2010
DOI: 10.3109/14992027.2010.537377
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GJB2 and MTRNR1 contributions in children with hearing impairment from Northern Cameroon

Abstract: environmental factors turn out to be more relevant than genetic factor in the Maroua population.

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Cited by 16 publications
(14 citation statements)
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“…The KID syndrome is known to be due to mutations of the GJB2 gene [23]. Although the results of the GJB2 molecular screening of 70 deaf pupils in Maroua (Northern Cameroon) conducted by Trotta et al did not reveal the presence of pathogenic mutations in patients [12], we found two children of distinct ethnic groups presenting with the KID syndrome. Because GJB2 mutations could be ethnically specific, further molecular testing on the diverse Cameroonian samples is needed.…”
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confidence: 60%
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“…The KID syndrome is known to be due to mutations of the GJB2 gene [23]. Although the results of the GJB2 molecular screening of 70 deaf pupils in Maroua (Northern Cameroon) conducted by Trotta et al did not reveal the presence of pathogenic mutations in patients [12], we found two children of distinct ethnic groups presenting with the KID syndrome. Because GJB2 mutations could be ethnically specific, further molecular testing on the diverse Cameroonian samples is needed.…”
contrasting
confidence: 60%
“…Routine neonatal screening for deafness is not yet available in Cameroon and the impact of the vaccination programme on the occurrence of deafness has not been evaluated. Moreover, as a medical genetic service was inaugurated recently in Cameroon [11], molecular studies for deafness will become increasingly possible [12].…”
Section: Introductionmentioning
confidence: 99%
“…In those black patients for whom aminoglycoside induced ototoxicity was confirmed, researchers additional studies, suggesting a pathologic role in hearing loss (Trotta et al, 2011).…”
Section: Mtrnr1 (Mitochondrial 12s Ribosomal Rna)mentioning
confidence: 92%
“…Pure tone audiometry (PTA) was the most frequent tool used to diagnose HI. The study quality was high, moderate and low in ten [26][27][28][29][30][31][32][33][34][35], three [36][37][38] and four [39][40][41][42] studies, respectively.…”
Section: Characteristics Of Included Studiesmentioning
confidence: 99%