Melanoma is a potentially lethal cancer that is most commonly cutaneous. The worldwide incidence of melanoma has risen rapidly over the course of the last 50 years. Its incidence is greatest among fair-skinned populations, and in regions of lower latitude. Incidence is greater among geriatric populations, but melanoma is also among the most common cancers found in adolescent and young adult populations. In fact, it is one of the leading cancers in average years of life lost per death from disease. Melanoma incidence varies by sex, which is also associated with differences in melanoma anatomic site. Similar differences by region, ethnicity, age, and sex are observed in mortality rates of melanoma. In the setting of rising incidence and mortality, melanoma bears a heavy health and economic burden. Attributable costs are several billion in nations with greater melanoma incidence. Preventative strategies have been implemented in multiple high-risk regions with variable success. It is imperative that research efforts Epidemiology of Melanoma 4 achieve better understanding of the risk factors and etiology of disease, with the goal to halt and reverse the progressive trend of rising incidence and mortality from melanoma.

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Connolly, L. (2017). The endocrine disrupting potential of monosodium glutamate (MSG) on secretion of the glucagon-like-peptide-1 (GLP-1) gut hormone and GLP-1 receptor interaction. Toxicology Letters, 265, 97-105. DOI: 10.1016/j.toxlet.2016 Published in: Toxicology Letters Document Version: Peer reviewed version Queen's University Belfast -Research Portal: Link to publication record in Queen's University Belfast Research Portal Publisher rights © 2016 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/bync-nd/4.0/ which permits distribution and reproduction for non-commercial purposes, provided the author and source are cited. General rightsCopyright for the publications made accessible via the Queen's University Belfast Research Portal is retained by the author(s) and / or other copyright owners and it is a condition of accessing these publications that users recognise and abide by the legal requirements associated with these rights.Take down policy The Research Portal is Queen's institutional repository that provides access to Queen's research output. Every effort has been made to ensure that content in the Research Portal does not infringe any person's rights, or applicable UK laws. If you discover content in the Research Portal that you believe breaches copyright or violates any law, please contact openaccess@qub.ac.uk. fold; P<0.001), however, 72 h exposure (500 μg/ml) caused a 1.8 fold decline (P<0.05). 32Also,3 h MSG exposure (0.5-500 μg/ml) did not induce any cytotoxicity (including multiple 33 pre-lethal markers) but 72 h exposure at 250-500 μg/ml, decreased cell number (11.8-26.7%;