The endocrine disrupting potential of monosodium glutamate (MSG) on secretion of the glucagon-like peptide-1 (GLP-1) gut hormone and GLP-1 receptor interaction

Abstract

Connolly, L. (2017). The endocrine disrupting potential of monosodium glutamate (MSG) on secretion of the glucagon-like-peptide-1 (GLP-1) gut hormone and GLP-1 receptor interaction. Toxicology Letters, 265, 97-105. DOI: 10.1016/j.toxlet.2016 Published in: Toxicology Letters Document Version: Peer reviewed version Queen's University Belfast -Research Portal: Link to publication record in Queen's University Belfast Research Portal Publisher rights © 2016 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/bync-nd/4.0/ which permits distribution and reproduction for non-commercial purposes, provided the author and source are cited. General rightsCopyright for the publications made accessible via the Queen's University Belfast Research Portal is retained by the author(s) and / or other copyright owners and it is a condition of accessing these publications that users recognise and abide by the legal requirements associated with these rights.Take down policy The Research Portal is Queen's institutional repository that provides access to Queen's research output. Every effort has been made to ensure that content in the Research Portal does not infringe any person's rights, or applicable UK laws. If you discover content in the Research Portal that you believe breaches copyright or violates any law, please contact openaccess@qub.ac.uk. fold; P<0.001), however, 72 h exposure (500 μg/ml) caused a 1.8 fold decline (P<0.05). 32Also,3 h MSG exposure (0.5-500 μg/ml) did not induce any cytotoxicity (including multiple 33 pre-lethal markers) but 72 h exposure at 250-500 μg/ml, decreased cell number (11.8-26.7%;

The genetic basis of high-carbohydrate and high-monosodium glutamate diet related to the increase of likelihood of type 2 diabetes mellitus: a review

“…MSG was found to impair glucagon-like peptide (GLP-1) secretion in cell model, a peptide hormone that is important for β-cell growth, and insulin production [54]. In short term (3 h), secretion of GLP-1 was increased, but in chronic term (72 h), cytotoxicity was observed and there was a reduction in GLP-1 secretion [55].…”

The brain-gut-microbiome axis modulation of food intake in health and in obesity: Links beyond the 16S rRNA

“…Elevated glutamate levels are associated with obesity and the administration of Bacteroides thetaiotaomicron, a glutamate fermenting bacteria, prevented weight gain in a DIO mouse model, underscoring a link between diet, GM, amino acids profiles, and weight regulation 55 . In addition, glutamate has shown to decrease production of GLP-1 by enteric L cells 56 .…”

In vitro bioassay investigations of suspected obesogen monosodium glutamate at the level of nuclear receptor binding and steroidogenesis

“…We have previously shown that MSG decreases glucagon-like peptide 1 (GLP-1) secretion in a gut in vitro cellular model (Shannon et al, 2017), suggesting a possible mechanism by which MSG may affect glucose regulation and satiety responses.…”