) in stable water suspensions without any chemical additives. Based on these results and some corroborating data of other researchers we maintain that these NPs are much more noxious on both cellular and systemic levels as compared with their 1 μm or even submicron counterparts. However, within the nanometer range the dependence of systemic toxicity on particle size is intricate and non-unique due to complex and often contra-directional relationships between the intrinsic biological aggressiveness of the specific NPs, on the one hand, and complex mechanisms that control their biokinetics, on the other. Our data testify to the high activity of the pulmonary phagocytosis of NPs deposited in airways. This fact suggests that safe levels of exposure to airborne NPs are possible in principle. However, there are no reliable foundations for establishing different permissible exposure levels for particles of different size within the nanometric range. For workroom air, such permissible exposure levels of metallic NP can be proposed at this stage, even if tentatively, based on a sufficiently conservative approach of decreasing approximately tenfold the exposure limits officially established for respective micro-scale industrial aerosols. It was shown that against the background of adequately composed combinations of some bioactive agents (comprising pectin, multivitamin-multimineral preparations, some amino acids, and omega-3 polyunsaturated fatty acid) the systemic toxicity and even genotoxicity of metallic NPs could be markedly attenuated. Therefore we believe that, along with decreasing NP-exposures, enhancing organisms’ resistance to their adverse action with the help of such bioprotectors can prove an efficient auxiliary tool of health risk management in occupations connected with them.

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Genotoxicity of copper oxide and silver nanoparticles in the mussel Mytilus galloprovincialis

Cited by 180 publications

References 45 publications

Toxicokinetics and tissue distribution of cadmium-based Quantum Dots in the marine mussel Mytilus galloprovincialis

Toxicokinetics and tissue distribution of cadmium-based Quantum Dots in the marine mussel Mytilus galloprovincialis

Bioavailability of cadmium and biochemical responses on the freshwater bivalve Corbicula fluminea – the role of TiO2 nanoparticles

Some inferences from in vivo experiments with metal and metal oxide nanoparticles: the pulmonary phagocytosis response, subchronic systemic toxicity and genotoxicity, regulatory proposals, searching for bioprotectors (a self-overview)

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