Glargine insulin and high-protein-low-carbohydrate diet in cats with diabetes mellitus

Boari, Andrea; Aste, Giovanni; Rocconi, Francesca; Dalessandri, A.; Vita, Serena

doi:10.1007/s11259-008-9119-x

Cited by 16 publications

(13 citation statements)

References 6 publications

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“…Insulin glargine used over a 4-month period resulted in diabetic remission in 8 of 8 cats (100%), whereas only 3 of 8 cats (38%) treated with PZI and 2 of 8 cats (25%) treated with Lente insulin achieved remission (Marshall et al, 2009). Other studies using insulin glargine were not able to repeat the high treatment success: remission rates ranged between 17% and 47% (Boari et al, 2008;Hall et al, 2009;Hafner et al, 2011). In an Internet-based study using 55 diabetic cats from a German diabetes forum, a remission rate of 64% was achieved (Roomp and Rand, 2009).…”

Section: Long-acting Insulin Analoguesmentioning

confidence: 97%

“…The currently available studies, which have included information on remission, are difficult to compare, because they differ with regard to definition of remission, inclusion criteria of cats, blood glucose targets, and monitoring protocols, as well as type of insulin and type of diet. Published remission rates vary between 13% and 100% (Nelson et al, 1999;Bennett et al, 2006;Martin and Rand, 2007;Boari et al, 2008;Michiels et al, 2008;Marshall et al, 2009;Roomp and Rand, 2009;Hall et al, 2009;Zini et al, 2010;Hafner et al, 2011;Tschuor et al, 2011). It has been suggested that remission rates are higher in cats when treated with newer types of insulin (e.g., insulin analogues such as glargine or detemir) than with other/older types of insulin (e.g., Lente type) (Marshall et al, 2009;Roomp and Rand, 2009;.…”

Section: Remission Of Diabetes In Catsmentioning

confidence: 99%

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Feline Diabetes Mellitus

Reusch

2015

Canine and Feline Endocrinology

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Section: Long-acting Insulin Analoguesmentioning

confidence: 97%

Section: Remission Of Diabetes In Catsmentioning

confidence: 99%

Feline Diabetes Mellitus

Reusch

2015

Canine and Feline Endocrinology

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“…It is further supported by the two previous reports of 27/32 cats and 8/8 cats achieving remission when managed using a regimen similar to our near glycemic paradigm (Marshall et al 2009). When management strategies with a less aggressive target blood glucose ranges than the NEP were used, reported remission rates for cats with DM were lower, ranging from 17% to 50% (Frank et al 2001;Weaver et al 2006;Boari et al 2008;Sieber-Ruckstuhl et al 2008;Hall et al 2009;Zini et al 2010). Likewise, only 14% of the cats managed using TP in our study achieved remission.…”

Section: Discussionmentioning

confidence: 56%

In cats with newly diagnosed diabetes mellitus, use of a near-euglycemic management paradigm improves remission rate over a traditional paradigm

DeClue

2014

Veterinary Quarterly

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The object of this retrospective study was to compare the effect on remission rates of a near euglycemic paradigm (NEP) to a traditional paradigm (TP) of glycemic control in cats with newly diagnosed diabetes mellitus. Medical records of 54 cats with na€ ıve diabetes mellitus managed with low carbohydrate, high protein prescription diets, and twice daily subcutaneous glargine insulin injections were reviewed. Cats were assigned to an NEP or TP group based on frequency of evaluation of blood glucose concentration and the criteria used to assess glycemic control. The two groups were compared with regard to the incidence of clinical and biochemical hypoglycemia and remission rates. Multiple logistic regression was used to evaluate the association between remission and independent variables. Fourteen of 18 cats (78%) in the NEP group achieved remission, whereas five of the 36 (14%) of the TP group achieved remission (p < 0.001). For the NEP group, biochemical hypoglycemia was noted in 8/18 (44%) and clinical hypoglycemia was documented in 2/18 (11%) of the cats. In the TP group, biochemical hypoglycemia was noted in 12/36 (33%) cats and 5/36 (14%) had clinical hypoglycemia. In conclusion, management of newly diagnosed diabetic cats using an NEP of glycemic control results in higher remission rates without an increased incidence of observed clinical or biochemical hypoglycemia. Although an NEP appears to have benefit it should be evaluated further with regard to its overall and long term effects on health and quality of life as well as its overall cost effectiveness.

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“…High-protein, low-carbohydrate foods elicit lower glycemic responses compared with those containing high concentrations of carbohydrate, which can benefit dogs with insulin resistance or diabetes (57, 58). Furthermore, studies have shown that foods with a higher protein content (103 g/1000 kcal, or ∼31% for a 3000 kcal/kg diet), in addition to higher fiber content, decrease voluntary intake, increase the amount and rate of weight loss, and increase fat mass loss during weight loss in dogs (59, 60).…”

Section: Current Status Of Knowledgementioning

confidence: 99%

Nutritional Sustainability of Pet Foods

Swanson

Carter²,

Yount³

et al. 2013

Advances in Nutrition

105

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Sustainable practices meet the needs of the present without compromising the ability of future generations to meet their needs. Applying these concepts to food and feed production, nutritional sustainability is the ability of a food system to provide sufficient energy and essential nutrients required to maintain good health in a population without compromising the ability of future generations to meet their nutritional needs. Ecological, social, and economic aspects must be balanced to support the sustainability of the overall food system. The nutritional sustainability of a food system can be influenced by several factors, including the ingredient selection, nutrient composition, digestibility, and consumption rates of a diet. Carbon and water footprints vary greatly among plant- and animal-based ingredients, production strategy, and geographical location. Because the pet food industry is based largely on by-products and is tightly interlinked with livestock production and the human food system, however, it is quite unique with regard to sustainability. Often based on consumer demand rather than nutritional requirements, many commercial pet foods are formulated to provide nutrients in excess of current minimum recommendations, use ingredients that compete directly with the human food system, or are overconsumed by pets, resulting in food wastage and obesity. Pet food professionals have the opportunity to address these challenges and influence the sustainability of pet ownership through product design, manufacturing processes, public education, and policy change. A coordinated effort across the industry that includes ingredient buyers, formulators, and nutritionists may result in a more sustainable pet food system.

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Glargine insulin and high-protein-low-carbohydrate diet in cats with diabetes mellitus

Cited by 16 publications

References 6 publications

Feline Diabetes Mellitus

Feline Diabetes Mellitus

In cats with newly diagnosed diabetes mellitus, use of a near-euglycemic management paradigm improves remission rate over a traditional paradigm

Nutritional Sustainability of Pet Foods

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