Ginkgolide B Reduces the Degradation of Membrane Phospholipids to Prevent Ischemia/Reperfusion Myocardial Injury in Rats

Pei, Hong; Hua, Rong; Guan, Cha Xiang; Fang, Xiang

doi:10.1159/000438945

Cited by 20 publications

(24 citation statements)

References 24 publications

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“…Ginkgolide B (GB) is a primary active monomer of ginkgolide that inhibits the activity of platelet-activating factor (PAF) by binding to its membrane receptor ( 15 ). BN 52021 has a protective effect against myocardial ischemia/reperfusion (IR) dysfunction ( 16 ), cerebral ischemic damage and the neurological deficits of mice after middle cerebral artery occlusion (MCAO) ( 17 ). GB also efficiently alleviates spinal cord injury by inhibiting STAT1 expression ( 18 ) and protects human umbilical vein endothelial cells via pregnane X receptor activation ( 19 ).…”

Section: Introductionmentioning

confidence: 99%

Comparing the role of Ginkgolide B and Ginkgolide K on cultured astrocytes exposed to oxygen‑glucose deprivation

Cao²,

Zhao

et al. 2018

Mol Med Report

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Ginkgolide B (GB) and ginkgolide K (GK) are two main active monomers of ginkgolides that present a unique group of diterpenes found naturally in the leaves of the Ginkgo biloba tree. Astrocytes are the most abundant cell type within the central nervous system (CNS) and serve essential roles in maintaining healthy brain function. The present study compared the biological effects of GB and GK on astrocytes exposed to oxygen-glucose deprivation (OGD). The results demonstrated that GB and GK exhibit many different actions. The level of the platelet-activating factor (PAF) was elevated on astrocytes exposed to OGD, and inhibited by GB and GK treatment. Although GB and GK inhibited the expression of p-NF-κB/p65, GK exerted stronger anti-inflammatory and antioxidant effects on astrocytes exposed to OGD than GB by inhibiting interleukin (IL)-6 and tumor necrosis factor-α, and inducing IL-10 and the nuclear factor-erythroid 2-related factor 2/HO-1 signaling pathway. When compared with GB treatment, GK treatment maintained high levels of phosphoinositide 3-kinase/phosphorylated-protein kinase B expression, and induced a marked upregulation of Wnt family member 1 and brain derived neurotrophic factor, indicating that GK, as a natural plant compound, may have more attractive prospects for clinical application in the treatment of neurological disorders than GB.

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Section: Introductionmentioning

confidence: 99%

Comparing the role of Ginkgolide B and Ginkgolide K on cultured astrocytes exposed to oxygen‑glucose deprivation

Cao²,

Zhao

et al. 2018

Mol Med Report

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“…Ginko biloba has been widely used for the treatments of ischemic stroke and nerve system diseases . In recent study of Huang et al, the authors also inferred that Ginko biloba could promote hair growth in model mice .…”

Section: Discussionmentioning

confidence: 99%

“…Ginkgo biloba is a widely used traditional medicine for treatments of ischemic stroke and nerve system diseases . Previous study showed that the administration of Ginkgo biloba extract dramatically increased vascular endothelial growth factor (VEGF) production and improved hair growth in C57 mice .…”

Section: Introductionmentioning

confidence: 99%

“…Ginkgo biloba is a widely used traditional medicine for treatments of ischemic stroke and nerve system diseases. [13][14][15] Previous study showed that the administration of Ginkgo biloba extract dramatically increased vascular endothelial growth factor (VEGF) production and improved hair growth in C57 mice. 16 Therefore, it was reasonable to further explore the major functional components and mechanism driving the effect of Ginkgo biloba extract.…”

Section: Introductionmentioning

confidence: 99%

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Ginkgolide B and bilobalide promote the growth and increase β‐catenin expression in hair follicle dermal papilla cells of American minks

et al. 2019

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The regeneration of proliferation potential of dermal papilla (DP) cells contributes to the treatment of hair loss disorders. Ginkgolide B (GKB) and bilobalide (BB) are two functional components isolated from Ginkgo biloba that can promote hair growth. In the current study, the effect of GKB or BB on DP cell viability and the related signaling was assessed. Hair follicles were isolated from minks, and the growth of hair follicles was measured under the administration of GKB or BB. DP cells isolated from minks were also subjected to GKB or BB. The administration of GKB or BB induced the growth of hair follicles. The viability of DP cells was also increased by GKB or BB as illustrated by methyl thiazolyl tetrazolium and flow cytometry detection. Moreover, the secretion of VEGF was enhanced by GKB or BB. At molecular level, the activities of Akt, ERK1/2, and β‐catenin were induced by GKB, whereas BB only increased the activities of Akt and β‐catenin. In conclusion, although the two components influenced the β‐catenin signaling activity in distinct mechanisms, they both increased the viability of DP cells and promoted the cycle of hair follicles.

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“…Furthermore, PAF has been reported to play an important role in many pathophysiological processes including cerebral edema and cerebral ischemia-reperfusion injury through interactions with PAFR1718. PAFR, which belongs to G protein coupled receptors superfamily, is a seven transmembrane proteins that expressed extensively throughout the brain including microglia and neurons and has been reported to be activated by interating with PAF1920. To determine the relationship between PAF and the inflammatory response after TBI, we explored development of inflammation in the brain of PAFR knockout in which the effects had on cognitive function.…”

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confidence: 99%

Loss of PAFR prevents neuroinflammation and brain dysfunction after traumatic brain injury

Yin

Chen

Zhu

et al. 2017

Sci Rep

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Traumatic brain injury (TBI) is a principal cause of death and disability worldwide, which is a major public health problem. Death caused by TBI accounts for a third of all damage related illnesses, which 75% TBI occurred in low and middle income countries. With the increasing use of motor vehicles, the incidence of TBI has been at a high level. The abnormal brain functions of TBI patients often show the acute and long-term neurological dysfunction, which mainly associated with the pathological process of malignant brain edema and neuroinflammation in the brain. Owing to the neuroinflammation lasts for months or even years after TBI, which is a pivotal causative factor that give rise to neurodegenerative disease at late stage of TBI. Studies have shown that platelet activating factor (PAF) inducing inflammatory reaction after TBI could not be ignored. The morphological and behavioral abnormalities after TBI in wild type mice are rescued by general knockout of PAFR gene that neuroinflammation responses and cognitive ability are improved. Our results thus define a key inflammatory molecule PAF that participates in the neuroinflammation and helps bring about cerebral dysfunction during the TBI acute phase.

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Ginkgolide B Reduces the Degradation of Membrane Phospholipids to Prevent Ischemia/Reperfusion Myocardial Injury in Rats

Cited by 20 publications

References 24 publications

Comparing the role of Ginkgolide B and Ginkgolide K on cultured astrocytes exposed to oxygen‑glucose deprivation

Comparing the role of Ginkgolide B and Ginkgolide K on cultured astrocytes exposed to oxygen‑glucose deprivation

Ginkgolide B and bilobalide promote the growth and increase β‐catenin expression in hair follicle dermal papilla cells of American minks

Loss of PAFR prevents neuroinflammation and brain dysfunction after traumatic brain injury

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