Giant condyloma acuminatum in pregnancy: A case report

Cui, Tao; Huang, Jingwen; Lv, Bin; Yao, Qiang

doi:10.1111/dth.12972

Cited by 15 publications

(23 citation statements)

References 27 publications

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“…Nonsurgical treatments including topical treatment such as electrocautery therapy, CO2 laser vaporization, cryotherapy, topical imiquimod, intralesional injections of 5-FU or interferon and aminolevulinic acid photodynamic therapy (ALA-PDT), systemic treatment such as interferon-α2b, methotrexate, 5-FU, bleomycin, mitomycin C, cisplatin, and leucovorin. 5,6 In our case, the patient had T1DM and her fasting blood glucose 18.88 mmol/L, alanine aminotransferase and triglyceride was abnormal, concerned about wound healing, she was not suitable for invasive treatment. Our therapeutic schedule was to suggest the patient take medicines to reduce alanine aminotransferase and triglyceride and adjust blood glucose, after that, we planned to implement a combination of CO2 laser and ALA-PDT therapy.…”

Section: Discussionmentioning

confidence: 66%

“…Surgical excision is the first‐line therapy for GCA because it quickly removes the large mass. Nonsurgical treatments including topical treatment such as electrocautery therapy, CO2 laser vaporization, cryotherapy, topical imiquimod, intralesional injections of 5‐FU or interferon and aminolevulinic acid photodynamic therapy (ALA‐PDT), systemic treatment such as interferon‐α2b, methotrexate, 5‐FU, bleomycin, mitomycin C, cisplatin, and leucovorin 5,6 …”

Section: Discussionmentioning

confidence: 99%

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A rare case of self‐healing giant condyloma acuminatum

Jin

Liu

et al. 2021

Dermatologic Therapy

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Giant condyloma acuminatum (GCA) which is also called Buschke-Lowenstein tumor.It is a rare tumor of the anorectal area and external genitalia associated with low-risk HPV types 6 or 11. GCA has a high-rate of recurrence (66%) and malignant transformation (56%). The clinical features of GCA are progression of exophytic, ulcerative, and cauliflower-shaped tumors, it has significant dimensions and may undergo malignant transformation such as squamous cell carcinoma or cervical cancer. It is difficult to treat GCA, and it may be impossible for GCA to self-healing, but we herein report a rare case of a 19-year-old female with self-healing GCA.

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Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

A rare case of self‐healing giant condyloma acuminatum

Jin

Liu

et al. 2021

Dermatologic Therapy

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“…In the most recent series of cases, a 2.7 : 1 male/female ratio was reported, with an age range of 24 to 77 years, a mean age of 43.9 years (42.9 years in men and 46.6 years in women), and a tendency to present at younger ages [ 5 ]. Very few cases have been described in pregnant women [ 10 ]. Although it is considered a sexually transmitted disease and sexual abuse should always be suspected when it occurs in pediatric age, cases not associated with sexual transmission have been described, suggesting a mechanism of autoinoculation and heteroinoculation [ 11 ].…”

Section: Epidemiology and Risk Factorsmentioning

confidence: 99%

“…During pregnancy it is suggested to defer surgical management until after delivery because it is associated with spontaneous abortion, intrapartum hemorrhage, preterm delivery, low birth weight. Delivery must be carried out by caesarean section to avoid vertical transmission [ 10 ].…”

Section: Clinical Managementmentioning

confidence: 99%

Giant Condyloma Acuminata (Buschke-Lowenstein Tumor): Review of an Unusual Disease and Difficult to Manage

Condoy

Acuña-Pinzón

Chavarría-Chavira

et al. 2021

Infectious Diseases in Obstetrics and Gynecology

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Giant condyloma acuminatum (GCA) or Buschke-Loewenstein tumor is a rare disease, with an estimated prevalence of 0.1%. It was initially described in 1896 by Buschke and later in 1925 by Buschke and Loewenstein. Classic condyloma acuminata (CCA) and squamous cell carcinoma (SCC) were initially described as different entities. These three entities are currently considered to correspond to the same spectrum of different but not exclusive malignant transformations, associated with multiple risk factors such infection by human papilloma virus (HPV), immunodeficiencies, poor hygiene, multiple sexual partners, and chronic genital infections. HPV subtypes 6 and 11 are associated with 90% of GCA. It presents as a cauliflower-like tumor in the genital region with bad odor, bleeding, and local infection, differential diagnosis with multiple conditions should be considered, and sexually transmitted diseases should always be investigated. GCA has a higher rate of malignant transformation than CCA and tends to infiltrate adjacent soft tissues. The therapeutic approach is controversial but is considered that the resection with free edges is the gold standard and can be combined with adjuncts. The recurrence rate is high. Overall mortality is 21% and is associated with morbidity caused by recurrences. Imiquimod cream 5% has recently shown good results as monotherapy and in combination with ablative and surgical treatments. The quality of life is diminished in patients with this condition. In this review, we address the different aspects of this rare entity including the therapeutic approach.

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“…1 GCA can present as a cauliflower-like lesion 2 with broad-based papillomas up to several centimeters in diameter or as large confluent plaques. These lesions mostly occur in the perineum, vulva, vagina, perianal region and rectum, 3 rarely developing in extragenital areas. 4 Because these lesions frequently recur, being benign but contagious, lack a definitive form of treatment, and their treatment is expensive, 5 they can adversely affect patients' functioning and psychological health.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Giant Condyloma Acuminatum with Monotherapy of Topical Traditional Chinese Medicine: Report of Eight Cases

Wang¹,

Li²,

Li³

2021

IDR

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Background: Giant condyloma acuminatum (GCA), also called Buschke-Löwenstein tumor, presents as a verrucous infiltrating lesion and is caused by sexual transmission of human papilloma virus. The optimal treatment is controversial and there are no standard guidelines because of its rarity and frequent recurrence. It has a relatively high local recurrence rate. Objective: We here report eight patients (six men and two women) with GCA whose lesions were successfully treated topically with traditional Chinese medicine (TCM) preparations, paiteling. Methods and Materials: We administered topical TCM preparations to eight patients diagnosed with GCA who had refused surgery. The treatment process included three stages, their durations depending on the speed of resolution of the lesions and the results of visual inspection with acetic acid. Results: No significant complications occurred in any patient. The functional and esthetic outcomes were satisfactory. No recurrences were detected during follow-up. Conclusion:Topical treatment with TCM preparations may be a good alternative to surgery or other traditional methods for the treatment of GCA. This treatment has the advantages of being non-invasive, painless, and having a low risk of recurrence, and may be a useful adjunct to mainstream medical treatments.

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Giant condyloma acuminatum in pregnancy: A case report

Cited by 15 publications

References 27 publications

A rare case of self‐healing giant condyloma acuminatum

A rare case of self‐healing giant condyloma acuminatum

Giant Condyloma Acuminata (Buschke-Lowenstein Tumor): Review of an Unusual Disease and Difficult to Manage

Efficacy and Safety of Giant Condyloma Acuminatum with Monotherapy of Topical Traditional Chinese Medicine: Report of Eight Cases

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