GKK1032C, a new alkaloid compound from the endophytic fungus Penicillium sp. CPCC 400817 with activity against methicillin-resistant S. aureus

Qi, Xin; Li, Xiaoqian; Zhao, Jin; He, Ning; Li, Yihong; Zou, Tao; Wang, Shanshan; Yu, Liyan; Xie, Yunying

doi:10.1038/s41429-019-0144-5

Cited by 34 publications

(22 citation statements)

References 8 publications

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“…In this context, fungal alkaloids are known for their potent antibacterial, anticancer, antiparasitic, and insecticidal activities [120]. In [121], a novel alkaloid compound, GKK1032C, is reported, which is produced by Penicillium sp. endophytically associated with the mangrove plant, exhibiting potent activity against methicillin-resistant S. aureus.…”

Section: Natural Products and Endophytic Fungimentioning

confidence: 99%

Plant-Associated Microorganisms as a Potent Bio-Factory of Active Molecules against Multiresistant Pathogens

Cruz¹,

Bogas²,

Sousa³

2021

Antimicrobial Resistance - A One Health Perspective

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Antibiotic-resistant pathogens are a public health threat that has rapidly spread over decades due to continuous and uncontrolled administration of antimicrobial medicines, becoming an ever-increasing worldwide concern. Since the past decade, no significant innovations have been made, so the search for new compounds that face multidrug-resistant pathogens is critically important. Plant-symbiont microorganisms are capable of producing a variety of bioactive natural products, making it possible to treat several infectious diseases. Biotechnological processes using microorganisms have been increasing in recent years since the discovery of Paclitaxel, an important antimitotic produced by the endophyte Taxomyces andreanae. It was isolated for the first time from the native tree of Pacific Taxus brevifolia. Several studies have demonstrated the isolation and characterization of promising and potent substances capable of inhibiting these pathogens. In addition, both rhizospheric and endophytic communities represent an unexplored reserve of unique chemical structures for drug development. This chapter focuses on the potential of plant-derived microorganisms as a source of bioactive substances and the perspectives for further studies and their application.

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Section: Natural Products and Endophytic Fungimentioning

confidence: 99%

Plant-Associated Microorganisms as a Potent Bio-Factory of Active Molecules against Multiresistant Pathogens

Cruz¹,

Bogas²,

Sousa³

2021

Antimicrobial Resistance - A One Health Perspective

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“…CPCC 400817 yielded one more new alkaloid (GKK1032C (1)) ( Figure 3D) and another four known alkaloids (pyrrospirones E (2), F (3) [7], GKK1032B (4) [8], and A2 (5)). Aside from GKK1032C (1), which was potent against MDR MRSA at a low concentration, other compounds had no inhibitory activity against Gram-negative bacteria such as ESBL Escherichia coli 46, and carbapenem-resistant bacteria [95]. An addition of NaBr instead of sea salt to the fermentation culture of this fungus led to the isolation of brominated azaphilones, new tricyclic polyketides, and two known penicilones ( Figure 3E).…”

Section: Marine Alga-associated Fungimentioning

confidence: 99%

mentioning

confidence: 99%

“…Structures of (A) desertomycin G (1)[55]; (B) isatin[69]; (C) TM1: 1, 3-dione-5,5dimethylcyclo-hexane (a), 2-enone-3hydroxy -5,5-dimethylcylohex (b), and that of TM2: 4H-1,3dioxin-4-one-2,3,6-trimethyl (c)[7]; (D) GKK1032C (1)[95]; (E) penicilones A and B (1, 2) (azaphilones), brominated azaphilones(5,6), penijanthinones A (7)[96], and (F) monomeric naphtho-γ-pyrones, peninaphones A-C (1-3)[97].…”

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confidence: 99%

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Antibiotics Development and the Potentials of Marine-Derived Compounds to Stem the Tide of Multidrug-Resistant Pathogenic Bacteria, Fungi, and Protozoa

et al. 2020

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As the search for new antibiotics continues, the resistance to known antimicrobial compounds continues to increase. Many researchers around the world, in response to antibiotics resistance, have continued to search for new antimicrobial compounds in different ecological niches such as the marine environment. Marine habitats are one of the known and promising sources for bioactive compounds with antimicrobial potentials against currently drug-resistant strains of pathogenic microorganisms. For more than a decade, numerous antimicrobial compounds have been discovered from marine environments, with many more antimicrobials still being discovered every year. So far, only very few compounds are in preclinical and clinical trials. Research in marine natural products has resulted in the isolation and identification of numerous diverse and novel chemical compounds with potency against even drug-resistant pathogens. Some of these compounds, which mainly came from marine bacteria and fungi, have been classified into alkaloids, lactones, phenols, quinones, tannins, terpenes, glycosides, halogenated, polyketides, xanthones, macrocycles, peptides, and fatty acids. All these are geared towards discovering and isolating unique compounds with therapeutic potential, especially against multidrug-resistant pathogenic microorganisms. In this review, we tried to summarize published articles from 2015 to 2019 on antimicrobial compounds isolated from marine sources, including some of their chemical structures and tests performed against drug-resistant pathogens.

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“…CPCC 400817. Among them, compounds 159 and 157 exhibited potent antibacterial activity against MRSA, with MIC values of 1.6 and 3.2 µg/mL [130]. The GKK1032 family possesses unique structural features, with 12-or 13-membered macrocyclic ether-containing 1,4-disubstituted phenyl and TA components, such as γ-lactam or succinimide scaffolds, and a rare tricarbocyclic system in polyketides [130].…”

Section: Pyrrocidine Tetramate Alkaloids (Ptas)mentioning

confidence: 99%

The Biological and Chemical Diversity of Tetramic Acid Compounds from Marine-Derived Microorganisms

Jiang

Chen

et al. 2020

Marine Drugs

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Tetramic acid (pyrrolidine-2,4-dione) compounds, isolated from a variety of marine and terrestrial organisms, have attracted considerable attention for their diverse, challenging structural complexity and promising bioactivities. In the past decade, marine-derived microorganisms have become great repositories of novel tetramic acids. Here, we discuss the biological activities of 277 tetramic acids of eight classifications (simple 3-acyl tetramic acids, 3-oligoenoyltetramic acids, 3-decalinoyltetramic acid, 3-spirotetramic acids, macrocyclic tetramic acids, N-acylated tetramic acids, α-cyclopiazonic acid-type tetramic acids, and other tetramic acids) from marine-derived microbes, including fungi, actinobacteria, bacteria, and cyanobacteria, as reported in 195 research studies up to 2019.

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GKK1032C, a new alkaloid compound from the endophytic fungus Penicillium sp. CPCC 400817 with activity against methicillin-resistant S. aureus

Cited by 34 publications

References 8 publications

Plant-Associated Microorganisms as a Potent Bio-Factory of Active Molecules against Multiresistant Pathogens

Plant-Associated Microorganisms as a Potent Bio-Factory of Active Molecules against Multiresistant Pathogens

Antibiotics Development and the Potentials of Marine-Derived Compounds to Stem the Tide of Multidrug-Resistant Pathogenic Bacteria, Fungi, and Protozoa

The Biological and Chemical Diversity of Tetramic Acid Compounds from Marine-Derived Microorganisms

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