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Context. Rising incidence of Gestational diabetes mellitus (GDM) has been reported in the recent years and it has become an important public health problem, mainly among women aged 35-39 years.Objectives. Frequency of GDM in the females who are living in the northwest of Iran was evaluated.Subjects and Methods. Two hundred and fifty pregnant women at 24-28 th weeks of gestation were screened using 50 g oral glucose challenge test (OGCT), and the subjects with blood sugar levels equal or greater than 130 mg/dL were referred to diagnostic 100 g oral glucose tolerance test (OGTT). GDM was diagnosed according to Carpenter and Coustan criteria.Results. Eighty six women (34.4%) with positive result of screening test were selected for subsequent OGTT with 100g oral glucose. GDM was diagnosed in twenty four women (9.6 %) with at least 2 abnormal values. Frequency of GDM in the older subjects or the subjects with high pre-pregnancy or 24-28 th weeks' body mass index (BMI) were significantly higher than younger pregnant females or the subjects with low BMI.Conclusion. Prevalence of GDM in the current study was 11.9%, which is higher than earlier reports and implicates that the prevalence of gestational diabetes mellitus has markedly been increasing in Iran and associated with maternal age and body mass index.

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Our studies indicate that ghrelin ameliorates wasting, systemic hypertension and LVH with associated improvement in inflammation and mortality in CKD.http://dx.