Conventional acne treatment presents several challenges such as intolerable side effects and antibiotic resistance. Dermocosmetic products may be used to reduce these unwanted effects. Dermocosmetics include skin cleansers, topical sebum-controllers, skin antimicrobial/anti-inflammatory agents, moisturizers, sunscreens, and camouflage products. Appropriate use of these products may help augment the benefit of acne treatment, minimize side effects, and reduce the need for topical antibiotics. In Asia, there is currently limited scientific data on the application and recommendations for dermocosmetic use in acne vulgaris (AV). This article reviews the evidence on dermocosmetics for AV and provides practice recommendations as discussed during the 4th Asia-Pacific Acne Leaders' Summit held in Bangkok, Thailand, on 7 and 8 February 2015. Through a premeeting survey, a series of plenary lectures, a stepwise program of discussion sessions, and Medline article review, the Expert Panel set forth relevant recommendations on the role of dermocosmetics as adjunct for treating AV in Asian patients.

Glutathione is a potent antioxidant, which is widely used in skin care products for skin lightening especially in the Asian market. Presently, there was only one study of topical 2% oxidized glutathione (GSSG) in Philipino women, further study is needed to evaluate the efficacy and safety of cosmetic products containing glutathione. A double blind randomized clinical trial study was conducted in Yogyakarta, Indonesia, in 74 healthy Indonesian women, with average age 33.3 ± 5.9 years when subjects participated in the study. Each subject received supervised applications of Facial Wash twice a day, Day Cream with sunscreen and Night Cream. The subjects were divided into 3 groups based on the active ingredients of the tested products, which included glutathione reduced (GSH) 0.1%, GSH 0.5%, and without GSH. The effects of the tested products in lightening skin color and pigmentation were measured colorimetry with Chromameter Minolta for L*. Compared to a baseline, there were significant increases of L* (lightness) or ΔL* detected as early as week 2 in which group of GSH 0.1% were significantly higher compared to group of GSH 0.5% and group without GSH. Hyperpigmented lesions also improved, where GSH 0.5% group showed its superiority compared to others groups in week 8. The undesired effect were few minutes mild tingling sensation after night cream, and worsening of acne in all tested products. Conclusion skin care products containing GSH 0.1% and 0.5% were effective in facial skin lightening.

Dandruff is a common symptom in adolescence, which possibly due to increasing of Malassezia sp. colonization, sebum level as well as skin hydration. Wearing hijab is predicted to increase the humidity and sebum level lead to increase the number of Malassezia sp. and dandruff severity. A case-control study was conducted on 19 female with dandruff who wear hijab and 19 female with dandruff who do not wear hijab, age between 18 and 27 years old. The dandruff severity was defined clinically using a scoring system (0-100), only subjects with minimum score of 28 will be included in this study. The sebum and trans epidermal water loss (TEWL) levels were measured with Sebumeter and Tewameter from Courage Khazaka. The Malassezia sp. was examined using microscopic examination of the squama and culture in the Saboraud medium. There were no significant differences found between hijab and non-hijab groups for dandruff severity. No difference found between two groups for sebum level, Malassezia sp. number microscopically, and Malassezia sp. colonization. Only TEWL level in hijab group that was found to be higher than non-hijab group. Wearing hijab does not increase the dandruff severity, sebum level and colonization number of Malassezia sp. Wearing hijab is found to increase the TEWL level. ABSTRAK Ketombe merupakan gejala umum pada masa remaja, yang disebabkan oleh meningkatnya coloni Malassezia sp., tingkat sebum serta hidrasi kulit. Penggunaan jilbab diperkirakan menyebabkan peningkatan kelembaban dan sebum yang akan meningkatkan jumlah Malassezia sp. dan tingkat keparahan ketombe. Sebuah studi kasus-kontrol dilakukan pada 19 wanita berketombe yang memakai jilbab dan 19 wanita berketombe yang tidak memakai jilbab, usia antara 18 dan 27 tahun. Keparahan ketombe didefinisikan secara klinis menggunakan sistem penilaian (0-100), hanya subjek dengan skor minimal 28 yang akan dimasukkan dalam penelitian ini. Tingkat sebum dan trans epidermal water loss (TEWL) diukur dengan Sebumeter dan Tewameter dari Courage Khazaka. Malassezia sp. diperiksa menggunakan pemeriksaan mikroskopik dari skuama dan kultur dalam medium Saboraud. Tidak ada perbedaan signifikan yang ditemukan antara kelompok hijab dan non-hijab untuk keparahan ketombe. Tidak ada perbedaan yang signifikan ditemukan antara dua kelompok untuk tingkat sebum, jumlah Malassezia sp. secara mikroskopis, dan koloni Malassezia sp. Ditemukan tingkat TEWL kelompok berhijab lebih tinggi daripada kelompok non-hijab. Memakai jilbab tidak meningkatkan keparahan ketombe, tingkat sebum, serta jumlah kolonisasi Malassezia sp. Memakai hijab meningkatkan tingkat TEWL.

