German register for glaucoma patients with dry eye. I. Basic outcome with respect to dry eye

Erb, Carl; Gast, Ulrike; Schremmer, D.

doi:10.1007/s00417-008-0881-9

Cited by 147 publications

(124 citation statements)

References 32 publications

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“…Previous studies are showing a strong correlation between the number of IOP-lowering medications used and the presence of dry eye [8,16,17]. Study by Rossi et al [16] described the prevalence of OSD and they wanted to assess quality of life in subjects with glaucoma.…”

Section: Discussionmentioning

confidence: 99%

“…Patients were grouped into 4 categories by OSDI score: normal (scores 0-12), mild OSD symptoms (13)(14)(15)(16)(17)(18)(19)(20)(21)(22), moderate OSD symptoms (23-32), severe OSD symptoms (33-100) [13]. Patients' medical records were used to obtain medical history including detailed data on the use of medication and duration of therapy.…”

Section: Clinical and Experimental Ophthalmologymentioning

confidence: 99%

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Prevalence of Ocular Surface Disease in Patients with Glaucoma using Topical Antiglaucoma Medications

Barišić¹

2014

J Clin Exp Ophthalmol

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Purpose: To establish the prevalence of ocular surface disease (OSD) in glaucoma patients using topical intraocular pressure-lowering (IOP) therapy and to compare the frequency and severity of symptoms with the control group of normal subjects. Methods:This prospective, multicenter, observational study included patients with glaucoma in four different Departments of Ophthalmology. A matched group of normal subjects served as controls. For each patient we have collected detailed family history, clinical records and calculated ocular surface disease index (OSDI) scores (0-100), based on the information obtained from OSDI questionnaires. Results:In total, we have evaluated 160 patients. Of those, 110 were glaucoma patients and 50 were normal subjects. Among 110 glaucoma treated patients 83 (75%) had OSDI scores indicating mild to severe OSD. Among 50 patients without glaucoma 15 (30%) had OSDI score indicating mostly mild to moderate OSD. The severity of symptoms correlates with the number of IOP medications used and the duration of treatment. Conclusion:This study confirms the high prevalence of OSD in patients treated for glaucoma with topical IOP medications. The adverse effect of these agents can influence the compliance and successful treatment of glaucoma patients.

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Section: Discussionmentioning

confidence: 99%

Section: Clinical and Experimental Ophthalmologymentioning

confidence: 99%

Prevalence of Ocular Surface Disease in Patients with Glaucoma using Topical Antiglaucoma Medications

Barišić¹

2014

J Clin Exp Ophthalmol

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“…10 The German registry data found that women with glaucoma were significantly more likely to develop dry eye than men with glaucoma (56.9% versus 45.7%; p<0.0001). This is in agreement with other studies that found a predominance of DED in women, 5,6,8,11 but it seems to be an ethnic phenomenon because in Turkish normal volunteers 12 no significant differences in tear function between the genders have been observed, and in an Asian population the prevalence of DED was significantly higher in men compared with women.…”

Section: Gender and Age Differencesmentioning

confidence: 97%

“…This information has allowed the relationship between the occurrence of dry eye and potential causative factors to be dissected in detail. 10 Overall, 52.6% of glaucoma patients have a concomitant diagnosis of dry eye versus 47.4% who do not.…”

mentioning

confidence: 99%

Prevalence of Dry Eye Disease in Glaucoma

Erb¹

2009

European Ophthalmic Review

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Data from over 20,000 German patients with glaucoma have provided valuable information regarding the prevalence of dry eye disease (DED) in these patients. Overall, more women develop DED with glaucoma than men (56.9 versus 45.7%), and the prevalence increases with age, with more than half of patients 60 years of age having symptoms. Hypertension co-exists with glaucoma in 48.1% of patients, and the highest level of DED is found in patients with dry mouth, nose and skin (75.5%). DED occurs more often when three or more antiglaucoma eyedrops are used, and with longer disease duration. This suggests that it is related to the presence of the preservative benzalkonium chloride, and that using preservative-free eyedrops to break the vicious circle of DED is likely to enhance patient compliance and improve the care of glaucoma patients. KeywordsDry eye, glaucoma, preservative-free, compliance Disclosure: The author has no conflicts of interest to declare. Both glaucoma and DED are multifactorial disorders. 3,4 In a review of the prevalence of DED it was shown that the variation of prevalence of DED across studies is very high, differing from <0.1 to 33%, 5 depending on how DED was defined. However, in large studies the age-adjusted prevalences at >50 years of age in the US and Spain were from 3.9 to 11.9%, 6-8 and at ≥65 years between 15 to 34%. 9 At this age, the prevalence of DED increased with age and with female gender.Since glaucoma and DED are very common in the elderly, we were interested in the prevalence of DED in different glaucoma types and in a very large sample size. The German Glaucoma and Dry Eye Register includes analysable data from a total of 20,506 individuals with diagnosed glaucoma taken from 900 ophthalmological centres acrossGermany. This information has allowed the relationship between the occurrence of dry eye and potential causative factors to be dissected in detail. 10 Overall, 52.6% of glaucoma patients have a concomitant diagnosis of dry eye versus 47.4% who do not. Incidence of Concomitant DiseasesPatients were asked directly about any concomitant illnesses and vascular risk factors they were aware of being affected by, and 16 such health concerns are found to co-exist with glaucoma. Irrespective of glaucoma type, hypertension is the most frequent of these, being reported by 48.1% of patients, followed by diabetes (22.5%), dry mouth, nose and skin (11.3%) and obesity (11.2%). Overall, the presence of any concomitant disease increases the percentage of dry eye reported by glaucoma patients. Of those glaucoma patients with dry mouth, nose and skin, 75.5% also suffer from dry eye, and it is found in 68.2% of those with depressive episodes, 66.1% of those with arthritis and 65.6% of those with skin diseases. Gender and Age DifferencesThe gender distribution of the registry population is 60.9% female (n=12,493) and 39.1% male (n=8,013). 10 The German registry data found that women with glaucoma were significantly more likely to develop dry eye than men with glaucoma (56.9% versus 45...

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“…Various observational studies conducted in recent years in Europe and the US have shown a consistent prevalence of OSD in glaucoma of approximately 50 % (range: 40 %-60 %) [1][2][3][4][5] with 27 % of patients suffering from severe OSD (see Figure 1). …”

mentioning

confidence: 91%