Ginseng, the Root of Panax ginseng C.A. Meyer, Protects Ethanol-Induced Gastric Damages in Rat through the Induction of Cytoprotective Heat-Shock Protein 27

Yeo, Myoung-Souk; Kim, Dong Kyu; Cho, Sung Won; Hong, Hee Do

doi:10.1007/s10620-007-9946-6

Cited by 36 publications

(27 citation statements)

References 33 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These low levels of expression likely indicate an important role for HSP27 in cellular homeostasis and gastric mucosa defense (33)(34)(35)(36). In accordance with previous results, we also found HSP27 expressed in majority of gastric mucosa.…”

Section: Discussionmentioning

confidence: 99%

Heat shock protein 27 is over-expressed in tumor tissues and increased in sera of patients with gastric adenocarcinoma

Huang¹,

Ye²,

Huang

et al. 2009

Clinical Chemistry and Laboratory Medicine

View full text Add to dashboard Cite

Background: In a previous study, we found that heat shock protein 27 (HSP27) was over-expressed in gastric adenocarcinoma (GA) tissue. In this study, our goal was to further verify the expression profile of HSP27 in patients with GA. Methods: Western blot and immunohistochemistry were employed to determine HSP27 expression in 50 paired tumor and adjacent normal tissue. ELISA was used to quantify serum HSP27 concentrations in the same 50 GA patients and 50 healthy individuals. Results: Compared to adjacent normal tissues, HSP27 was over-expressed in 25 (50%, ps0.000) and 24 (48%, ps 0.000) cases of GA tissue by Western blot and immunohistochemistry, respectively. ELISA revealed significantly higher serum concentrations of HSP27 in patients with GA patients (means986 pg/mL) compared to healthy individuals (means573 pg/mL) (ps0.003). In addition, infection with Helicobacter pylori (HP) in healthy individuals was associated with increased expression of HSP27 in both gastric mucosa and serum. Conclusions: These data suggest that HSP27 is overexpressed in GA tissue and serum concentrations of HSP27 are increased in patients with GA. Over-expression of HSP27 may indicate a gastric malignant/infectious process. The detection of serum HSP27 concentrations by ELISA may be useful for screening for GA. Clin Chem Lab Med 2010;48:263-9.

show abstract

Section: Discussionmentioning

confidence: 99%

Heat shock protein 27 is over-expressed in tumor tissues and increased in sera of patients with gastric adenocarcinoma

Huang¹,

Ye²,

Huang

et al. 2009

Clinical Chemistry and Laboratory Medicine

View full text Add to dashboard Cite

show abstract

“…Moreover, ginseng had protective effects from alcohol-induced gastric damages in rats. Significant induction of cytoprotective heat-shock proteins HSP27 and HSP70 was found in the ginseng-administrated rats, which suggested that the restoration of these proteins might contribute to preventing alcohol-induced gastric injuries [96]. Therefore, red ginseng could be used as potential treatment of hangover and alcohol-induced reproductive and gastric toxicity due to its antioxidant activity.…”

Section: Panax Ginsengmentioning

confidence: 99%

“…Mice Amelioration of liver and brain alcohol injuries through decreasing L-γ-glutamyl transpeptidase and butyryl cholinesterase [76] Humans Decreased signs and symptoms of alcohol hangover [79] Essential oil and citral Mice Hepatoprotective property against AFLD by decreasing levels of D-glucurono-6,3-lactone, glycerol-3-phosphate, and pyruvic acid in serum [80] Opuntia ficus-indica Flavones and phenolics Cladode Humans Reduced hangover symptoms by inflammatory mediator production inhibition [88,89] Rats Suppression of liver damage induced by alcohol through ending free radical chain reactions or enhancing the endogenous antioxidant activities [90] Panax ginseng Ginsenosides Root Humans Relief from hangover symptoms through reduced expiratory and plasma alcohol levels and hangover severity [91] Linoleic acid Mice Alleviation of hangover through reduced alcohol and acetaldehyde levels and enhanced ADH and ALDH activities [92] Mice Suppressed alcohol-induced toxicity on male fertility [93] Ricefish Suppressed alcohol-induced toxicity on embryogenesis [94] Mouse embryos Suppressed alcohol-induced toxicity in the neurocranium through its effects on antioxidant activity [95] Rats Suppressed alcohol-induced toxicity in the gastric system via the restoration of heat-shock proteins [96] Hypericum perforatum Hypericin and hyperforin Leave and flowering tops Rats and mice Reduced voluntary alcohol intake in acute and chronic alcohol treatment through neurochemical mechanisms [101,104,105] Rats Attenuated alcohol withdrawal syndrome by inhibition of the effects on tremors and audiogenic seizures [102] Salvia miltiorrhiza…”

