Giresun İlinde FV, FXIII, ACE, ApoE Gen Varyantlarının Prevelansı ve Koroner Arter Hastalığı Profiline Etkilerinin Araştırılması

Akadam-Teker, Ayşegül Başak; Teker, Erhan; Yilmaz-Aydogan, Hülya; Aday, Aynur Dağlar

doi:10.38079/igusabder.590895

Cited by 1 publication

(1 citation statement)

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“…We conducted a comprehensive review to analyze APOE data within the healthy population of Turkey and compare the findings with our own results. From the total sample size of 1008, six articles and a thesis yielded findings closely aligned with our own data as seen in Table 7 [28][29][30][31][32][33]. During the course of the study, it was discovered that many of the same individuals had two or three polymorphisms at the same time.…”

Section: Discussionmentioning

confidence: 53%

Alzheimer Disease Associated Loci: APOE Single Nucleotide Polymorphisms in Marmara Region

Ismail,

Dundar,

Erguzeloglu

et al. 2024

Biomedicines

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Alzheimer’s disease (AD) is a major global health challenge, especially among individuals aged 65 or older. According to population health studies, Turkey has the highest AD prevalence in the Middle East and Europe. To accurately determine the frequencies of common and rare APOE single nucleotide polymorphisms (SNPs) in the Turkish population residing in the Marmara Region, we conducted a retrospective study analyzing APOE variants in 588 individuals referred to the Bursa Uludag University Genetic Diseases Evaluation Center. Molecular genotyping, clinical exome sequencing, bioinformatics analysis, and statistical evaluation were employed to identify APOE polymorphisms and assess their distribution. The study revealed the frequencies of APOE alleles as follows: ε4 at 9.94%, ε2 at 9.18%, and ε3 at 80.68%. The gender-based analysis in our study uncovered a tendency for females to exhibit a higher prevalence of mutant genotypes across various SNPs. The most prevalent haplotype observed was ε3/ε3, while rare APOE SNPs were also identified. These findings align with global observations, underscoring the significance of genetic diversity and gender-specific characteristics in comprehending health disparities and formulating preventive strategies.

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Section: Discussionmentioning

confidence: 53%