Giant Migrating Contractions During Defecation in the Dog Colon

Karaus, M.; Sarna, Sushil K.

doi:10.1016/0016-5085(87)90966-8

Cited by 127 publications

(87 citation statements)

References 15 publications

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“…3C and 4C). In addition, itopride produced giant migrating contractions, which were high-amplitude, rapidly migrating contractions that propelled colonic contents to the rectum (Sarna et al, 1984;Karaus and Sarna, 1987), followed by defecation in some dogs at 10 mg/kg, but this was not seen with cisapride nor mosapride. Throughout this experiment, no behavioral changes were observed.…”

Section: Resultsmentioning

confidence: 99%

Stimulatory Action of Itopride Hydrochloride on Colonic Motor Activity in Vitro and in Vivo

Tsubouchi

Saito²,

Mizutani³

et al. 2003

J Pharmacol Exp Ther

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Section: Resultsmentioning

confidence: 99%

Stimulatory Action of Itopride Hydrochloride on Colonic Motor Activity in Vitro and in Vivo

Tsubouchi

Saito²,

Mizutani³

et al. 2003

J Pharmacol Exp Ther

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“…Therefore, T-1815 appears to have a characteristic to cause high-amplitude contractions in the proximal site of the colon rather than in the distal sites, and it may not cause the contractions to migrate to the distal site by the reason mentioned above. Sarna et al (1987) have also reported that, in conscious dogs, such high-amplitude (giant) contractions can easily occur at the proximal region of the colon, and the majority of the proximally originated contractions migrate caudad before defecation.…”

Section: Discussionmentioning

confidence: 94%

“…Thus, the pharmacological property of T-1815 is probably different from that of cholinergic agonists. Karaus and Sarna (1987) have found that, in conscious dogs, the high-amplitude contractions which migrate to the distal colon precede the spontaneous and chemically induced defecation, and they called these contractions 'giant migrating contractions'. A similarly unique motility of the colon was also observed in humans by Narducci et al (1987) and MorenoOsset et al (1989).…”

Section: Discussionmentioning

confidence: 99%

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Effect of a new Colonic Prokinetic Compound, T-1815, on Gastrointestinal Motility in Anesthetized and Conscious Fasted Dogs.

Yamada

Onoda

1993

J. Smooth Muscle Res.

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Effect of T-1815, a new colonic prokinetic compound, on gastrointestinal motility was studied in anesthetized and conscious dogs fasted for 24 hr before experiment.In anesthetized dogs, intravenous injection of T-1815 in doses of 0.3-3.0 mg/kg caused a biphasic effect on the gastric motility, a slight decrease followed by a slight increase. While the compound elicited only an increase in motility of the duodenum, jejunum and colon. In the colon, high- From the above results, it is concluded that the pharmacological effect of T-1815 on gastrointestinal motility is different from that of the cholinergic agonist. In addition, T-1815 seems to have a characteristic to induce high-amplitude contractions which are known to be closely related to defecation.

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“…The colonic motor correlates of defecation is the GMC [62] , whose amplitude is 2.5-2.8 times greater than the amplitude of phasic contractions during CMMCs. GMCs migrate either over the entire colon or a part of its length.…”

Section: Giant Migrating Contractionsmentioning

confidence: 92%

Effects of radiation upon gastrointestinal motility

Otterson¹

2007

WJG

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neural and chemical control. Myogenic control refers to the electrical activity generated by the smooth muscle of the gut. Electrical control activity (ECA) [1][2][3][4] is the omnipresent rhythmic depolarization of the cell membranes of the smooth muscle of the small intestine. With neural or chemical stimulation, membrane depolarization exceeds an excitation threshold and a contraction results. The electrical correlate of a contraction is called electrical response activity (ERA) [1][2][3][4] . These bursts of electrical response activity have a 1:1 relationship with contractions. Because ERA occurs only during the depolarization phase of the ECA cycle, the frequency of contractions is limited to and determined by the frequency of ECA. Neural and chemical stimulation may not be present during each depolarization of ECA, and thus contractions then do not occur at the maximum possible frequency (Figure 1). Recordings of gastrointestinal motility can either be made with devices that record physical contractions (manometry catheter or strain gauges) or motility can be implied from electrical activity or transit times.Single dose (938 Gy) in a canine model disrupted normal electrical patterns [5] . Jejunal myoelectric activity decreased in frequency, duration and length of migration o f E R A p o s t p r a n d i a l l y. E C A wa s i r r e g u l a r w i t h nonuniform morphology and occasionally migrated in an orad direction. ECA was occasionally uncoupled; coupling is a phenomenon in which corresponding ECAs recorded from different areas maintain a consistent time shift [6] . In spite of these functional abnormalities, the histology was minimally altered. These changes in electrical activity suggest a profound change in the physiology of the smooth muscle as well as the nerves controlling the muscle.Gastrointestinal smooth muscle contractile activity can also be influenced by extrinsic autonomic (parasympathetic and sympathetic) from the CNS and the intrinsic neurons of the enteric ner vous system. The stomach, small intestine and proximal colon derive their parasympathetic innervation through the vagus nerve which contains both afferent and efferent fibers. Relative to the intrinsic enteric neurons, the efferent potion of the vagus is really quite small; however, each vagal efferent fiber may influence about 2000 enteric neurons [7,8] . The sensory component of the vagus nerve is much greater. Sensory fibers account for 80% of all vagal fibers [9] . Vagal afferents detect both the mechanical and chemical stimulation of the small intestine and relay this information centrally for processing. Sympathetic innervation of the intestine arises from the thoracic and lumbar spinal nerves. These �� Effects of radiation upon gastrointestinal motility AbstractWhether due to therapeutic or belligerent exposure, the gastrointestinal effects of irradiation produce symptoms dreaded by a majority of the population. Nausea, vomiting, diarrhea and abdominal cramping are hallmarks of the prodromal ph...

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Giant Migrating Contractions During Defecation in the Dog Colon

Cited by 127 publications

References 15 publications

Stimulatory Action of Itopride Hydrochloride on Colonic Motor Activity in Vitro and in Vivo

Stimulatory Action of Itopride Hydrochloride on Colonic Motor Activity in Vitro and in Vivo

Effect of a new Colonic Prokinetic Compound, T-1815, on Gastrointestinal Motility in Anesthetized and Conscious Fasted Dogs.

Effects of radiation upon gastrointestinal motility

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