Eitoderma merupakan peradangan kulit yang mengenai 90% atau lebih permukaan kulit. Limfoma selT kulit (cutaneous T-cell lymphoma atau CTCL) merupakan salah satu penyebab eritroderma. Prognosis penyakitini buruk, karena rerata pasien hanya mampu bertahan 2 tahun, oleh karena itu diagnosis eritrodermakarena CTCL menjadi sangat penting.Seorang lelaki usia 65 tahun datang dengan keluhan utama muncul kulit merah dan mengelupas padahampir seluruh tubuh sejak 1 bulan sebelum periksa ke rumah sakit. Satu minggu sebelumnya, pasien mengeluhkulit merah dan mengelupas, terasa gatal, badan terasa panas, rambut rontok, kuku menjadi tebal dankekuningan, demam hingga menggigil. Didapatkan limfadenopati di daerah inguinalis dekstra. Status dermatologispada hampir seluruh tubuh tampak bercak eritematosa dengan deskuamasi berwarna putih di atasnya,multipel dan tersebar. Pada pemeriksaan darah rutin didapatkan sel Sezary. Hasil pemeriksaan histopatologismenunjukkan sebukan band like sel limfosit atipik di dermis. Selain itu didapatkan juga mikroabses Pautrier.Pengecatan imunohistokimia CD3+ dan CD4+ menunjukkan hasil positif. Lesi membaik dengan terapi injeksimetilprednisolon intravena 62,5 mg/hari selama 7 hari.Penyebab eritroderma pada kasus ini adalah CTCL yang ditegakkan dengan anamnesis, pemeriksaan fisisdan penunjang terutama darah lengkap dan pemeriksaan histopatologis.Kata kunci: eritroderma, CTCL

Acne vulgaris is a multifactorial disorder characterized by seborrhea, microcomedones, comedones, papules, pustules, nodules and possibly scarring. The pathogenesis of acne is not completely understood. Recent studies reported the possible role of reactive oxygen spesies (ROS) especially lipid peroxides in mediating acne inflammation. Malondialdehyde (MDA) is one of the final products of the lipid peroxidation that commonly used as a lipid peroxidation marker. This study was conducted to evaluate the correlation between serum MDA levels and severity of acne on male patients. A total 60 patients with acne who attended in Polyclinic of Department of Dermatology and Venereology, Dr Sardjito General Hospital and met the inclusion and exclusion were involved in the study. The patients were then classified using combined acne severity classification method into three group as mild, modrate and severe acnes. Blood sample were then taken from all subjects and serum MDA levels were determined spectrophotometer. The mean serum MDA levels of severe acne group (1.85 ± 0.368 μmol/L) were significantly higher than that moderate acne group (0.79 ± 0.159 μmol/L) (p = 0.000) and that mild acne group (0.52 ± 0.239 μmol/L) (p = 0.000). Moreover, the mean MDA levels of moderate acne group were also significantly higher than that mild acne group (p = 0.002). Significantly positive correlation was observed between serum MDA levels and acne lesions total count (r = 0.714; p = 0.000). It can be concluded, there is positive relationship between serum MDA levels and severity of acne vulgaris on male patients. ABSTRAK Jerawat adalah penyakit multifaktor yang ditandai dengan seborea, mikrokomedo, komedo, papul, pustula, nodul dan kemungkinan jaringan parut. Patogenesis jerawat belum sepenuhnya diketahui. Penelitian terkini melaporkan kemungkinan peran reactive oxygen species (ROS) khususnya peroksidasi lemak dalam timbulnya inflamasi. Malondialdehid (MDA) adalah hasil akhir peroksidasi lemak yang umumnya digunakan sebagai penanda peroksidasi lemak. Penelitian ini dilakukan untuk mengkaji hubungan antara kadar MDA serum dengan tingkat keparahan jerawat pada pasien laki-laki. Total sebanyak 60 pasien dengan jerawat yang berkunjung ke Poliklinik Bagian Kulit dan Kelamin, RSUP Dr. Sardjito yang memenuhi kriteria inklusi dan eksklusi terlibat dalam penelitian. Pasien dikelompokkan dengan metode combined acne severity classification dalam tiga kelompok yaitu pasien dengan jerawat ringan, sedang dan berat. Sampel darah seluruh pasien diambil dan ditetapkan kadar MDA serumnya dengan spektrofotometer. Rerata kadar MDA serum pasien dengan jerawat berat (1,85 ± 0,368 μmol/L) lebih tinggi secara nyata dibandingan dengan pasien dengan jerawat sedang (0,79 ± 0.159 μmol/L) (p = 0,000) dan pasien dengan jerawat ringan (0,52 ± 0,239 μmol/L) (p=0,000).