Gingival Primary Extranodal Non‐Hodgkin's Lymphoma as the First Manifestation of Acquired Immunodeficiency Syndrome

Navarro, Cláudia Maria; Shibli, Jamil Awad; Ferrari, Roberto B.; d'Avila, Susana; Sposto, M. R.

doi:10.1902/jop.2008.070229

Cited by 12 publications

(7 citation statements)

References 16 publications

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“…NHL of the oral cavity and oropharynx is defined as either B-or natural killer (NK)/T-lymphoid cell cancer. Bone involvement also occurs in some rare cases (3). Oral lesions most frequently present as painless erythematous enlargements that may become ulcerated and hemorrhagic because of traumatic injury.…”

Section: Introductionmentioning

confidence: 99%

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Diagnosis, PET/CT imaging, and treatment of extranodal non-Hodgkin lymphoma in keratinized gingiva: a case report

et al. 2015

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Section: Introductionmentioning

confidence: 99%

“…Immunohistochemical examination and novel imaging methods such as positron emission tomography/ computed tomography (PET/CT) have been shown to enable successful diagnosis and management of NHL (3,4). However, the application of PET/CT has not been reported for clinical diagnosis of primary NHL in the gingiva.…”

Section: Introductionmentioning

confidence: 99%

Diagnosis, PET/CT imaging, and treatment of extranodal non-Hodgkin lymphoma in keratinized gingiva: a case report

et al. 2015

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“…Most of the extranodal NHLs of the head and neck arise in the Waldeyer's ring followed by salivary glands, particularly the parotid gland, 3,5 and in the oral cavity in 2.5% of cases 5 . The gingiva is one of the rarest intraoral sites involved with PE NHL 6‐8 . An increase in the prevalence of NHL in immunocompromised patients has long been recognized 9,10 .…”

Section: Introductionmentioning

confidence: 99%

“…5 The gingiva is one of the rarest intraoral sites involved with PE NHL. [6][7][8] An increase in the prevalence of NHL in immunocompromised patients has long been recognized. 9,10 Moreover, the majority of the oral NHLs described in the literature are of diffuse large Bcell lymphoma.…”

Section: Introductionmentioning

confidence: 99%

Primary Non‐Hodgkin Lymphoma of Palatal Gingiva

Sharma

Yadav

Kataria

et al. 2012

Clin Adv Periodontics

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Introduction: Non‐Hodgkin lymphomas (NHLs) are a heterogeneous group of lymphoproliferative malignancies that can disseminate to organs and tissues that do not ordinarily contain lymphoid cells (extranodal sites). Primary extranodal NHL of the oral cavity is rare, and gingiva is one of the rarest intraoral sites involved. The majority of oral NHLs reported are of diffuse large B‐cell type. Such lymphomas are more prevalent in immunocompromised patients. Because of their malignant nature, early recognition, diagnosis, and treatment are essential for a patient's survival. To the best of our knowledge, this report presents the first case of diffuse mixed small and large B‐cell lymphoma involving the gingiva in a non‐immunocompromised patient. Case Presentation: A female patient presented with a growth located on the palatal aspect of the right maxillary molar region involving marginal and interdental gingiva. Routine laboratory tests and clinical examination were within normal limits. An incisional biopsy of the gingival tissue was evaluated using histologic techniques and immunohistochemistry. A diagnosis of extranodal diffuse mixed small and large B‐cell lymphoma was established. The patient underwent a complete workup to rule out other systemic lesions, thereby supporting the primary nature of the lesion. Conclusion: Gingival overgrowth may rarely be the first manifestation of extranodal NHL. Only histopathological examination of the specimen with immunohistochemistry can ascertain a confirmed diagnosis of NHL. The present case report stresses the importance of routine biopsy examination for growth lesions of long duration when an infectious etiology has been ruled out, even if the lesions appear benign.

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“…There is an increasing incidence of NHL in patients with autoimmune disease, including coeliac disease, immune suppression from HIV, rheumatoid arthritis and Sjögren’s syndrome 3 . Diagnosis of NHL in the oral cavity may result from mucosal tissue or gingival swelling, or masses 4 . When major salivary glands are involved, they are commonly the first area of clinical manifestation of disease, and disease is often confined to the salivary glands.…”

Section: Introductionmentioning

confidence: 99%

T‐cell lymphoma of the oral cavity: a case report

Villa

Mariani

Villa

2010

Australian Dental Journal

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Lymphomas are defined as heterogeneous malignancies of the lymphatic system characterized by a proliferation of lymphoid cells or their precursors. Malignant lymphoma of the oral cavity has been described previously although reports on the occurrence of intraoral extranodal T-cell lymphomas are scarce. Oral lesions may appear as a painless enlargement, erythematous, often with surface ulceration secondary to trauma. This is a report of a rare case in which a specific subtype of T-cell lymphoma appeared in the oral cavity.

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Gingival Primary Extranodal Non‐Hodgkin's Lymphoma as the First Manifestation of Acquired Immunodeficiency Syndrome

Abstract: The present case reports have important clinical implications; the two unusual presentations of gingival PE-NHL contribute to information about the differential diagnosis of rapidly progressing gingival swelling.

Cited by 12 publications

References 16 publications

Diagnosis, PET/CT imaging, and treatment of extranodal non-Hodgkin lymphoma in keratinized gingiva: a case report

Diagnosis, PET/CT imaging, and treatment of extranodal non-Hodgkin lymphoma in keratinized gingiva: a case report

Primary Non‐Hodgkin Lymphoma of Palatal Gingiva

T‐cell lymphoma of the oral cavity: a case report

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