Gibt es Entzugserscheinungen nach kurzfristigem Schlafmittelgebrauch bei Gesunden?

Maxion, H; Schneider, Elke; Jacobi, Pedro Roberto

doi:10.1055/s-0028-1094286

Cited by 3 publications

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“…Bar biturates lead to a typical deprivation of REMsleep accompanied with rebound phenomena, especially after withdrawal (Oswald et al, 1963(Oswald et al, , 1967Maxion et aL, 1970). Comparable effects could be found after application of primidon widely used as an antiepileptic drug, moreover characterized by a so-called matitudinal 'hangover', which we could not observe in our subjects treated with DPA.…”

Section: Discussionmentioning

confidence: 46%

Gamma-Aminobutyric Acid (GABA) and Sleep

Schneider¹,

Ziegler²,

Maxion³

1977

Eur Neurol

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The effects of di-n-propylacetic acid (DPA) on sleep, for some years used as an anticonvulsive drug, has been investigated in 11 healthy volunteers using all-night sleep EEG recordings. DPA acts by an enhancement of the gamma-aminobutyric acid (GABA) level of the brain. Its influence on sleep seemed to be of interest on account of the metabolic relationship of GABA to other short chain fatty acids. After short-term application only a shortening of the time to fall asleep and of the waking time could be found, whereas under long-term administration a decrease in deep synchronous sleep could be observed. In contrast to the results known from animal studies no marked influence on REM sleep was observed. The action of DPA on sleep is similar to that of diphenylhydantoin. No so-called matitudinal ‘hangover’ could be revealed in either drug.

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Section: Discussionmentioning

confidence: 46%

Gamma-Aminobutyric Acid (GABA) and Sleep

Schneider¹,

Ziegler²,

Maxion³

1977

Eur Neurol

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Solid‐state polymerization of poly(ethylene terephthalate)

Chang

Sheu

Chen

1983

J of Applied Polymer Sci

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Solid-state low molecular temperature. Synopsispolymerization of poly(ethy1ene terephthalate) (PET) is carried out by heating the weight prepolymer at temperatures below its melting point but above its glass transition Postcondensation occurs and the condensation byproducts can be removed by applying vacuum or inert gas. Polymers obtained usually have high molecular weight, low carboxyl and acetaldehyde content, and can be used for beverage bottle or industrial yarns. Polyesters for textile purposes are manufactured by a melt process. Chemical reactions involved in the solid state polymerization are transesterification, esterification, as well as the diffusion of byproducts. Overall reaction rate was governed by the molecular weight, carboxyl content of prepolymer, crystallinity, particle size, reaction temperature, and time. Prepolymer for solid state polymerization should have intrinsic viscosity 0.4 dL/g or more, density 1.38 g/mL, and minimum dimension 3 mm or less. The reaction temperature could be 200-250OC. When textile grade PET is used as prepolymer, crystallization at 180-190°C for 1-2 b increases the density to 1.38 g/mL. Polymerization at 240-245°C for 3-5 h can raise the intrinsic viscosity to 0.72 dL/g and carboxyl content less than 20 meqkg. Appropriate reaction conditions are subject to the properties of prepolymers and the'design of reactors. Reactor used for solid state polymerization could be vacuum dryer type or stationary bed. The former is suitable for a small capacity and is run batchwise. The latter is a continuous process and is economically feasible for large-scale production.

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Alkoholdelir und Traumschlaf

Maxion

Schneider

1971

Arch. Psychiat. Nervenkr.

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Gibt es Entzugserscheinungen nach kurzfristigem Schlafmittelgebrauch bei Gesunden?

Cited by 3 publications

References 0 publications

Gamma-Aminobutyric Acid (GABA) and Sleep

Gamma-Aminobutyric Acid (GABA) and Sleep

Solid‐state polymerization of poly(ethylene terephthalate)

Alkoholdelir und Traumschlaf

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