Genotyping of Mumps Virus Strains Detected in Kobe City from 1991 to 2012

Akiyoshi, Kyoko; Suga, Tomoko

doi:10.7883/yoken.67.323

Cited by 5 publications

(3 citation statements)

References 11 publications

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“…Cluster 1 composed of MuVs circulated in countries from Europe (Belarus, Israel, Italy, Spain, Sweden, Switzerland, Turkey and UK) ( Akcali et al, 2009 ; Atrasheuskaya et al, 2007 ; Hindiyeh et al, 2009 ; Montes et al, 2002 ; Utz et al, 2004 ) and America (the USA, Dominican Republic-JQ034432,), while cluster 2 was composed of MuVs from Asia (Mongolia, South Korea, the Philippine, and Japan).The MuVs of genotype H that cause outbreaks in South Korea in 1999 (sub cluster KOR 99) ( Lee et al, 2003 ) could be differentiated from MuVs circulated in 2008–2012 (sub cluster KOR 08–12) and the other outbreak strains of Mongolia in 2009 (sub cluster MNG 09) ( Kidokoro et al, 2011 ). The imported MuVs from the Philippines as indicated in Taiwan and Canada (JQ783112,JQ809709), MuVs from Kobe City, Japan (sub cluster JPN 10) ( Akiyoshi and Suga, 2014 ), and MuVs circulated in South Korea in 2008–2012 (sub cluster KOR 08–12) composed of sub cluster Asia 04–12.While strains MuVs/BritishColumbia.CAN/01.12(JQ783116) had been indicated as imported from South Africa, similar sequences deposited in GenBank including MuVi/Morelex.MEX/12.13, MuVs/Stockholm.SWE/36.14, MuVs/Minnesota.USA/16.14, MuVs/California.USA/19.14, MuVs/California.USA/36.15 formed sub cluster America 12–15 implied the continuing transmission. Another strain (MuVs/Calgary.CAN/30.07.…”

Section: Resultsmentioning

confidence: 99%

Molecular characteristics of mumps viruses isolated in Taiwan from 2006 to 2016

Cheng

Liu

2018

Heliyon

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Sixteen mumps virus (MuV) sequences collected in Taiwan between 2006 and 2016 were characterized as genotype F (n = 1), G (n = 7), H (n = 4), J (n = 2), and K (n = 2). Mumps genotype F strain was imported from China in 2008 which was in accordance with the epidemic genotype in China. The Philippines was indicated as export country of three genotype H strains in 2007–2010 and Vietnam as export country of one genotype K strain in 2016 that matched with genotypes described in previous reports. Four strains of genotype G were imported from Japan, Thailand, Malaysia and Myanmar individually indicated that genotype G spreads widely in Asia as well as in the global. In this study, mumps strains of genotype G was first reported in relation to import from Malaysia and Myanmar. Furthermore, Indonesia was referred to export MuV of genotype J in 2007 for the first time. Molecular genotyping benefits the differentiation of circulating mumps viruses and can be used to investigate the transmission pathways. The dynamic genotypes of imported cases revealed the epidemic genotypes in nearby countries.

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Section: Resultsmentioning

confidence: 99%

Molecular characteristics of mumps viruses isolated in Taiwan from 2006 to 2016

Cheng

Liu

2018

Heliyon

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“…Genotype G was the most frequently isolated genotype in our study (900 isolates out of 1,064 isolates, 84.6%) as it was predominant in the last two decades in Japan, and our surveillance network began to work at full scale during this period. Although previous studies have reported that the Japanese genotype G consists of two major clades (Akiyoshi and Suga, 2014;Aoki et al, 2016;Kuba et al, 2017), we identified at least seven clades in this study using SH-based classification on the basis of the topology of the phylogenetic tree, designated Csh-1, -2, -3, -4, -5, -6, and -7 (Figure 6). However, as most bootstrap values of each clade were <75%, the topology of the phylogenetic tree could be inaccurate.…”

Section: Specimen Descriptionsmentioning

confidence: 99%

“…Earlier molecular epidemiology studies of Japanese MuVs showed that genotype B was the dominant indigenous genotype until the 1980s, and genotypes B and J subsequently co-circulated in the 1990s. Genotype G emerged at the end of the 1990s, and since 2000, it has been circulating predominantly in Japan ( Inou et al, 2004 ; Akiyoshi and Suga, 2014 ; Aoki et al, 2016 ), which contains at least 2 subgenotypes ( Inou et al, 2004 ; Kidokoro, 2013 ; Aoki et al, 2016 ; Kuba et al, 2017 ). However, in the previous studies have limitations in the research areas owing to research at the municipal level and length of the data collection period.…”

Section: Introductionmentioning

confidence: 99%

Nationwide and long-term molecular epidemiologic studies of mumps viruses that circulated in Japan between 1986 and 2017

Kidokoro¹,

Shiino²,

Yamaguchi³

et al. 2022

Front. Microbiol.

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In Japan, major mumps outbreaks still occur every 4–5 years because of low mumps vaccine coverage (30–40%) owing to the voluntary immunization program. Herein, to prepare for a regular immunization program, we aimed to reveal the nationwide and long-term molecular epidemiological trends of the mumps virus (MuV) in Japan. Additionally, we performed whole-genome sequencing (WGS) using next-generation sequencing to assess results from conventional genotyping using MuV sequences of the small-hydrophobic (SH) gene. We analyzed 1,064 SH gene sequences from mumps clinical samples and MuV isolates collected from 25 prefectures from 1986 to 2017. The results showed that six genotypes, namely B (110), F (1), G (900), H (3), J (41), and L (9) were identified, and the dominant genotypes changed every decade in Japan since the 1980s. Genotype G has been exclusively circulating since the early 2000s. Seven clades were identified for genotype G using SH sequence-based classification. To verify the results, we performed WGS on 77 representative isolates of genotype G using NGS and phylogenetically analyzed them. Five clades were identified with high bootstrap values and designated as Japanese clade (JPC)-1, -2, -3, -4, -5. JPC-1 and -3 accounted for over 80% of the total genotype G isolates (68.3 and 13.8%, respectively). Of these, JPC-2 and -5, were newly identified clades in Japan through this study. This is the first report describing the nationwide and long-term molecular epidemiology of MuV in Japan. The results provide information about Japanese domestic genotypes, which is essential for evaluating the mumps elimination progress in Japan after the forthcoming introduction of the mumps vaccine into Japan’s regular immunization program. Furthermore, the study shows that WGS analysis using NGS is more accurate than results obtained from conventional SH sequence-based classification and is a powerful tool for accurate molecular epidemiology studies.

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