Gibberellic acid, a plant growth regulator, increases mast cell recruitment and alters Substance P levels

Erin, Nuray; Afacan, Berna; Ersoy, Yasemin; Ercan, Feríha; Balcı, Mustafa Kemal

doi:10.1016/j.tox.2008.09.020

Cited by 34 publications

(22 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The reduction in the renal GSH level has been observed in adult rats in response to oxidative stress caused by GA 3 treatment [9]. Increased oxidative stress might be due to the enhanced inflammatory response evoked by GA 3 since it was previously shown that GA 3 increased mast cell degranulation and substance P levels [21].…”

Section: Discussionmentioning

confidence: 96%

Oxidative stress induced by gibberellic acid on kidney tissue of female rats and their progeny: biochemical and histopathological studies

et al. 2011

View full text Add to dashboard Cite

Gibberellic acid (GA(3)) is an endogenous plant growth regulator used worldwide in agriculture. The objective of this study was to investigate the effects of GA(3) on the kidney function of adult rats and their pups. Female Wistar rats were given daily 200 ppm GA(3) in drinking water from the 14th day of pregnancy until day 14 after delivery. GA(3) induced nephrotoxicity, as evidenced by a reduction in the 24-h urine volume and an increase in plasma creatinine, urea and uric acid levels. Nephrotoxicity was objectified by a significant increase of malondialdehyde level and a decrease of antioxidant enzyme activities like catalase, superoxide dismutase, glutathione peroxidase and glutathione content in kidneys of suckling pups and their mothers. Kidney histological studies confirmed biochemical parameters. We concluded that the exposure of rats to GA(3) induced oxidative stress and histopathological changes in kidneys of suckling rats and their mothers during late pregnancy and early postnatal periods.

show abstract

Section: Discussionmentioning

confidence: 96%

Oxidative stress induced by gibberellic acid on kidney tissue of female rats and their progeny: biochemical and histopathological studies

et al. 2011

View full text Add to dashboard Cite

show abstract

“…It could exert toxic effects on many soft organs including the liver . Furthermore, several studies demonstrated that, the chronic consumption of GA 3 increased tumor formation and oxidative stress (Erin et al 2008). Alternatively, indole-3-acetic acid (IAA) is the most abundant naturally occurring auxin, well known for its regulatory function in plant growth (Rapparini et al 2002).…”

Section: Introductionmentioning

confidence: 99%

Proanthocyanidin as a cytogenetic protective agent against adverse effects of plant growth regulators supplementation in rats

2013

View full text Add to dashboard Cite

The aim of the present study was to investigate the protective role of grape seed extract (containing proanthocyandin) against the adverse effects of plant growth regulators (GA 3 (gibberellic acid) and IAA (indoleacetic acid)). The present data showed that the administration of either GA 3 and IAA caused undesirable changes in both hepatic and testicular structure. This was evidenced by a disturbed hepatic strands, pyknotic nuclei, central vein with collapsed endothelium, dilatation in bile sinusoids, congested blood vessel, binucleatd hepatocytes, lymphocytic infiltration, vacuolation, giant hepatic cells, increased Kupffer cells and karyoryxis. Additionally, it was shown that degenerative changes in the testis, spermatogenic arrest, moderate tubular necrosis, Leydig cell degeneration and reduction in the number and size of the seminiferous tubules with some spermatogonia detached from the basement membrane. Concerning flow cytometric study of the liver a significant decrease in G0/1 % and a significant increase in S phase %, G2/ M %, P 53 % and apoptosis % (sub G1) were detected. However, in testis the data recorded a significant decrease in the percentage of mature sperm (percentage of haploid cells) and a significant increase in the percentage of spermatide, diploid cells, P 53 and of apoptotic cells. On the other hand, a distinct recovery of the mentioned hepatic and testicular histopathological and cytogenetic disorders was observed when proanthocyanidin was supplemented to rats administered either of the plant growth hormones (GA 3 and IAA).

show abstract

“…Each rat was given 1 ml of the prepared solution daily. (3) Group III (the GA3-treated group): This group received GA3 at a dose of 20 mg/kg daily orally through a gastric tube [18]. The calculated dose was obtained by dissolving 400 mg of GA3 in 100 ml of distilled water.…”

Section: Resultsmentioning

confidence: 99%

“…Little is known about the toxic effects of GA3 in mammals as well as its potential hazardous effects on human health [18]. Liver is one of the main target organs for different xenobiotics.…”

Section: Electron Microscopymentioning

confidence: 99%

Histological and immunohistochemical study on the effect of gibberellic acid on the liver of adult male albino rats and the possible protective role of green tea

Tawfik¹

2015

The Egyptian Journal of Histology

View full text Add to dashboard Cite

Gibberellic acid, a plant growth regulator, increases mast cell recruitment and alters Substance P levels

Cited by 34 publications

References 48 publications

Oxidative stress induced by gibberellic acid on kidney tissue of female rats and their progeny: biochemical and histopathological studies

Oxidative stress induced by gibberellic acid on kidney tissue of female rats and their progeny: biochemical and histopathological studies

Proanthocyanidin as a cytogenetic protective agent against adverse effects of plant growth regulators supplementation in rats

Histological and immunohistochemical study on the effect of gibberellic acid on the liver of adult male albino rats and the possible protective role of green tea

Contact Info

Product

Resources

About