Geographic Variation and Risk of Skin Cancer in US Women&lt;subtitle&gt;Differences Between Melanoma, Squamous Cell Carcinoma, and Basal Cell Carcinoma&lt;/subtitle&gt;

Qureshi, Abrar A.

doi:10.1001/archinte.168.5.501

Cited by 81 publications

(80 citation statements)

References 58 publications

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“…Despite the progresses in chemotherapy, surgery, and radiotherapy to limit the mortality it causes, the situation is still not optimistic because melanoma incidence has doubled since 1950s in Europe, Singapore, Canada, and United State [2][3][4]. Consequently, the further research of melanoma, such as the mechanisms underlying its pathogenesis, is important to identify its occurrence and metastasis early and provide new potential targets for melanoma treatment.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-29a Inhibits Growth, Migration and Invasion of Melanoma A375 Cells in Vitro by Directly Targeting BMI1

Xiong

Liu

Qiu

et al. 2018

Cell Physiol Biochem

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Background/Aims: Melanoma is one of the most aggressive malignant tumors, with increasing incidence, poor prognosis, and lack of any effective targeted therapies. Abnormal expression of miR-29a has been found in several types of cancers, including melanoma. In this study, experiments were performed to investigate the role of miR-29a in melanoma, and the molecular mechanism by which miR-29a represses melanoma. Methods: miR-29 and Bmi1 expression was examined by quantitative real-time polymerase chain reaction (qRT-PCR). The cell viability, apoptosis, migration and invasion were respectively determined by Cell Counting Kit-8 assay, Propidium iodide (PI) fluorescein isothiocynate (FITC)-Annexin V staining assay, wound healing assay and transwell assay. Luciferase reporter assay was performed to determine a target gene of miR-29a. Western blot was used to analyze protein expression of apoptosis-related proteins, Bmi1, Wnt/β-catenin and Nuclear factor-κB (NF-κB) pathway target genes. Results: miR-29a was down-regulated in all tested melanoma cell lines. Up-regulation of miR-29a effectively inhibited cell viability, migration, and invasion, but promoted apoptosis in A375 cells. Bmi1 was a direct target gene of miR-29a. Transfection with miR-29a mimic decreased cell migration and invasion and Bmi1 expression in Malme-3M cells, SK-MEL-2, SK-MEL-5, and M14 cell lines. Moreover, miR-29a might suppress growth, migration and invasion of A375 cells by negatively regulating Bmi1. In addition, our results demonstrated that transfection with miR-29a mimic effectively blocked Wnt/β-catenin and NF-κB pathways via down-regulating Bmi1. Conclusion: miR-29a could be functioned as a potential tumor suppressor through direct regulation of Bmi1 in melanoma cells.

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Section: Introductionmentioning

confidence: 99%

MicroRNA-29a Inhibits Growth, Migration and Invasion of Melanoma A375 Cells in Vitro by Directly Targeting BMI1

Xiong

Liu

Qiu

et al. 2018

Cell Physiol Biochem

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“…The increased melanin barrier in darker-pigmented individuals decreases both ultraviolet (UV) A and B radiation through the skin (38)(39)(40). UV radiation is known to induce both cell death and malignant transformation of skin cells; it is considered the paramount risk factor for melanoma (41)(42)(43)(44)(45)(46). Compared to fairer-skinned people, UVB radiation through the epidermis is diminished by approximately 50% in darker-skinned people (38), and UVA transmission through the dermis decreases from 27 to 4% at 314 nm and 47 to 14% at 400 nm (39).…”

Section: Ethnicitymentioning

confidence: 99%

Epidemiology of Melanoma

Matthews

Qureshi

et al. 2017

Cutaneous Melanoma: Etiology and Therapy

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Melanoma is a potentially lethal cancer that is most commonly cutaneous. The worldwide incidence of melanoma has risen rapidly over the course of the last 50 years. Its incidence is greatest among fair-skinned populations, and in regions of lower latitude. Incidence is greater among geriatric populations, but melanoma is also among the most common cancers found in adolescent and young adult populations. In fact, it is one of the leading cancers in average years of life lost per death from disease. Melanoma incidence varies by sex, which is also associated with differences in melanoma anatomic site. Similar differences by region, ethnicity, age, and sex are observed in mortality rates of melanoma. In the setting of rising incidence and mortality, melanoma bears a heavy health and economic burden. Attributable costs are several billion in nations with greater melanoma incidence. Preventative strategies have been implemented in multiple high-risk regions with variable success. It is imperative that research efforts Epidemiology of Melanoma 4 achieve better understanding of the risk factors and etiology of disease, with the goal to halt and reverse the progressive trend of rising incidence and mortality from melanoma.

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“…In sheep, the tumor occurs most frequently on the muzzle, lips, eyelids, pinnae, perineum and vulva (MAULDIN & KENNEDY, 2016;MACEDO et al, 2008). While SCC in animals and humans is global in occurrence, differences in its distribution in various areas of García et al the world have been observed (NEWTON, 1996;BRONDEN et al, 2007;QURESHI et al, 2008). The incidence rate of SCC varies geographically, and is highest in the southern hemisphere and with decreasing latitude, i.e.…”

Section: Introductionmentioning

confidence: 99%

Occurrence of squamous cell carcinoma in Milchschaf sheep in Uruguay

García

Quinteros²,

Romero³

et al. 2017

Cienc. Rural

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In this study, the epidemiological and pathological features of an outbreak of squamous cell carcinoma (SCC) in adult female sheep and a young ram, Friesian Milchschaf breed or crossbreed is described. Seven adult females belonging to an original flock nucleus of 20 animals were affected, as well as a young ram belonging to the same nucleus was affected in other establishment. Multiple verrucous neoplastic masses of several months of evolution were evident in the head region, with local invasion and regional lymph node metastases. Histological studies revealed a cancerous stage of invasion of the dermis and neoplastic proliferation characteristic of invasive SCC, and a pre-cancerous stage with solar elastosis and chronic solar keratosis lesions induced by sunlight. Decrease in latitude, increased level of solar radiation with long exposure to sunlight, and the phenotypic characteristics of the breed are the main factors responsible for the high prevalence of SCC, showing the susceptibility of the Friesian Milchschaf breed and crossbreed in temperate zones as Uruguay.

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Geographic Variation and Risk of Skin Cancer in US Women<subtitle>Differences Between Melanoma, Squamous Cell Carcinoma, and Basal Cell Carcinoma</subtitle>

Cited by 81 publications

References 58 publications

MicroRNA-29a Inhibits Growth, Migration and Invasion of Melanoma A375 Cells in Vitro by Directly Targeting BMI1

MicroRNA-29a Inhibits Growth, Migration and Invasion of Melanoma A375 Cells in Vitro by Directly Targeting BMI1

Epidemiology of Melanoma

Occurrence of squamous cell carcinoma in Milchschaf sheep in Uruguay

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