Giant pilomatrixoma: a distinctive clinical variant: a new case and review of the literature.

Sabater‐Abad, Javier; Matellanes‐Palacios, María; Bou‐Boluda, Laia; Campos-Dana, Juan José; Alemany-Monraval, Pilar; Millán-Parrilla, Fernando

doi:10.5070/d3268049893

Cited by 9 publications

(7 citation statements)

References 10 publications

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“…Such pilomatrixomas may be misdiagnosed as malignant tumors. 7 Pilomatrixoma with bullous appearance is rarely reported, appearing in 3%-6% of cases, 8 most commonly seen on the upper arm and shoulder regions, unlike other types of pilomatrixoma types. 9 The main causes of such type of pilomatrixoma are mechanical irritation and trauma.…”

Section: Discussionmentioning

confidence: 99%

“…Sabater‐Abad also reported giant pilomatrixoma (>4 cm), of which 70 cases have been reported so far, and 40% of which were ulcerated. Such pilomatrixomas may be misdiagnosed as malignant tumors 7 . Pilomatrixoma with bullous appearance is rarely reported, appearing in 3%–6% of cases, 8 most commonly seen on the upper arm and shoulder regions, unlike other types of pilomatrixoma types 9 .…”

Section: Discussionmentioning

confidence: 99%

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Giant pilomatrixoma with bullous appearance on the back: A case report and discussion of misdiagnosis

Zhang

Chen

et al. 2022

J of Cosmetic Dermatology

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Pilomatrixoma is a superficial, benign skin tumor arising from hair follicle matrix cells. 1 It often occurs on the head, face, or neck, 2 rarely on the back or extremities. 3 Its common clinical appearance is a hard, well-circumscribed, slow-growing intradermal nodule covered by the skin of normal appearance or skin whose color has changed secondary to epithelial thinning. 4 In the dermatology and

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Giant pilomatrixoma with bullous appearance on the back: A case report and discussion of misdiagnosis

Zhang

Chen

et al. 2022

J of Cosmetic Dermatology

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“…Pilomatricoma is usually less than 1.5 cm in diameter [ 25 ]. However, cases of giant pilomatricoma have been reported, and this term was applied to tumors with a diameter of more than or equal to 4 cm [ 26 ]. Of all case reports that we reviewed, information on the size of the tumor was available for 13 (81.25%) lesions.…”

Section: Discussion/conclusionmentioning

confidence: 99%

Keloid-like Pilomatricoma of the Auricle: A Case Report and Review of Literature

et al. 2022

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Pilomatricoma is a rare benign skin adnexal tumor arising from hair matrix cells. It usually manifests as a firm-to-hard, well-circumscribed, nontender nodule often mistaken as a dermoid cyst. However, its clinical presentation has been reported to mimic keloid. In addition, although it occurs most frequently in the head and neck area, pilomatricoma is rarely reported on the auricle. Herein, we reported a case of pilomatricoma occurring on the posterior part of a 9-year-old girl’s auricle. Unlike classic pilomatricoma, the tumor closely resembled a keloid. Nevertheless, histological examination following excision of the tumor revealed a dermal tumor arranged in solid nests consisting of basaloid and ghost cells along with foreign body reaction, calcification, and ossification, confirming the diagnosis of pilomatricoma. The rarity, atypical clinical presentation, and unique location of this tumor contributed to the misdiagnosis of this case. Therefore, we reviewed previous cases of pilomatricoma of the auricle reported in the literature to provide a comprehensive understanding of this rare entity.

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“…Giant PMs are a rare World Health Organization (WHO)-acknowledged PM variant that is greater than 4 cm in size, frequently ulcerate and are more likely to simulate a malignant neoplasm on clinical exam. 4 Most PMs harbor mutations in the CTNNB1 gene 5 leading to constitutive beta-catenin/lymphoid enhancer binding factor (LEF) target gene activation to control proliferation, differentiation, and survival. 6,7 Simultaneous gain of chromosome 18 harboring the BCL2 apoptosis regulator (BCL2) gene is also a recurrent abnormality accompanied by BCL2 protein overexpression.…”

Section: Introductionmentioning

confidence: 99%

“…Overlying skin may appear normal or show red or bluish discoloration with ulceration. Giant PMs are a rare World Health Organization (WHO)‐acknowledged PM variant that is greater than 4 cm in size, frequently ulcerate and are more likely to simulate a malignant neoplasm on clinical exam 4 …”

Section: Introductionmentioning

confidence: 99%

Spatial transcriptomics of a giant pilomatricoma

Patil,

Bennett,

et al. 2023

J Cutan Pathol

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Pilomatricomas (PMs) are common benign adnexal tumors that show a predilection for the head and neck region and are characterized at the molecular level by activating mutations in the beta‐catenin (CTNNB1) gene. Giant PMs are a rare histopathological variant, according to the World Health Organization, which are defined by a size greater than 4 cm and are reported to show upregulation of yes‐associated protein compared to PMs of typical 1–3 cm size. We describe the case of a 67‐year‐old man with an 8 cm giant PM involving his temporal scalp, whose PM we characterized by 10X spatial gene expression analysis. This revealed five total transcriptomic clusters, including four distinct clusters within the giant PM, each with a unique transcriptional pattern of hair follicle‐related factors, keratin gene expression, and beta‐catenin pathway activity.

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Giant pilomatrixoma: a distinctive clinical variant: a new case and review of the literature.

Cited by 9 publications

References 10 publications

Giant pilomatrixoma with bullous appearance on the back: A case report and discussion of misdiagnosis

Giant pilomatrixoma with bullous appearance on the back: A case report and discussion of misdiagnosis

Keloid-like Pilomatricoma of the Auricle: A Case Report and Review of Literature

Spatial transcriptomics of a giant pilomatricoma

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