Geriatric Telepsychiatry in Academic Settings

Srinivasan, Shilpa; Jones, Ashley Blackmon; Hilty, Donald M.

doi:10.1007/978-3-319-51491-8_4

Cited by 3 publications

(1 citation statement)

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“…Many theories were proposed as risk factors for schizophrenia, starting from developmental processes, neurodegenerative, and neurotransmitter disorders to the occurrence of infectious or autoimmune processes [2]. Growth factors and other cytokines have been linked to the pathology or genesis of schizophrenia, and it has been found that the central nervous system contains and utilizes their receptors (CNS).…”

Section: Introductionmentioning

confidence: 99%

Candidate IL-1β -511C/T Polymorphism in Schizophrenia Patients in Batak Tribe

Nasution¹,

Effendy²,

Amin³

2023

Advances in Health Sciences Research

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Background: There are approximately 20 million cases of schizophrenia worldwide. This complication can result from developmental processes, neurodegenerative, and neurotransmitter disorders to the occurrence of infectious or autoimmune processes. Furthermore, serotonin, noradrenaline, dopamine, and glutamate are just a few of the neurotransmitters that cytokines may play a role in controlling. The relationships between glutamate and dopamine seem to be important for understanding the pathophysiology of schizophrenia. According to cellular receptors and the intracellular environment, which serve as risk factors for schizophrenia, IL-1 is involved in neurodevelopmental processes and can have neurotoxic or neuroprotective effects.Method: Non-probability purposive sampling was conducted on 240 subjects (120 people with schizophrenia (ODS) and 120 healthy control of Batak tribe) hospitalized at Prof. M. ILDREM Medan, Indonesia, as normal control and East Medan Sub-district as healthy control. In addition, the IL-1β -511 C/T Polymorphism was analyzed using RFLP and PCR methods.Result: The -511Allele frequency of the IL-β -511 C/T (rs16944) polymorphism was different between cases and controls with a p-value of 0.001 and OR of 1.901 and a 95% confidence interval between 1.322 to 2.735. The p-value for the genotype (CC vs. TT) was 0.019 with an OR of 0.414 and a 95% CI between 0.198-0.866. Meanwhile, the p-value for the genotype (CT vs TT) was 0.388 with an OR of 0.746 and a 95% CI between 0.384-1.451. Conclusion:The results showed that the IL-1β -511 C/T polymorphism has a relationship with the incidence of schizophrenia, and may be a risk factor for schizophrenia in Batak people.

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Section: Introductionmentioning

confidence: 99%