Gestational Diabetes Mellitus in Iranian Women: a rising rate

Manafi, M

doi:10.4183/aeb.2013.71

Cited by 4 publications

(1 citation statement)

References 23 publications

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“…GDM is a known predisposing factor for future type 2 diabetes and obesity for both mother and child (2). According to a meta-analysis in 2015, the prevalence of GDM in IRAN was 3.41% (lowest and highest rates were 1.3, 18.6% respectively) (3) and it has markedly been increasing in recent years (4). Insulin resistance and reduction in the pancreatic beta cell reserve for insulin secretion contribute to the development of GDM (3,5).…”

Section: Introductionmentioning

confidence: 99%

Increased Serum Level of FGF21 in Gestational Diabetes Mellitus

2017

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Objective. Gestational diabetes mellitus (GDM) is a common endocrine complication in pregnancy. There are few risk factors that clearly correlate with GDM. Fibroblast growth factor 21 (FGF21) is a metabolic hormone that can regulate glucose metabolism. It has been recognized that serum levels of FGF21 are significantly increased in diabetes and insulin resistance states. The objective of this study was to determine the serum FGF21 levels in women with GDM compared with non-GDM women and its correlation with insulin resistance. Methods. Thirty GDM patients and 60 healthy pregnant controls that matched for maternal and gestational age were selected. Women with previous history of GDM, hypertension, polycystic ovary syndrome, renal or liver failure and drug consumption with effects on glucose or insulin levels were excluded. FGF21 was determined and correlated with biochemical parameters of glucose metabolism and insulin resistance. Results. FGF21 concentration was significantly higher in GDM (264.5±196.2 ng/L) as compared with control groups (59.1±36.5ng/L). Correlation of FGF21 with insulin resistance was not significant. A cutoff 82.07 ng/L of FGF21 had sensitivity of 100% and specificity of 85% for prediction of GDM. Conclusion. FGF21 is increased in GDM and it is independent of insulin resistance. We suggest that FGF21 resistance could be directly involved in pathophysiology of GDM.

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Section: Introductionmentioning

confidence: 99%

Increased Serum Level of FGF21 in Gestational Diabetes Mellitus

2017

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Prevalence of gestational diabetes mellitus in Eastern Mediterranean region: a systematic review and meta-analysis

et al. 2019

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Purpose Gestational diabetes mellitus (GDM) is one of the costly challenges in the health field. Despite the individual studies in the Eastern Mediterranean, there is no comprehensive study in this regard. The aim of this study was to determine the prevalence of GDM in the Eastern Mediterranean region. Methods In this meta-analysis and systematic review, three international databases (PubMed, Web of science and Scopus) were searched from inception until 30 December 2018. The Hui tool was used to assess the quality of the included studies. Results Thirty-three studies performed on 887166 participants were included in the meta-analysis. Based on the results of random effect method, the overall prevalence of GDM was 11.7%. Between six country with have three or more study, pooled prevalence for Saudi Arabi it was 3.6 times more than Israel (17.6 vs. 4.9%), and for Pakistan, Qatar, Bahrain and Iran were 15.3%, 14.7%, 12.2%, and 8.6%, respectively. Conclusion Despite the high diversity of methods, the results of the present study indicate a high prevalence of GDM in the Eastern Mediterranean region, indicating more policymakers' interest in timely screening and proper management.

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The Relationship between Gestational Diabetes and Risk Factors in Pregnant Women in Hamadan

Borzouei

Rabiei

Ashari

et al. 2018

psj

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Background and Objective:Gestational diabetes is a health problem and is one of the most commonly occurring complications of pregnancy worldwide, which has many effects on the mother and the fetus. The present study was conducted to determine the prevalence of gestational diabetes and its risk factors in Hamadan city, Iran. Materials and Methods:In this cross-sectional study, the study population was 534 pregnant women who were referred to control pregnancy to Hamadan health center from April 2014 to December 2016. Results: The study participants were 534 with the age range of 15-42 years old with an average age of 26.8 and a standard deviation of 5.56. The gestational age was 4 to 29 weeks with an average of 8.32 weeks with a standard deviation of 2.68. Of the 534 participants in this study, 211 (39.5%) had gestational diabetes and there was a significant relationship between factors such as macrosomia and history of impaired glucose tolerance with the prevalence of gestational diabetes. Conclusion: Gestational diabetes has a relatively high prevalence in Hamadan, further information is needed in this area as well as studies based on new guidelines in different parts of the country.

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Gestational Diabetes Mellitus in Iranian Women: a rising rate

Cited by 4 publications

References 23 publications

Increased Serum Level of FGF21 in Gestational Diabetes Mellitus

Increased Serum Level of FGF21 in Gestational Diabetes Mellitus

Prevalence of gestational diabetes mellitus in Eastern Mediterranean region: a systematic review and meta-analysis

The Relationship between Gestational Diabetes and Risk Factors in Pregnant Women in Hamadan

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