Genotype-specific prevalence and distribution of human papillomavirus genotypes in underserved Latino women with abnormal Papanicolaou tests

Zhou, Haijun; Mody, Dina R.; Schwartz, Mary R.; Coffey, Donna; Smith, Daniel H.; Zwain, Omar; Kamarapu, Naga P.; Brown, J.; Medina, Marcela; Hodgson, Sonia R.; Hobday, Christopher; Ge, Yimin

doi:10.1016/j.jasc.2013.06.001

Cited by 6 publications

(8 citation statements)

References 31 publications

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“…Despite the observed trends in our present investigation, our results need to be interpreted cautiously as the study cohort is a high-risk population with a high HPV infection rate and it exhibits a different genotypic pattern from the general screening population in the United States [39]. In this respect, the findings from this study may not be applicable to other populations.…”

Section: Discussioncontrasting

confidence: 74%

Multiple Human Papilloma Virus Infections and Their Impact on the Development of High-Risk Cervical Lesions

et al. 2015

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Objective: Individuals are often infected with multiple genotypes of human papillomavirus (HPV) simultaneously, but the role these infections play in the development of cervical disease is not well established. This study aimed to determine the association of multiple HPV infections with high-risk cervical lesions (hrCLs). Study Design: HPV genotyping was performed on 798 SurePath specimens collected between December 1, 2009, and April 30, 2011. The cases were classified as hrCL (n = 90) or non-hrCL (n = 708) based on cytology diagnoses. The association between hrCL and HPV infection patterns was analyzed. Results: Multiple HPV infections were frequently encountered (38.2%) in the cohort. Increased frequency of hrCLs was associated with a single high-risk HPV (hrHPV) infection. An additive or synergistic effect was not observed for hrCL in multiple HPV infections. The hrCL rates appeared to decrease in various patterns of multiple HPV infections, but the reduction was not statistically significant. Conclusions: Multiple HPV infections are common with no additive or synergistic effect on the development of hrCL. Conversely, reduced hrCL rates were observed in various patterns of multiple HPV infections compared to their single-genotype infection counterparts, suggestive of possible intergenotypic competition or more effective immune response triggered by multiple infections. Further studies in larger cohorts are needed.

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Section: Discussioncontrasting

confidence: 74%

Multiple Human Papilloma Virus Infections and Their Impact on the Development of High-Risk Cervical Lesions

et al. 2015

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“…For example, the ATHENA study was based on a population representative of the general cervical cancer screening population in the United States, with more than 80% Caucasian and only 19.1% Hispanic. We previously demonstrated a very different genotypic HPV composition in our patient population versus the general population in North America . In combination, these factors may significantly alter the composition of the infectious agents that we detected as well as the interaction between HPV genotypes and the pattern of disease progression.…”

Section: Discussionmentioning

confidence: 78%

“…We previously demonstrated a very different genotypic HPV composition in our patient population versus the general population in North America. 19,20 In combination, these factors may significantly alter the composition of the infectious agents that we detected as well as the interaction between HPV genotypes and the pattern of disease progression. By analyzing the distribution of HPV genotypes in patients with LSIL cytology around the world, Clifford et al 21 demonstrated that women from Africa were significantly less likely to be infected with HPV-16 than women in Europe, whereas women in North America, Central America, and South America were more likely to have an intermediate risk of HPV-16 infection.…”

Section: Discussionmentioning

confidence: 99%

“…By analyzing the distribution of HPV genotypes in patients with LSIL cytology around the world, Clifford et al demonstrated that women from Africa were significantly less likely to be infected with HPV‐16 than women in Europe, whereas women in North America, Central America, and South America were more likely to have an intermediate risk of HPV‐16 infection. As the Hispanic population grows in the United States, the current pattern of HPV infections may change accordingly . Therefore, the implications of HPV‐16/18 genotyping addressed in this study should not be universally applied to all populations because we believe that the data need to be interpreted within the context of a specific population and ethnicity.…”

Section: Discussionmentioning

confidence: 99%

“…As the Hispanic population grows in the United States, the current pattern of HPV infections may change accordingly. 20 Therefore, the implications of HPV-16/18 genotyping addressed in this study should not be universally applied to all populations because we believe that the data need to be interpreted within the context of a specific population and ethnicity. Hence, further investigation is warranted to elucidate the population-specific predictive value for high-grade cervical lesions and cancer.…”

Section: Discussionmentioning

confidence: 99%

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Non‐16/18 high‐risk HPV infection predicts disease persistence and progression in women with an initial interpretation of LSIL

Lyons

Kamat

Zhou

et al. 2015

Cancer Cytopathology

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BACKGROUND:The current management strategy for women with low-grade squamous intraepithelial lesions (LSILs) is inefficient and expensive because of the inability to identify patients at high risk for disease progression. KEY WORDS: human papillomavirus (HPV); human papillomavirus genotyping; low-grade squamous intraepithelial lesion; non-16/18 high-risk human papillomavirus genotypes; persistent cervical dysplasia; progression of cervical disease.

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Human papillomavirus genotyping among women with cervical abnormalities in Ulaanbaatar, Mongolia

Tsedenbal

Yoshida

Enkhbat

et al. 2018

International Journal of Infectious Diseases

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Few studies on human papillomavirus (HPV) have been conducted in Mongolia. This study was performed to evaluate the prevalent HPV genotypes and their associations with cytology and demographic and behavioral characteristics in Mongolian women with cervical abnormalities. Methods: Exfoliated cell samples of 100 women who had a previous history of cervical abnormality were collected. Cytological interpretation was conducted microscopically and HPV genotyping was performed using the Roche Linear Array test. Study questionnaires were completed. Results: Overall, 25 HPV genotypes were detected in 47% of participants, and the most prevalent were HPV 16, 52, 58, and 33. Cytological examination revealed 12% of participants had atypical squamous cells of undetermined significance (ASC-US), 8% had low-grade squamous intraepithelial lesions (LSIL), 7% had high-grade squamous intraepithelial lesions (HSIL), and 14% had squamous cell carcinoma (SCC), while 59% of women had a normal cytology. HPV 16 was the most common type among women with a normal cytology and cervical cancer. However, women with cervical abnormalities including LSIL and HSIL were predominantly infected with HPV 52. Moreover, women aged <35 years had a significantly higher risk of HPV infection than those in the other age groups (p < 0.05). Conclusions: The prevalent trend of HPV genotypes observed in this cohort differs from that reported previously in Mongolia. These data may contribute to developing an effective strategy for cervical cancer prevention in Mongolia.

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Genotype-specific prevalence and distribution of human papillomavirus genotypes in underserved Latino women with abnormal Papanicolaou tests

Cited by 6 publications

References 31 publications

Multiple Human Papilloma Virus Infections and Their Impact on the Development of High-Risk Cervical Lesions

Multiple Human Papilloma Virus Infections and Their Impact on the Development of High-Risk Cervical Lesions

Non‐16/18 high‐risk HPV infection predicts disease persistence and progression in women with an initial interpretation of LSIL

Human papillomavirus genotyping among women with cervical abnormalities in Ulaanbaatar, Mongolia

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