This study investigated the land use and land cover changes in the state of São Paulo, Brazil, for the period of 2002 through 2017, to determine if forested areas were burned or converted to other land uses, to analyze the use of fire as a catalyst and mechanism for land cover change, and to determine if there was a relationship between land use changes and gross domestic product (GDP). MapBiomas classifications and MODIS data were analyzed using the Google Earth Engine. The results of the analysis found that there were minimal changes in the forested areas in São Paulo during the study period; however, there was a 5% increase in natural forest and a 75% increase in planted forest cover. On the other hand, there was a 128% increase in sugarcane, and nearly a 50% decrease in pasture land coverage, suggesting that land was converted from pasture to more profitable agricultural land. Finally, there was a strong positive correlation (r = 0.96) between the increase in sugarcane and the GDP, and a negative correlation between the frequency of fire events and economic production (r = −0.62). Overall, there was a decline in fire events in São Paulo, with fire events occurring in less than 2% of the total observed land area by 2017. This overall declining trend in fire events are likely the direct result of increases in green harvest methods, which prevent the need for pre-harvest burning.