We present a neotectonic model of ongoing lithosphere deformation and a corresponding estimate of long-term shallow seismicity across the Africa-Eurasia plate boundary, including the eastern Atlantic, Mediterranean region, and continental Europe. GPS and stress data are absent or inadequate for the part of the study area covered by water. Thus, we opt for a dynamic model based on the stress equilibrium equation; this approach allows us to estimate the long-term behavior of the lithosphere (given certain assumptions about its structure and physics) for both land and sea areas. We first update the existing plate model by adding five quasirigid plates (the Ionian Sea, Adria, Northern Greece, Central Greece, and Marmara) to constrain the deformation pattern of the study area. We use the most recent data sets to estimate the lithospheric structure. The models are evaluated in comparison with updated data sets of geodetic velocities and the most compressive horizontal principal stress azimuths. We find that the side and basal strengths drive the present-day motion of the Adria and Aegean Sea plates, whereas lithostatic pressure plays a key role in driving Anatolia. These findings provide new insights into the neotectonics of the greater Mediterranean region. Finally, the preferred model is used to estimate long-term shallow seismicity, which we retrospectively test against historical seismicity. As an alternative to reliance on incomplete geologic data or historical seismic catalogs, these neotectonic models help to forecast long-term seismicity, although requiring additional tuning before seismicity rates are used for seismic hazard purposes.