Giant splenic metastasis due to lung adenocarcinoma

Sánchez-Romero, Ana; Oliver, Israel; Costa, David J.; Orduña, Albina; Lacueva, Javier; Pérez-Vicente, Francisco; Arroyo, Antonio; Calpena, Rafael

doi:10.1007/bf02664942

Cited by 13 publications

(10 citation statements)

References 3 publications

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“…This finding is supported by several recently reported cases [3,4,12,13]. However in our patient, the primary lung cancer was in the right lung.…”

Section: Discussionsupporting

confidence: 92%

“…This is probably due to its high density of immune-system cells, its role in ''immune surveillance'' and its high concentration of angiogenesis inhibition factor [3,4]. However, isolated splenic metastasis is rarely reported.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, isolated splenic metastasis of primary lung cancer is exceedingly rare. To date, only 11 cases have been reported in published literature (table 1) [3,4,[6][7][8][9][10][11][12][13][14].…”

Section: Discussionmentioning

confidence: 99%

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Isolated splenic metastasis from lung cancer: ringleader of continuous fever

Tang¹,

Huang²,

Xiu³

et al. 2010

Eur Respir Rev

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The spleen is an infrequent metastatic organ of solid tumours, the prevalence of which ranges between 2.3% and 7.1% in populations with cancer as determined through autopsy. The most common sources of metastasis are breast, lung, colorectal and ovarian carcinoma and melanoma. Isolated metastasis of the spleen is rarely reported with only 93 cases from all sources having been reported up to 2007. Therefore, isolated splenic metastasis from primary lung cancer is exceedingly rare with only 11 cases reported to date.Herein, we report a rare case of isolated splenic metastasis in a 49-yr-old female 3 months after lobectomy for an undifferentiated large cell carcinoma in the right lung (pT 2a N 0 M 0 ). The only symptom the patient presented with was continuous high fever, which had never been previously reported. This patient presented diagnostic challenges due to the presentation of high fever, leukoapenia after chemotherapy and the cystic splenic mass, all of which led to the initial consideration of splenic abscess. The patient's high fever resolved rapidly after splenectomy and splenic metastasis was confirmed by pathological findings.We also reviewed all 11 reported previously cases and summarised the characteristics and appropriate management of isolated splenic metastasis from lung cancer.KEYWORDS: Fever, lung cancer, splenectomy, splenic metastasis ). Although the chemotherapy was thought to be responsible for myelosuppression and a secondary infection, no other symptoms existed to indicate the site of infection. The patient was admitted and treated with granulocyte colonystimulating factors and antibiotics. However, even though strong, broad spectrum anti-infection strategies were administered and the WBC recovered the patient's high fever was not resolved. Surprisingly, the abdominal ultrasonic inspection revealed a solid, cystic mass in the spleen 8.268.1 cm in size. A further abdominal CT scan also showed a 9.568.0 cm splenic mass with complex solid and cystic components ( fig. 1b). Splenic abscess was initially considered due to the manifestation of high fever only. However, percutaneous splenic puncture guided by ultrasound showed little fluid, which was cultured with no bacteria. Due to her history of lung cancer, splenic metastasis was considered; however, a chest CT

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“…This finding is supported by several recently reported cases [3,4,12,13]. However in our patient, the primary lung cancer was in the right lung.…”

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Isolated splenic metastasis from lung cancer: ringleader of continuous fever

Tang¹,

Huang²,

Xiu³

et al. 2010

Eur Respir Rev

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show abstract

“…Therefore, it was concluded at that time that spleen mass accompanying metastasis to other abdominal organs in patients with a known lung cancer should be regarded as a metastasis. We recently conducted a review of patients with lung cancer and spleen metastasis, and found 20 such patients (10)(11)(12)(13)(14)(15)17,(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30). In these 20 patients, it was notable that all but 4 of the 20 patients had no abdominal metastasis other than spleen metastasis.…”

Section: A B Cmentioning

confidence: 99%

Isolated spleen recurrence in a patient with lung adenocarcinoma: A case report

Iguchi

Ishibashi

Kondo

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. Spleen metastasis is extremely rare in patients with lung cancer. However, recent improvements in imaging modalities may enable the antemortem diagnosis of spleen metastasis. The present study reports the case of a female patient with lung adenocarcinoma and spleen metastasis. The patient developed isolated spleen metastasis in the postoperative course. This rare metastasis was detected in a follow-up abdominal computed tomography (CT) scan without any symptoms, and was confirmed by fluorodeoxyglucose positron emission tomography (FDG-PET)/CT scan. Although very rare, chest physicians and thoracic surgeons should be alert to the possibility of spleen metastasis development when evaluating the follow-up abdominal CT scan. FDG-PET/CT scanning and an interventional approach should be considered to clarify the possibility of spleen metastasis.

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“…6 Dalak arterin keskin bir açile dallanması, dalağın doğal ritmik kontraktil yapısı, afferent lenfatik yolağın olmaması, anjiyogenezi inhibe eden faktörlerin yüksek konsantrasyonu ve yoğun lenfoid doku nedeni ile tümör embolilerin solid dokuya ulaşmasının zorlaşması gibi birtakım mekanizmalar ile metastaza karşı direnç açıklan-maya çalışılmıştır. 7,8 Literatürde çoğunlukla bulunan olgu sunumları dışında yapılan klinik patolojik çalışmalar (cerrahi veya otopsi serileri) ile metastaza karşı direnç açıklanmaya çalışılmıştır. Yaygın hastalığa sahip olanlarda, splenik rüptür ya da hipersplenizm dışında tedavi yaklaşımı primer tümö-rün tedavisi şeklinde olmaktadır.…”

Section: E Funclassified

Splenic Metastasis in Lung Cancer

Kızılgöz¹,

Kabalak²,

Cengiz³

et al. 2017

Turkiye Klinikleri Arch Lung

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alak metastazı, nadir görülen ve genellikle yaygın hastalık ile ilişkili bir metastaz şeklidir. Diğer organlar ile karşılaştırıldığında anatomik, fizyolojik ve lenfoid yapısı nedeni ile metastazlara karşı daha dirençlidir. Meme, over, kolorektal sistem, akciğer ve malign melanoma dalak metastazı en sık görülen primer tümörlerdir.1 Tüm organ maligniteleri içinde dalak metastazı görülme sıklığı %2,3 ile 7,1 oranında saptanmaktadır.2 Sıklıkla asemptomatik olmakla birlikte, genel malignite semptomlarına ek olarak; lezyon boyutlarına göre karın ağrısı, hipersplenizm (anemi, trombositopeni) ve splenik rüptür gelişebilmektedir. 3Bu çalışmada, sıklığının az ve asemptomatik olması nedeni ile kliniği-mizde akciğer karsinomu tanısı alıp, dalak metastazı saptanan üç olgumuzun literatür eşliğinde sunulması amaçlanmıştır. OLGU SUNUMLARI OLGU 1Altmış bir yaşındaki erkek olgu, göğüs ağrısı nedeni ile kliniğimize baş-vurdu. Direkt akciğer grafisinde sağ hiler genişleme ve sağ orta zon, subpTurkiye Klinikleri Arch Lung 2017;18(2): [47][48][49][50][51] 47

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Giant splenic metastasis due to lung adenocarcinoma

Cited by 13 publications

References 3 publications

Isolated splenic metastasis from lung cancer: ringleader of continuous fever

Isolated splenic metastasis from lung cancer: ringleader of continuous fever

Isolated spleen recurrence in a patient with lung adenocarcinoma: A case report

Splenic Metastasis in Lung Cancer

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