Giant condyloma acuminatum–malignant transformation

Papapanagiotou, Ioannis; Migklis, Kyriaki; Ioannidou, Georgia; Xesfyngi, Dimitra; Kalles, Vasileios; Mariolis‐Sapsakos, Theodoros; Terzakis, E

doi:10.1002/ccr3.863

Cited by 10 publications

(8 citation statements)

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“…GCA features tendency toward local recurrence and conversion into squamous cell carcinoma (Chao & Gibbs, ; Papapanagiotou et al, ). The risk of recurrence in the anorectal and perianal regions after excision is 60–66%, with an overall mortality of 20–30%.…”

Section: Discussionmentioning

confidence: 99%

Giant condyloma acuminatum in pregnancy: A case report

Cui

Huang

et al. 2019

Dermatologic Therapy

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The giant condyloma acuminatum (GCA), also known as Buschke–Löwenstein tumor (BLT), is a type of human papilloma virus‐associated sexually transmitted infection. Treatment options for condyloma acuminatum remain controversial, but surgery seems to be the best option. The management of GCA during pregnancy is more complicated since one has to evaluate the condition of both the mother and the fetus. In this report, we presented a GCA case in a pregnant woman with giant masses that covered the perineal and perianal region. Considering the gestational age and the fetal neurological risk from the anticipated lengthy procedure of mass removal surgery for tumor of this size, we decided to resect the tumor 2 weeks after the infant was delivered via C‐section.

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Section: Discussionmentioning

confidence: 99%

Giant condyloma acuminatum in pregnancy: A case report

Cui

Huang

et al. 2019

Dermatologic Therapy

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“…T lymphocyte subsets disorder can lead to imbalance of Th1/Th2 ratio, that is, the secretion of IL-2 and IFN-γ and other cytokines by Th1 cell decrease, while the secretion of IL-4 and IL-10 and other cells factors by Th2 cells increase. Reduced Th1/Th2 ratio is closely correlated with the development of CA ( 11 , 12 ). Erman-Vlahovic et al ( 13 ) found that peripheral blood levels of IL-2 and IFN-γ were significantly lower, while levels of IL-4 and IL-12 were significantly higher in CA patients than in healthy controls.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effect of photodynamic therapy combined with imiquimod in the treatment of anal condyloma acuminatum and its effect on immune function

Meng

Luan

et al. 2018

Exp Ther Med

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Therapeutic effect of photodynamic therapy combined with imiquimod in the treatment of anal condyloma acuminatum (CA) was investigated to explore its effect on immune function. A total of 104 patients with anal CA were randomly divided into two groups: Patients in the study group were treated with photodynamic therapy combined with imiquimod, and ii) patients in the control group were treated with recombinant human interferon α-2b cream. Clinical efficacy and immune function related indicators were compared between the two groups. After treatment for 6 weeks, the cure rate and total effective rate of study group was 53.85 and 92.31%, respectively, which were significantly higher than those of the control group (30.77 and 75.00%, P<0.05). Recurrence rate of study group was 3.85% within 6 months after treatment, which was significantly lower than that of the control group (19.23%, P<0.05). After treatment, levels of CD4+, CD4+/CD8+ and IFN-γ in the study group were significantly higher than those in the control group, and levels of CD8+, IL-4 and IL-10 in the study group were significantly lower than those in the control group (P<0.05). Photodynamic therapy combined with imiquimod in the treatment of anus CA can regulate T lymphocyte subsets and cytokine levels, enhance immune function, improve clinical efficacy, reduce recurrence rate, and have almost no side effects. Therefore, this treatment should be popularized in clinical practice.

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“…When SCC occurs in the context of GCA, management must be approached from the context of the patient and sometimes, only palliative measures can be offered to avoid more comorbidities [ 24 ].…”

Section: Clinical Presentationmentioning

confidence: 99%

Giant Condyloma Acuminata (Buschke-Lowenstein Tumor): Review of an Unusual Disease and Difficult to Manage

Condoy

Acuña-Pinzón

Chavarría-Chavira

et al. 2021

Infectious Diseases in Obstetrics and Gynecology

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Giant condyloma acuminatum (GCA) or Buschke-Loewenstein tumor is a rare disease, with an estimated prevalence of 0.1%. It was initially described in 1896 by Buschke and later in 1925 by Buschke and Loewenstein. Classic condyloma acuminata (CCA) and squamous cell carcinoma (SCC) were initially described as different entities. These three entities are currently considered to correspond to the same spectrum of different but not exclusive malignant transformations, associated with multiple risk factors such infection by human papilloma virus (HPV), immunodeficiencies, poor hygiene, multiple sexual partners, and chronic genital infections. HPV subtypes 6 and 11 are associated with 90% of GCA. It presents as a cauliflower-like tumor in the genital region with bad odor, bleeding, and local infection, differential diagnosis with multiple conditions should be considered, and sexually transmitted diseases should always be investigated. GCA has a higher rate of malignant transformation than CCA and tends to infiltrate adjacent soft tissues. The therapeutic approach is controversial but is considered that the resection with free edges is the gold standard and can be combined with adjuncts. The recurrence rate is high. Overall mortality is 21% and is associated with morbidity caused by recurrences. Imiquimod cream 5% has recently shown good results as monotherapy and in combination with ablative and surgical treatments. The quality of life is diminished in patients with this condition. In this review, we address the different aspects of this rare entity including the therapeutic approach.

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Giant condyloma acuminatum–malignant transformation

Cited by 10 publications

References 0 publications

Giant condyloma acuminatum in pregnancy: A case report

Giant condyloma acuminatum in pregnancy: A case report

Therapeutic effect of photodynamic therapy combined with imiquimod in the treatment of anal condyloma acuminatum and its effect on immune function

Giant Condyloma Acuminata (Buschke-Lowenstein Tumor): Review of an Unusual Disease and Difficult to Manage

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