Section: -Gingerol Rhizomementioning

confidence: 99%

Natural Products for the Prevention and Treatment of Hangover and Alcohol Use Disorder

Wang

Zhang

et al. 2016

Molecules

View full text Add to dashboard Cite

Alcoholic beverages such as beer, wine and spirits are widely consumed around the world. However, alcohol and its metabolite acetaldehyde are toxic and harmful to human beings. Chronic alcohol use disorder or occasional binge drinking can cause a wide range of health problems, such as hangover, liver damage and cancer. Some natural products such as traditional herbs, fruits, and vegetables might be potential dietary supplements or medicinal products for the prevention and treatment of the problems caused by excessive alcohol consumption. The aim of this review is to provide an overview of effective natural products for the prevention and treatment of hangover and alcohol use disorder, and special emphasis is paid to the possible functional component(s) and related mechanism(s) of action.

show abstract

“…Extracts of T. wilfordii have been used as a traditional herbal therapy in Chinese medicine to treat different illnesses, but recent results have suggested that celastrol could be a potential agent to treat diseases such as Alzheimer disease (Chow et al 2013;Allison et al 2001). A study on the potential cytoprotective effect of ginseng indicated that pretreatment with ginseng prevented the ethanol-induced gastric lesions and decreased the level of apoptotic cell death in the rat gastric mucosa (Yeo et al 2008). Moreover, Hsp27 and Hsp70 were found to be overexpressed in ginseng-pretreated rats.…”

Section: Possible Mechanism Of Hsp Protection and Potential Therapeutmentioning

confidence: 99%

Alcohol stress, membranes, and chaperones

Tóth

Vı́gh

Sántha

2014

Cell Stress and Chaperones

View full text Add to dashboard Cite

Ethanol, which affects all body organs, exerts a number of cytotoxic effects, most of them independent of cell type. Ethanol treatment leads to increased membrane fluidity and to changes in membrane protein composition. It can also interact directly with membrane proteins, causing conformational changes and thereby influencing their function. The cytotoxic action may include an increased level of oxidative stress. Heat shock protein molecular chaperones are ubiquitously expressed evolutionarily conserved proteins which serve as critical regulators of cellular homeostasis. Heat shock proteins can be induced by various forms of stresses such as elevated temperature, alcohol treatment, or ischemia, and they are also upregulated in certain pathological conditions. As heat shock and ethanol stress provoke similar responses, it is likely that heat shock protein activation also has a role in the protection of membranes and other cellular components during alcohol stress.

show abstract

Ginseng, the Root of Panax ginseng C.A. Meyer, Protects Ethanol-Induced Gastric Damages in Rat through the Induction of Cytoprotective Heat-Shock Protein 27

Cited by 36 publications

References 33 publications

Heat shock protein 27 is over-expressed in tumor tissues and increased in sera of patients with gastric adenocarcinoma

Heat shock protein 27 is over-expressed in tumor tissues and increased in sera of patients with gastric adenocarcinoma

Natural Products for the Prevention and Treatment of Hangover and Alcohol Use Disorder

Alcohol stress, membranes, and chaperones

Contact Info

Product

Resources

About