2020
DOI: 10.1186/s12935-020-01566-4
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Glioma exosomal microRNA-148a-3p promotes tumor angiogenesis through activating the EGFR/MAPK signaling pathway via inhibiting ERRFI1

Abstract: Background Glioma is the most frequent and lethal primary brain malignancy. Amounting evidence has highlighted the importance of exosomal microRNAs (miRNAs or miRs) in this malignancy. This study aimed to investigate the regulatory role of exosomal miR-148a-3p in glioma. Methods Bioinformatics analysis was firstly used to predict the target genes of miR-148a-3p. Exosomes were then extracted from normal human astrocytes and glioma cells. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) w… Show more

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Cited by 43 publications
(22 citation statements)
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“…In parallel, while the difference did not appear significant, we found interesting that miR-148a-3p and miR-335-5p were upregulated in TA-MSCs. MiR-148a-3p is a crucial regulator of GBM progression, by promoting tumor stem cell proliferation, migration, invasion and angiogenesis [ 67 , 68 , 69 , 70 , 71 , 72 ], while miR-335-5p has been shown to be upregulated in GBM [ 73 , 74 ].…”
Section: Discussionmentioning
confidence: 99%
“…In parallel, while the difference did not appear significant, we found interesting that miR-148a-3p and miR-335-5p were upregulated in TA-MSCs. MiR-148a-3p is a crucial regulator of GBM progression, by promoting tumor stem cell proliferation, migration, invasion and angiogenesis [ 67 , 68 , 69 , 70 , 71 , 72 ], while miR-335-5p has been shown to be upregulated in GBM [ 73 , 74 ].…”
Section: Discussionmentioning
confidence: 99%
“…Mechanically, miR-9 could target collagen type XVIII alpha 1 chain (COL18A1), thrombospondin 2 (THBS2), patched 1 (PTCH1), and egl-9 family hypoxia-inducible factor 3 (PHD3) to degrade these mRNA, contributing to initiating HIF-1a/VEGF signaling transduction (34). Besides, glioma-derived exosomal miR-148a-3p reinforced angiogenesis through activating the EGFR/MAPK signaling pathway with the ERBB receptor feedback inhibitor 1 (ERRFI1) (35).…”
Section: Exosomal Mirnas and Angiogenesis In Gliomamentioning
confidence: 99%
“…The EGFR/mitogen activated protein kinase (MAPK) pathway is known to contribute to glioma progression (Qu et al, 2012). Recently, Wang et al (2020) evaluated the regulatory role of exosomal miR-148a-3p in glioma. In this research, the exosomes were isolated from glioma cells and healthy human astrocytes, and the expression level of exosomal miR-148a-3p was measured by RT-qPCR.…”
Section: Exosomal Non-coding Rnas and Angiogenesismentioning
confidence: 99%
“…Furthermore, inhibition of ERRFI1 activated the EGFR/MAPK pathway via miR-148a-3p. This mechanism was suggested to be responsible for the promotion of angiogenesis and tumorigenesis by exosomal miR-148a-3p (Wang et al, 2020).…”
Section: Exosomal Non-coding Rnas and Angiogenesismentioning
confidence: 99%