Global histone modification analysis reveals hypoacetylated H3 and H4 histones in B Cells from systemic lupus erythematosus patients

Gautam, Preeti; Sharma, Aman; Bhatnagar, Archana

doi:10.1016/j.imlet.2021.09.007

Cited by 13 publications

(8 citation statements)

References 20 publications

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“…Predominantly hypermethylated CpG islands were observed in disease-associated B cells, and the most important upstream regulators included TNF and EP300 [20]. Additionally, a global search of histone modification revealed that H3 and H4 are hypoacetylated in B cells from SLE patients [45]. Epigenetic regulation of abnormal X-linked gene expression also impacted the female disease susceptibility.…”

Section: B-cell Epigenetic Alterations In Lupusmentioning

confidence: 99%

Epigenetic Alterations in Immune Cells of Systemic Lupus Erythematosus and Therapeutic Implications

Adams

Shao

2022

Cells

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Systemic lupus erythematosus (SLE) is an autoimmune disorder that is characterized by autoantibody production and dysregulated immune cell activation. Although the exact etiology of SLE remains unknown, genetic, hormonal, and complex environmental factors are known to be critical for pathologic immune activation. In addition to the inherited genetic predisposition, epigenetic processes that do not change the genomic code, such as DNA methylation, histone modification, and noncoding RNAs are increasingly appreciated to play important roles in lupus pathogenesis. We herein focus on the up-to-date findings of lupus-associated epigenetic alterations and their pathophysiology in lupus development. We also summarize the therapeutic potential of the new findings. It is likely that advances in the epigenetic study will help to predict individual disease outcomes, promise diagnostic accuracy, and design new target-directed immunotherapies.

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Section: B-cell Epigenetic Alterations In Lupusmentioning

confidence: 99%

Epigenetic Alterations in Immune Cells of Systemic Lupus Erythematosus and Therapeutic Implications

Adams

Shao

2022

Cells

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“…An altered state of histone modifications has been suggested in SLE. Gautam et al showed that SLE patients presented H3 and H4 hyperacetylation with a decrease in DNMT1 expression compared to healthy controls; elevated histone H3 acetylation has also been correlated with the clinical disease activity in SLE [ 22 , 29 ] ( Table 1 ) ( Figure 1 ). In addition, Fang et al described that SLE patients had higher methylation and thus lower expression in the histone deacetylases 6 ( HDAC6 ) promoter than healthy controls; decreased HDAC6 levels could result in increased histone acetylation and high immune-related gene expression; therefore, the authors suggested that may be related to SLE susceptibility [ 23 ] ( Table 1 ).…”

Section: Epigenetic Mechanisms Related To Sle Pathophysiologymentioning

confidence: 99%

Methyl Donor Micronutrients: A Potential Dietary Epigenetic Target in Systemic Lupus Erythematosus Patients

Pesqueda-Cendejas

Campos-López

Mora-García

et al. 2023

IJMS

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Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by an aberrant immune response and persistent inflammation. Its pathogenesis remains unknown; however, a complex interaction between environmental, genetic, and epigenetic factors has been suggested to cause disease onset. Several studies have demonstrated that epigenetic alterations, such as DNA hypomethylation, miRNA overexpression, and altered histone acetylation, may contribute to SLE onset and the disease’s clinical manifestations. Epigenetic changes, especially methylation patterns, are modifiable and susceptible to environmental factors such as diet. It is well known that methyl donor nutrients, such as folate, methionine, choline, and some B vitamins, play a relevant role in DNA methylation by participating as methyl donors or coenzymes in one-carbon metabolism. Based on this knowledge, this critical literature review aimed to integrate the evidence in animal models and humans regarding the role of nutrients in epigenetic homeostasis and their impact on immune system regulation to suggest a potential epigenetic diet that could serve as adjuvant therapy in SLE.

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“…In SLE, which can be considered a model disease for B celldependent inflammatory autoimmune disorders, histone H3 and H4 acetylation is reduced overall compared with healthy controls (89). Increasing histone acetylation via the pharmacological inhibition of class IIb HDAC6 decreased PC differentiation, Ab formation, and immune-complex mediated glomerulonephritis in murine SLE models (90, 91).…”

Section: Implications For Inflammatory (Autoimmune) Conditionsmentioning

confidence: 99%

Influence of nutrients and metabolites on the differentiation of plasma cells and implications for autoimmunity

et al. 2022

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The modulation of inflammatory (auto)immune reactions by nutrients and gut bacterial metabolites is of great interest for potential preventive and therapeutic strategies. B cell-derived plasma cells are major players in inflammatory (auto)immune responses and can exhibit pro- or anti-inflammatory effects through (auto)antibody-dependent and -independent functions. Emerging evidence indicates a key role of nutrients and microbial metabolites in regulating the differentiation of plasma cells as well as their differentiation to pro- or anti-inflammatory phenotypes. These effects might be mediated indirectly by influencing other immune cells or directly through B cell-intrinsic mechanisms. Here, we provide an overview of nutrients and metabolites that influence B cell-intrinsic signaling pathways regulating B cell activation, plasma cell differentiation, and effector functions. Furthermore, we outline important inflammatory plasma cell phenotypes whose differentiation could be targeted by nutrients and microbial metabolites. Finally, we discuss possible implications for inflammatory (auto)immune conditions.

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Global histone modification analysis reveals hypoacetylated H3 and H4 histones in B Cells from systemic lupus erythematosus patients

Cited by 13 publications

References 20 publications

Epigenetic Alterations in Immune Cells of Systemic Lupus Erythematosus and Therapeutic Implications

Epigenetic Alterations in Immune Cells of Systemic Lupus Erythematosus and Therapeutic Implications

Methyl Donor Micronutrients: A Potential Dietary Epigenetic Target in Systemic Lupus Erythematosus Patients

Influence of nutrients and metabolites on the differentiation of plasma cells and implications for autoimmunity

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