Ginsenoside Rh2 inhibits breast cancer cell growth via&amp;lt;?A3B2 ACK?&amp;gt;ER&amp;beta;-TNF&amp;alpha; pathway

Peng, Kunjian; Luo, Tiao; Li, Jijia; Huang, Jingjia; Dong, Zizeng; Liu, Jia; Pi, Chaoqiong; Zou, Zizeng; Gu, Qin; Liu, Ousheng; Zhang, Jian-Ting; Luo, Zhitian

doi:10.3724/abbs.2022039

Cited by 13 publications

(9 citation statements)

References 51 publications

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“…Furthermore, in our study the content of minor ginsenoside Rh 2 in the SLPN-instant beverage was 1.64 ± 0.14 mg/g-DW, being five times higher than that in SLPN. G-Rh 2 could inhibit colorectal cancer cell growth ( 56 ), suppress the proliferation of A549 cells ( 57 ), breast cancer cell growth ( 58 ), and moreover the combination of G-Rh 2 could induce lung cancer ( 59 ). Up to date, G-Rh 2 is being developed as a new antitumor drug.…”

Section: Discussionmentioning

confidence: 99%

An instant beverage rich in nutrients and secondary metabolites manufactured from stems and leaves of Panax notoginseng

Liang

Liu²,

Li³

et al. 2022

Front. Nutr.

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IntroductionRadix Notoginseng, one of the most famous Chinese traditional medicines, is the dried root of Panax notoginseng (Araliaceae). Stems and leaves of P. notoginseng (SLPN) are rich in secondary metabolites and nutrients, and authorized as a food resource, however, its utilization needs further research.MethodsA SLPN-instant beverage was manufactured from SLPN through optimization by response surface design with 21-fold of 48.50% ethanol for 39 h, and this extraction was repeated twice; the extraction solution was concentrated to 1/3 volume using a vacuum rotatory evaporator at 45°C, and then spray dried at 110°C. Nutritional components including 14 amino acids, ten mineral elements, 15 vitamins were detected in the SLPN-instant beverage; forty-three triterpenoid saponins, e.g., ginsenoside La, ginsenoside Rb3, notoginsenoside R1, and two flavonoid glycosides, as well as dencichine were identified by UPLC-MS.ResultsThe extraction rate of SLPN-instant beverage was 37.89 ± 0.02%. The majority nutrients were Gly (2.10 ± 0.63 mg/g), His (1.23 ± 0.07 mg/g), α-VE (18.89 ± 1.87 μg/g), β-VE (17.53 ± 1.98 μg/g), potassium (49.26 ± 2.70 mg/g), calcium (6.73 ± 0.27 mg/g). The total saponin of the SLPN-instant beverage was 403.05 ± 34.98 mg/g, majority was notoginsenoside Fd and with contents of 227 ± 2.02 mg/g. In addition, catechin and γ-aminobutyric acid were detected with levels of 24.57 ± 0.21 mg/g and 7.50 ± 1.85 mg/g, respectively. The SLPN-instant beverage showed good antioxidant activities with half maximal inhibitory concentration (IC50) for scavenging hydroxyl (OH–) radicals, superoxide anion (O2–) radicals, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonate) (ABTS+) radicals were 0.1954, 0.2314, 0.4083, and 0.3874 mg/mL, respectively.ConclusionWe optimized an analytical method for in depth analysis of the newly authorized food resource SLPN. Together, an instant beverage with antioxidant activity, rich in nutrients and secondary metabolites, was manufactured from SLPN, which may improve the utilization of SLPN.

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Section: Discussionmentioning

confidence: 99%

An instant beverage rich in nutrients and secondary metabolites manufactured from stems and leaves of Panax notoginseng

Liang

Liu²,

Li³

et al. 2022

Front. Nutr.

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“…45 Furthermore, Rh2 with moderate estrogenic activity could also promote TNF-α-induced apoptosis of MCF-1 cells and G1/S phase arrest by modulating ERβ. 46…”

Section: Estrogen-like Effects Of Ginsenosidesmentioning

confidence: 99%

Ginsenoside – a promising natural active ingredient with steroidal hormone activity

Li,

Zhao,

Wang

et al. 2024

Food Funct.

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“…Frontiers in Pharmacology frontiersin.org arrest by activating p38 and decreasing cyclin D1 expression (Peng et al, 2022). Moreover, ginsenoside Rh2 mediates G1 phase arrest of BC cells, which is caused by p15 INK4B and p27 kip1 dependent inhibition of CDKs/cyclin complex (Choi et al, 2009).…”

Section: Anti-breast Cancer Activity Of Ppd Typesmentioning

confidence: 99%

“…It is reported that ginsenoside Rh2 mediates cell cycle arrest and inhibits proliferation of BC cells ( Oh et al, 1999 ; Hu et al, 2021 ). Ginsenoside Rh2 can mediate G 1 /S cell cycle arrest by activating p38 and decreasing cyclin D1 expression ( Peng et al, 2022 ). Moreover, ginsenoside Rh2 mediates G1 phase arrest of BC cells, which is caused by p15 INK4B and p27 kip1 dependent inhibition of CDKs/cyclin complex ( Choi et al, 2009 ).…”

Section: Anti-breast Cancer Activity Of Ginsenosidesmentioning

confidence: 99%

“…It is reported that ginsenoside Rh2 can induce BC cells apoptosis ( Park et al, 2022 ). Studies have shown that ginsenoside Rh2 can increase the expression of TNFα (tumor necrosis factor α) by up-regulating ERβ (estrogen receptor β ), which in turn induces apoptosis of BC cells ( Peng et al, 2022 ). Furthermore, ginsenoside Rh2 induced apoptosis of BC cells was associated with increased levels of pro-apoptotic proteins including Bak, Bax and Bim, and decreased levels of anti-apoptotic proteins including Bcl-2, Bcl-xL and Mcl-1 ( Choi et al, 2011 ).…”

Section: Anti-breast Cancer Activity Of Ginsenosidesmentioning

confidence: 99%

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Anti-cancer effect and potential microRNAs targets of ginsenosides against breast cancer

et al. 2022

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Breast cancer (BC) is one of the most common malignant tumor, the incidence of which has increased worldwide in recent years. Ginsenosides are the main active components of Panax ginseng C. A. Mey., in vitro and in vivo studies have confirmed that ginsenosides have significant anti-cancer activity, including BC. It is reported that ginsenosides can induce BC cells apoptosis, inhibit BC cells proliferation, migration, invasion, as well as autophagy and angiogenesis, thereby suppress the procession of BC. In this review, the therapeutic effects and the molecular mechanisms of ginsenosides on BC will be summarized. And the combination strategy of ginsenosides with other drugs on BC will also be discussed. In addition, epigenetic changes, especially microRNAs (miRNAs) targeted by ginsenosides in the treatment of BC are clarified.

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Ginsenoside Rh2 inhibits breast cancer cell growth via<?A3B2 ACK?>ERβ-TNFα pathway

Cited by 13 publications

References 51 publications

An instant beverage rich in nutrients and secondary metabolites manufactured from stems and leaves of Panax notoginseng

An instant beverage rich in nutrients and secondary metabolites manufactured from stems and leaves of Panax notoginseng

Ginsenoside – a promising natural active ingredient with steroidal hormone activity

Anti-cancer effect and potential microRNAs targets of ginsenosides against breast cancer

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