Genotoxicity of engineered nanomaterials: A critical review

Gonzalez, Laetitia; Lison, Dominique; Kirsch‐Volders, Micheline

doi:10.1080/17435390802464986

Cited by 227 publications

(146 citation statements)

References 90 publications

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“…It is already known that nanomaterials induce genotoxicity for 2 main reasons: ROS generation, which is caused by the high atom-to-surface ratio, and mechanical interference with cellular components, such as the nucleosome, microtubules, actin filament, and centrosome. 46,51,53 The ROS are also known to be involved in diverse physiological processes, including cell growth and differentiation, senescence, and cell death in various cell types, including prokaryotic and eukaryotic cells. 54 Plus, ROS give rise to various genotoxicities, including DNA damage, gene mutation, MN formation, and chromosome aberrations.…”

Section: Discussionmentioning

confidence: 99%

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Multiwall Carbon Nanotube-Induced DNA Damage and Cytotoxicity in Male Human Peripheral Blood Lymphocytes

Kim

Song

2015

Int J Toxicol

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Carbon nanotubes (CNTs) have been introduced recently as a novel carrier system for both small and large therapeutic molecules. Biotin-functionalized single-wall CNTs have been conjugated with the anticancer agent taxoid using a cleavable linker, and multiwall carbon nanotubes (MWCNTs) conjugated with iron nanoparticles have been efficiently loaded with doxorubicin. 1,2The MWCNTs are effective transporters for biological macromolecules and drugs to target cells and tissues, thereby attracting the attention of the biomedical industry.3-7 Administrating MWCNTs for medical application invariably involves intravenous administration and ultimate contact with human peripheral blood lymphocytes (HPBLs), yet toxicological studies on the effect of MWCNTs on HPBLs are lacking. Accordingly, this study evaluated the cytotoxic and genotoxic effects of MWCNTs on healthy male HPBLs. Healthy male HPBLs were treated with MWCNTs at 3 different concentrations (12.5, 25, and 50 mg/mL) for 48 hours. Under these conditions, the MWCNTs induced significant cell growth retardation, DNA damage, and cytotoxicity. The MWCNT-treated HPBLs also exhibited an increased intracellular reactive oxygen species level during the experimental period, which leads to cell damage and death, proliferation inhibition, DNA damage, and an inflammatory response.

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Section: Discussionmentioning

confidence: 99%

“…51 Therefore, the genotoxic effect of MWCNT treatment was investigated using a comet assay and MN assay. Until now, no genotoxicity studies have investigated the impact of MWCNT treatment on normal HPBLs, although SWCNTs are known to induce genotoxicity in HPBLs.…”

Section: Discussionmentioning

confidence: 99%

Multiwall Carbon Nanotube-Induced DNA Damage and Cytotoxicity in Male Human Peripheral Blood Lymphocytes

Kim

Song

2015

Int J Toxicol

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“…Some researchers have examined the effects of free radicals on ENP genotoxicity [93], whereas others have discussed the impact of ion shedding on cytotoxicity [60,94,95].…”

Section: Between Each Factor (Level-3 Classifi Cation)mentioning

confidence: 99%

A pilot study towards ranking occupational health risk factors emanating from engineered nanoparticles: review of a decade of literature

Fatisson¹,

Nadeau²,

Hallé³

et al. 2013

Int. J. SAFE

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As benefi cial applications of nanotechnologies in industry and medicine continue to emerge, so do new problems associated with engineered nanoparticle (ENP) production, which so far is going ahead without prior evaluation of its impact on human health and environment. Worker exposure continues to increase while no global consensus on ENP regulation has been reached. Protection of workers requires an approach to risk management properly adapted to the ENP context. Although ENP properties have been studied in depth over the past 10 years, much uncertainty continues to loom over the defi nition of the key parameters. The aim of this review of the literature was to construct a detailed list of known risks associated with ENPs from an occupational health and safety perspective. A hierarchised network of risks was thus revealed, illustrating the complexity of the system in terms of interdependence of elements of risk.

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“…Engineered nanoparticles are known to posses major genotoxic effects such as interaction with DNA and non DNA targets, their interaction with components associated with cell growth cycle such as centromeres, cytoskeleton, microtubules etc induce polyploidy and aneugenic events during cell division. Some of the other possible effects of nanoparticles include Metal release, desorption of organic components, interaction with SH groups and Zn fingers of key proteins, saturation of metallothionein, changes in DNA methylation, secondary genotoxic effects through inflammation and activation of leukocytes, HIF stabilization through hypoxia-like effects, apoptosis/ necrosis and inhibition of key receptors/enzymes [49]. Although, various above discussed limitations and unforeseen problems that can arise from nanotechnology and its applications in medicine, its derivative technologies have a promising impact to solve more problems than they will create.…”

Section: Limitations Of Nanotechnologymentioning

confidence: 99%

Applications of Nanomedicine in Antibacterial Medical Therapeutics and Diagnostics~!2009-08-26~!2009-11-25~!2010-02-24~!

Matthews¹,

Kanwar²,

Zhou³

et al. 2010

TOTMJ

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Abstract:The need for new and effective/efficient antibacterial therapeutics and diagnostics is necessary if we want to be able to maintain and improve the protection against pathogenic bacteria. Bacteria are becoming increasingly resistant to traditionally used antibiotics and as a result are a major health concern. The number of deaths and hospitalizations due to bacteria is increasing. Current methods of bacterial diagnostics are inefficient as they lack speed and ultra sensitivity and cannot be performed on site. This is where nanomedicine is playing a vital role. The discovery of new and innovative materials through the improvement in fabrication techniques has seen the establishment of an influx of novel antibacterial therapeutics and diagnostics. The goal of this review is to highlight the research that has been done through the implementation of nanomaterials and nanotechnologies for antibacterial medical therapeutic and diagnostic.

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Genotoxicity of engineered nanomaterials: A critical review

Cited by 227 publications

References 90 publications

Multiwall Carbon Nanotube-Induced DNA Damage and Cytotoxicity in Male Human Peripheral Blood Lymphocytes

Multiwall Carbon Nanotube-Induced DNA Damage and Cytotoxicity in Male Human Peripheral Blood Lymphocytes

A pilot study towards ranking occupational health risk factors emanating from engineered nanoparticles: review of a decade of literature

Applications of Nanomedicine in Antibacterial Medical Therapeutics and Diagnostics~!2009-08-26~!2009-11-25~!2010-02-24~!

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