Gingival metastasis of a bronchogenic adenocarcinoma: report of a case

Cancer is a disease involving complex multiple sequential irreversible dysregulated processes showing metastasis that results in morbidity and mortality. Metastasis is a complex biological course that begins with detachment of tumor cells from the primary tumor, spreading into the distant tissues and/or organs, invading through the lymphovascular structures followed by their survival in the circulation. Metastatic tumors to the oro-facial region are uncommon and may occur in the oral soft tissues or jawbones. The clinical presentation of metastatic tumors can be variable, which may lead to erroneous diagnosis or may create diagnostic dilemma. Therefore, they should be considered in the differential diagnosis of inflammatory and reactive lesions that are common to the oral region. Most of the literature on oral metastases involves either single case reports or reviews of these reported cases from scattered geographical areas. Hence this present article is an attempt to provide a detailed review of pathogenesis, epidemiological details including clinical and radiographic presentations, microscopic features and treatment of metastatic tumors to the jaws and oral cavity.

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“…[2122] Gingival metastases are shown to be polypoid or exophytic, highly vascularized, and hemorrhagic. [23]…”

Section: Pathogenesismentioning

confidence: 99%

Metastatic tumors to the jaws and oral cavity

Kumar

Manjunatha

2013

J Oral Maxillofac Pathol

127

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“…Although any site may be affected, metastasis to soft tissues is much rarer, with the most common site being the gingiva (55%), followed by the tongue site (30%). To a large extent, the predilection for gingiva is lost after teeth are extracted [7,11]. The possible role of inflammation in attracting metastatic cells towards the attached gingiva has been suggested [3].…”

Section: Discussionmentioning

confidence: 99%

Metastatic Adenocarcinoma of the Colon: Early Manifestation in Gingival Tissue

Soares¹,

Thomaz²,

Duarte³

et al. 2010

Head and Neck Pathol

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A case of gingival metastasis of adenocarcinoma of the colon is reported, the lesion being an early clinical indication of a primary malignant tumor. The diagnosis of metastatic lesion in the oral region is always challenging, both to clinician and to the pathologist, due to its rarity and complexity. In the present case, the clinical hypothesis was peripheral ossifying fibroma or pyogenic granuloma. Histologically, the biopsy tissue revealed a malignant neoplasm not connected to the mucosal surface. Immunohistochemically, the lesion was positive for 35ßH11 and cytokeratin 20 and focally positive for cytokeratin 7. Treatment involved excision of primary tumor and follow-up chemotherapy. The clinical, histological and immunohistochemical characteristics are discussed.

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“…This distant spread indicates that cancer cells may reach several sites throughout the body via the bloodstream and the lymphatic system (1,2). Similar to other malignant diseases, oral metastasis from lung cancer reflects the progression of the primary malignancy, and the majority of such patients present with multiple metastatic sites (3,4). Recently, however, some researchers reported patients with no metastasis other than to the oral cavity (5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Non-small-cell lung cancer metastasis to the oral cavity: A case report

Ito

Onizawa

Satoh

2017

Molecular and Clinical Oncology

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Abstract. We herein report an unusual occurrence of lung cancer metastasis to the oral cavity, reflecting the progression of the primary malignancy. A biopsy of oral lesions should always be performed, even of those located in uncommon sites, in patients with a history of uncontrolled lung cancer. Although this is a rare occurrence, our patient exhibited characteristics suggestive of oral metastasis from lung cancer, namely presence of lung adenocarcinoma, development of oral metastasis during the clinical course of the disease, accompanying multiple metastatic lesions, including to the brain and abdomen, and rapid fatal progression after the manifestation of oral metastasis. It is important to acknowledge the possibility of metastasis to the oral cavity in lung cancer patients with extensive metastases. Prompt diagnosis by biopsy of the lesion is required to establish the correct diagnosis.

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Gingival metastasis of a bronchogenic adenocarcinoma: report of a case

Cited by 26 publications

References 21 publications

Metastatic tumors to the jaws and oral cavity

Metastatic tumors to the jaws and oral cavity

Metastatic Adenocarcinoma of the Colon: Early Manifestation in Gingival Tissue

Non-small-cell lung cancer metastasis to the oral cavity: A case report

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