This chapter addresses the global impacts of heterogenous chemicals and toxic substances on human health and the environment. Chemicals and hazardous substances are ubiquitous in every nook and cranny of society across the globe. The challenges facing the scientific community in documenting the number and variety of chemicals, and hazardous products that are manufactured, available on the market, and in use as well as the disease burden associated with them are discussed. The chapter addresses the chemicals, hazardous substances of global public health concern, including air pollution, inorganic substances especially heavy metals, and synthetic organic compounds such as the Persistent Organic Pollutants (POPs) and pesticides. Gaseous elements, acids and bases are also covered. Major sources of releases into the environment and routes of exposure and the consequences for exposed population's health and well-being are addressed. The estimated Global Burden of Disease (GBD), Disability Adjusted Life Years (DALYs), and economic loss associated with selected chemical