Glass-ceramic coated Mg-Ca alloys for biomedical implant applications

Rau, Julietta V.; Antoniac, Iulian; Fosca, Marco; Bonis, Angela De; Blajan, Ana Iulia; Cotruț, Cosmin Mihai; Graziani, Valerio; Curcio, Mariangela; Cricenti, A.; Niculescu, Marius; Ortenzi, Marco Aldo; Teghil, R.

doi:10.1016/j.msec.2016.03.100

Cited by 76 publications

(54 citation statements)

References 38 publications

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“…Moreover, in vitro and in vivo studies highlighted the capability of RKKP glass‐ceramics to promote the formation of bonds not only in healthy but also in osteopenic bones (Fini et al, ). RKKP glass‐ceramics has been mainly studied in bulk (Krajewski et al, ; Ravaglioli et al, ) or as coating system on Zr, Ti (Aldini et al, ; Curcio et al, ; Curcio, De Stefanis, De Bonis, Teghil, & Rau, ; Ledda et al, ; Stanic et al, ), and Mg–Ca (Rau et al ) alloys.…”

Section: Introductionmentioning

confidence: 99%

Electrospun poly(d,l‐lactide)/gelatin/glass‐ceramics tricomponent nanofibrous scaffold for bone tissue engineering

Bochicchio

Barbaro

Bonis

et al. 2020

J Biomedical Materials Res

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Electrospun scaffolds are emerging as extracellular matrix (ECM)mimicking structures for tissue engineering thanks to their nanofibrous architecture. For the development of suitable electrospun scaffolds for bone tissue engineering, the addition of inorganic components has been implemented with the aim to confer important bioactivity like osteoinduction, osteointegration, and cell adhesion to the scaffolds. In this context, we propose a tricomponent electrospun scaffold composed of poly(d,l‐lactide), gelatin and RKKP glass‐ceramics. The bioactive RKKP glass‐ceramic system has attracted interest, due to the presence of ions such as La3+ and Ta5+, which turned out to be valuable as growth supporting agents for bones. In this work, RKKP glass‐ceramics were embedded inside the microfibers of electrospun scaffolds and the structural and biological properties were investigated. Our results showed that the glass‐ceramic microparticles were uniformly distributed in the fibrous structure of the scaffold. Furthermore, the glass‐ceramics promoted biomineralization of the scaffolds and improved cell viability and osteogenic differentiation. The mineralized layer formed on RKKP‐containing scaffolds after incubation in simulated body fluid medium has been shown to be hydroxyapatite by Raman spectroscopy and X‐ray diffraction. The results on differentiation studies of canine adipose‐derived mesenchymal stem cells grown on the electrospun scaffolds suggest that on varying the content of RKKP in the scaffold, it is possible to drive the differentiation toward chondrogenic or osteogenic commitment. The presence of ions, like La3+ and Ta5+, in the RKKP embedded polymeric composite scaffolds could play a role in supporting cell growth and promoting differentiation.

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Section: Introductionmentioning

confidence: 99%

Electrospun poly(d,l‐lactide)/gelatin/glass‐ceramics tricomponent nanofibrous scaffold for bone tissue engineering

Bochicchio

Barbaro

Bonis

et al. 2020

J Biomedical Materials Res

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“…Magnesium (Mg) is becoming the focus for the development of new materials for biomedical purposes. The interest on magnesium is promoted by its mechanical properties, the possibility of 2 being used for biodegradable devices and its biocompatibility [1][2][3][4][5][6][7]. However, the high degradation rate of Mg would prevent its usage because due to the fast, massive and detrimental release of hydrogen and hydroxide anions once it is in contact with physiological fluids or any aqueous media [8].…”

Section: Introductionmentioning

confidence: 99%

Bactericidal effect of magnesium ions over planktonic and sessile Staphylococcus epidermidis and Escherichia coli

Rodríguez-Sánchez

Pacha-Olivenza

González-Martı́n

2019

Materials Chemistry and Physics

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Magnesium and its alloys are in focus to produce implants due to their excellent mechanical properties, facility to decompose in the body, enhancement of new bone formation and antibacterial properties. However, there is still a lack of consensus about the origin of such antibacterial effect. Up to date, most antibacterial studies were performed over newly synthesized MgO particles, nanotubes or nanowires in the form of slurries, integrated within polymeric matrixes or as coatings of other bulk materials whereas the effect of pure Mg 2+ ions over bacteria viability, in the absence of secondary processes, has not been assessed yet. Hence, in this study, we have characterized the bactericidal effect of Mg 2+ ions over two different bacteria strains, Staphylococcus epidermidis (Gram-positive) and Escherichia coli (Gram-negative) controlling both pH and ion concentration. Also, we have considered the ion effect on dissimilar planktonic and sessile cells on surfaces with different hydrophobicity.

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“…In recent years, many rare earth elements (REs) have been added to increase mechanical properties, to prevent oxidation and increase corrosion resistance caused by the purifying effect of these elements in the alloy melt and the role of the phases they contain, which are attached to the grain boundaries, [8][9][10]. The cost of these elements is relatively high and stable, which weakens the potential for industrial applications of Mg alloys containing RE [22]. Therefore, new RE-Mg alloys with exceptional mechanical properties and corrosion resistance are required.…”

mentioning

confidence: 99%

Electrochemical Analysis of Some Biodegradable Mg-Ca-Mn Alloys

2020

Rev.Chim.

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The potential benefits of magnesium (Mg) over the other non-resorbable biomaterials, especially for orthopedic applications, are obvious. When fully realized, functional bioresorbable implants based on Mg alloys offer the mechanical advantages of a metal combined with the degradable and biological advantages of polymers and biomaterials. <1>In this article we obtained aMg-based prelate alloyed with Ca and Mn. It is known that Mn helps to refine the alloy’s microstructure, which adds to the elasticity of the material. Surface morphology was performed using the optical microscope and the electron microscope while the mechanical tests were performed using the tribometer. Also, the electrochemical tests were executed in the ringer solution. It has been mentioned that the electrochemical resistance is quite low. This study was conducted to determine the corrosion resistance of Mg-Ca-Mn alloys. It has been demonstrated that the addition of Mn refines the microstructure, increases the modulus of elasticity but does not have a qualitative resistance to corrosion.Also, the hardness of the material is quite low in comparison to other pre-alloys of Mg. Keywords: Surface morphology,mechanical tests, electrochemical tests

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Glass-ceramic coated Mg-Ca alloys for biomedical implant applications

Cited by 76 publications

References 38 publications

Electrospun poly(d,l‐lactide)/gelatin/glass‐ceramics tricomponent nanofibrous scaffold for bone tissue engineering

Electrospun poly(d,l‐lactide)/gelatin/glass‐ceramics tricomponent nanofibrous scaffold for bone tissue engineering

Bactericidal effect of magnesium ions over planktonic and sessile Staphylococcus epidermidis and Escherichia coli

Electrochemical Analysis of Some Biodegradable Mg-Ca-Mn Alloys

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