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Grodzinski, Piotr; Liu, R.H.; Chen, B.; Blackwell, J.; Liu, Y.; Rhine, David; Smekal, Thomas; Ganser, Dale; Romero, Carlos De la Rosa; Huang, Yu; Chan, Tony F.; Kroutchinina, Natalia

doi:10.1023/a:1012400629650

Cited by 37 publications

(10 citation statements)

References 13 publications

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“…Integration allows for rapid clinical diagnosis tests, easy usage without complex fluid handling, fewer costly reagents, smaller sample volumes, and shorter assay turnaround systems. In addition, such systems eliminate the often slow, complex and costly preparation techniques of conventional clinical laboratories, such as centrifugal techniques and membrane filtration [8,13,37,38,[40][41][42][43][44][45].…”

Section: Integrated Microfluidic Devicesmentioning

confidence: 99%

Integration of functionality into polymer-based microfluidic devices produced by high-volume micro-moulding techniques

Attia

Alcock

2009

Int J Adv Manuf Technol

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Microfluidic devices with integrated functional elements have gained increasing attention in the recent years. Many prototypes covering a wide range of applications have been fabricated and tested, especially in the fields of chemical and biomedical sciences. Nevertheless, integrated microfluidic devices are still far from being widely used as cost-efficient commercial products, often because they are produced by fabrication methods that are not suitable for mass production. Several methods have been recently introduced for cost-efficient high-volume production of micro-featured plastic parts, such as micro-injection moulding and hot-embossing. These methods have been widely used for fabricating simple disposable microfluidic chips on a commercial scale, but have not yet been similarly applied for producing integrated microfluidic devices. This review paper aims at presenting the state of the art in integrated microfluidic devices produced by cost-efficient high-volume replication processes. It takes micro-injection moulding and hot-embossing as its two process examples. Several types of elements are classified according to their functions, defined relative to their physical inputs and outputs. Their level of integration is reviewed. In addition, elements are discussed from a manufacturing viewpoint, in terms of being readily produced by replication techniques or by back-end processes. Current and future challenges in integration are presented and discussed.

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Section: Integrated Microfluidic Devicesmentioning

confidence: 99%

Integration of functionality into polymer-based microfluidic devices produced by high-volume micro-moulding techniques

Attia

Alcock

2009

Int J Adv Manuf Technol

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“…Apart from the commonly used glass and silica, polymer-based materials, such as polydimethylsiloxene (PDMS), polymethyl-methacrylate (PMMA), polyolefin, Mylar and polycarbonate (Grodzinski et al 2001;Kameoka et al 2001;Kricka 2001;Chovan and Guttman 2002;Craighead 2006;Psaltis et al 2006;Whitesides 2006) have been introduced as microfluidic materials. PDMS dissolves in or is swelled by many organic solvent (Lee et al 2003), and is permeable to many small and hydrophobic molecules .…”

Section: Introductionmentioning

confidence: 99%

“…Thin laminate sheets, such as Mylar and PMMA, may solve the problems (Weigl et al 2001;Whitesides 2006;. Microfluidic channels based on laminate can be fabricated easily through molding, embossing and casting process (Grodzinski et al 2001;Weigl et al 2001;Klank et al 2002;Weigl et al 2003;Craighead 2006;Whitesides 2006;. In this paper, the microchannels on Mylar were fabricated in less than an hour using a direct-write CO 2 laser system and the Mylar microchannels were held together with PMMA sheets using pressure-sensitive adhesive.…”

Section: Introductionmentioning

confidence: 99%

Integration of optical fiber light guide, fluorescence detection system, and multichannel disposable microfluidic chip

Irawan

Tjin

Fang

et al. 2007

Biomed Microdevices

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A combination of fluorescence detection and microfluidic technology provides promising applications in life sciences. A prototype of an integrated fluorescence detection system and optical fiber light guide on a laminate-based multichannel microfluidic chip has been developed and tested. A blue LED, plastic optical fiber, photodiode, Mylar and PMMA, and fluorescein and BSA-FITC were used as an excitation source, light coupler and guide, detector, microfluidic substrate and sample, respectively. The results show that the system is capable of detecting weak fluorescence emission from a fluorescein solution at concentration down to 0.01 ng/ml, and gives linear response. The results were also reproducible, and no cross-talk between adjacent channels was observed. The test using BSA as a model analyte demonstrates its feasibility for on-chip immunosensor applications. The performance and applications can be developed further. This prototype can be used as a platform to develop a simple and compact bio-fluorescence detection system integrated with an inexpensive and disposable multichannel microfluidic chip for biomedical devices.

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“…However, manufacturing microchips using conventional substrate materials such as glass, plastic or silicon is expensive since the fabrication process requires multiple photolithographic and etching steps (Hong et al 2001;Grodzinski et al 2001;Yamahata et al 2005). In addition, the manufacturing process lacks the flexibility to support rapid design changes during the microchip development stage.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of UV epoxy resin masters for the replication of PDMS-based microchips

Pan

Yang

2007

Biomed Microdevices

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This paper presents two methods for the fabrication of UV epoxy resin masters for the replication of PDMS-based microfluidic chips. In the first method, the epoxy resin master is fabricated from a negative glass template manufactured using conventional lithography and wet etching techniques. However, in the second method, the master is produced simply by exposing a layer of UV epoxy resin coated on a glass substrate. Although the first method enables the replication of multiple PDMS structures from a single master, the latter method avoids the requirement for a wet chemical etching process and enables the epoxy master to be produced in 40 min or less. The experimental results show that the epoxy resin masters enable the mass production of PDMS replicas with highly precise geometrical tolerances. A series of electrokinetic focusing experiments are performed using PDMS microchips replicated from the current epoxy resin masters. The experimental results obtained for the width of the electrokinetically-focused sample stream under different focusing ratios are found to be in good agreement with the theoretical predictions. The sample handling characteristics of the microfluidic chips are also investigated. It is shown that the sample flow can be electrokinetically pre-focused into a narrow stream and then guided to the desired outlet port by applying a simple voltage control model. Finally, it is demonstrated that through an appropriate alignment of the sample flow and the conductivity gradient, the electrokinetic instability phenomenon can be induced at a relatively low electrical field strength of 0.35 kV/cm.

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Untitled

Cited by 37 publications

References 13 publications

Integration of functionality into polymer-based microfluidic devices produced by high-volume micro-moulding techniques

Integration of functionality into polymer-based microfluidic devices produced by high-volume micro-moulding techniques

Integration of optical fiber light guide, fluorescence detection system, and multichannel disposable microfluidic chip

Fabrication of UV epoxy resin masters for the replication of PDMS-based microchips

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