Giant Mixed Tumor of the Face

Kakuta, Mie; Tsuboi, Ryoji; Yamazaki, Masashi; Sakuma, Masayoshi; Yoshikata, Rie; Ogawa, Hideoki

doi:10.1111/j.1346-8138.1996.tb04034.x

Cited by 19 publications

(15 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4). [23]. Assays that can be performed on FFPE tumor specimens are needed to evaluate the genetic relationship between pleomorphic adenomas and cutaneous mixed tumors.…”

Section: Resultsmentioning

confidence: 99%

PLAG1 expression in cutaneous mixed tumors: an immunohistochemical and molecular genetic study

2011

View full text Add to dashboard Cite

Cutaneous mixed tumors, also known as chondroid syringomas, are benign cutaneous adnexal tumors that exhibit remarkable histopathological similarities to pleomorphic adenoma of the salivary gland. Thus far, there is little information on the genetic profiles of cutaneous mixed tumors, although specific genetic aberrations including fusion genes involving PLAG1 and HMGA2 have been demonstrated in pleomorphic adenomas. In the present study, we conducted an immunohistochemical evaluation of PLAG1 and a reverse transcription-polymerase chain reaction (RT-PCR) assay to detect fusion gene transcripts associated with pleomorphic adenoma, including the CTNNB1-PLAG1, LIFR-PLAG1, CHCHD7-PLAG1, TCEA1-PLAG1, HMGA2-FHIT, HMGA2-NFIB, and HMGA2-WIF1 fusion transcripts; this was performed using formalin-fixed paraffin-embedded tumor tissue specimens of 16 cutaneous mixed tumors including one sample with an adenocarcinoma component. All 16 cutaneous mixed tumors were immunoreactive to PLAG1, which was predominantly expressed in cells with myoepithelial or chondroid differentiation accounting for >80% of cells, whereas PLAG1 expression in glandular or squamous tumor cells was restricted to <20% of cells. The carcinoma component in the mixed tumor was also positive for PLAG1. On the other hand, all eight cutaneous adnexal tumors other than the mixed tumor were negative for PLAG1. In RT-PCR analysis, no fusion gene transcripts involving PLAG1 or HMGA2 were identified in any of the cases. Concordant with previous studies, our results support the close relationship between cutaneous mixed tumors and pleomorphic adenomas of the salivary gland. However, the mechanism of PLAG1 expression in cutaneous mixed tumors appears to be possibly different from that of pleomorphic adenomas.

show abstract

“…4). [23]. Assays that can be performed on FFPE tumor specimens are needed to evaluate the genetic relationship between pleomorphic adenomas and cutaneous mixed tumors.…”

Section: Resultsmentioning

confidence: 99%

PLAG1 expression in cutaneous mixed tumors: an immunohistochemical and molecular genetic study

2011

View full text Add to dashboard Cite

show abstract

“…[7] There is a male predilection and most lesions are between 1 and 3 cm in diameter, although examples as large as 10 cm have been reported. [89]…”

Section: Discussionmentioning

confidence: 99%

Chondroid syringoma: A case with unusual cytological findings

Khan

2013

Indian J Dermatol

View full text Add to dashboard Cite

Chondroid syringoma is a rare benign skin adnexal tumor, the cytological features of which have been published very rarely in the literature. A mucoid aspirate, abundant chondromyxoid matrix material, and epithelial components were suggested as diagnostic criteria. The reported case is one of chondroid syringoma confirmed by histopathology, the fine needle aspiration cytology of which yielded thin fluid-like material and microscopy revealed epithelial clusters with admixed smaller myoepithelial cells, background cyst macrophages, and only scanty chondromyxoid stromal elements. Including these cytological features of the present case among the diagnostic criteria for cytodiagnosis of chondroid syringomas might increase the chances of a definitive preoperative diagnosis and help in planning the extent of surgery.

show abstract

“…Including the cytologic features among the diagnostic criteria for a cytodiagnosis of CS has been reported to potentially increase the chances of a definitive preoperative diagnosis and help in planning the extent of surgery (9). Mitosis, nuclear atypia, pleomorphism, lymphatic invasion, and local recurrence have been recognized as helpful signs for the diagnosis of malignancy (17,18,21,25,26). None of these features were present in our patient.…”

Section: Discussionmentioning

confidence: 69%